ID F1RGA3_PIG Unreviewed; 295 AA.
AC F1RGA3;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 4.
DT 27-MAR-2024, entry version 83.
DE RecName: Full=Syntaxin-1A {ECO:0000256|ARBA:ARBA00040530};
GN Name=STX1A {ECO:0000313|Ensembl:ENSSSCP00000008300.4,
GN ECO:0000313|VGNC:VGNC:93589};
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00000008300.4, ECO:0000313|Proteomes:UP000008227};
RN [1] {ECO:0000313|Ensembl:ENSSSCP00000008300.4, ECO:0000313|Proteomes:UP000008227}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000008300.4,
RC ECO:0000313|Proteomes:UP000008227};
RG Porcine genome sequencing project;
RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSSCP00000008300.4}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004236}.
CC Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane
CC {ECO:0000256|ARBA:ARBA00004143}; Single-pass type IV membrane protein
CC {ECO:0000256|ARBA:ARBA00004143}. Membrane
CC {ECO:0000256|ARBA:ARBA00004211}; Single-pass type IV membrane protein
CC {ECO:0000256|ARBA:ARBA00004211}.
CC -!- SIMILARITY: Belongs to the syntaxin family.
CC {ECO:0000256|ARBA:ARBA00009063, ECO:0000256|RuleBase:RU003858}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; F1RGA3; -.
DR SMR; F1RGA3; -.
DR STRING; 9823.ENSSSCP00000008300; -.
DR PeptideAtlas; F1RGA3; -.
DR Ensembl; ENSSSCT00000008519.5; ENSSSCP00000008300.4; ENSSSCG00000007772.5.
DR VGNC; VGNC:93589; STX1A.
DR GeneTree; ENSGT01030000234627; -.
DR HOGENOM; CLU_042423_2_2_1; -.
DR InParanoid; F1RGA3; -.
DR TreeFam; TF313763; -.
DR Reactome; R-SSC-181429; Serotonin Neurotransmitter Release Cycle.
DR Reactome; R-SSC-181430; Norepinephrine Neurotransmitter Release Cycle.
DR Reactome; R-SSC-210500; Glutamate Neurotransmitter Release Cycle.
DR Reactome; R-SSC-212676; Dopamine Neurotransmitter Release Cycle.
DR Reactome; R-SSC-264642; Acetylcholine Neurotransmitter Release Cycle.
DR Reactome; R-SSC-449836; Other interleukin signaling.
DR Reactome; R-SSC-5682910; LGI-ADAM interactions.
DR Reactome; R-SSC-888590; GABA synthesis, release, reuptake and degradation.
DR Reactome; R-SSC-9609523; Insertion of tail-anchored proteins into the endoplasmic reticulum membrane.
DR Proteomes; UP000008227; Chromosome 3.
DR Bgee; ENSSSCG00000007772; Expressed in frontal cortex and 34 other cell types or tissues.
DR ExpressionAtlas; F1RGA3; baseline and differential.
DR GO; GO:0030424; C:axon; IEA:Ensembl.
DR GO; GO:0012505; C:endomembrane system; IBA:GO_Central.
DR GO; GO:0031965; C:nuclear membrane; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0048787; C:presynaptic active zone membrane; IBA:GO_Central.
DR GO; GO:0031201; C:SNARE complex; IBA:GO_Central.
DR GO; GO:0008021; C:synaptic vesicle; IBA:GO_Central.
DR GO; GO:0030672; C:synaptic vesicle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0070044; C:synaptobrevin 2-SNAP-25-syntaxin-1a complex; IEA:Ensembl.
DR GO; GO:0019855; F:calcium channel inhibitor activity; IEA:Ensembl.
DR GO; GO:0019869; F:chloride channel inhibitor activity; IEA:Ensembl.
DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR GO; GO:0019900; F:kinase binding; IEA:Ensembl.
DR GO; GO:0005484; F:SNAP receptor activity; IBA:GO_Central.
DR GO; GO:0000149; F:SNARE binding; IBA:GO_Central.
DR GO; GO:0017156; P:calcium-ion regulated exocytosis; IEA:Ensembl.
DR GO; GO:0006887; P:exocytosis; IBA:GO_Central.
DR GO; GO:0030073; P:insulin secretion; IEA:Ensembl.
DR GO; GO:0006886; P:intracellular protein transport; IBA:GO_Central.
DR GO; GO:2000463; P:positive regulation of excitatory postsynaptic potential; IEA:Ensembl.
DR GO; GO:0001956; P:positive regulation of neurotransmitter secretion; IEA:Ensembl.
DR GO; GO:0016925; P:protein sumoylation; IEA:Ensembl.
DR GO; GO:0010807; P:regulation of synaptic vesicle priming; IEA:Ensembl.
DR GO; GO:0048488; P:synaptic vesicle endocytosis; IEA:Ensembl.
DR GO; GO:0031629; P:synaptic vesicle fusion to presynaptic active zone membrane; IBA:GO_Central.
DR GO; GO:0048278; P:vesicle docking; IBA:GO_Central.
DR CDD; cd15880; SNARE_syntaxin1; 1.
DR CDD; cd00179; SynN; 1.
DR Gene3D; 1.20.5.110; -; 1.
DR Gene3D; 1.20.58.70; -; 1.
DR InterPro; IPR010989; SNARE.
DR InterPro; IPR045242; Syntaxin.
DR InterPro; IPR006012; Syntaxin/epimorphin_CS.
DR InterPro; IPR006011; Syntaxin_N.
DR InterPro; IPR000727; T_SNARE_dom.
DR PANTHER; PTHR19957; SYNTAXIN; 1.
DR PANTHER; PTHR19957:SF84; SYNTAXIN-1A; 1.
DR Pfam; PF05739; SNARE; 1.
DR Pfam; PF00804; Syntaxin; 2.
DR SMART; SM00503; SynN; 1.
DR SMART; SM00397; t_SNARE; 1.
DR SUPFAM; SSF47661; t-snare proteins; 1.
DR PROSITE; PS00914; SYNTAXIN; 1.
DR PROSITE; PS50192; T_SNARE; 1.
PE 1: Evidence at protein level;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329};
KW Exocytosis {ECO:0000256|ARBA:ARBA00022483};
KW Isopeptide bond {ECO:0000256|ARBA:ARBA00022499};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Proteomics identification {ECO:0007829|PeptideAtlas:F1RGA3};
KW Reference proteome {ECO:0000313|Proteomes:UP000008227};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT TRANSMEM 273..294
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 199..261
FT /note="T-SNARE coiled-coil homology"
FT /evidence="ECO:0000259|PROSITE:PS50192"
FT REGION 1..37
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 86..124
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 295 AA; 33405 MW; FF286294766F98AD CRC64;
MLGSPGSQAQ WDPVVLPPSA HGCTPSMQAK DSDDDDDVTV TVDRDRFMDE FFEQVEEIRG
FIDKIAENVE EVKRKHSAIL ASPNPDEKTK EELEELMSDI KKTANKVRSK LKSIEQSIEQ
EEGLNRSSAD LRIRKTQHST LSRKFSDYRE RCKGRIQRQL EISKMRGLPL PLASCCPGPS
PHPTPFCIIM DSSVSKQALS EIETRHSEII KLENSIRELH DMFMDMAMLV ESQGEMIDRI
EYNVEHSVDY VERAVSDTKK AVKYQSKARR KKIMIIICCV VLGIVIASTF GGIFG
//
