ID F1RGK1_PIG Unreviewed; 529 AA.
AC F1RGK1;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 3.
DT 27-MAR-2024, entry version 59.
DE SubName: Full=Transmembrane protein 145 {ECO:0000313|Ensembl:ENSSSCP00000003273.3};
GN Name=TMEM145 {ECO:0000313|Ensembl:ENSSSCP00000003273.3,
GN ECO:0000313|VGNC:VGNC:94092};
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00000003273.3, ECO:0000313|Proteomes:UP000008227};
RN [1] {ECO:0000313|Ensembl:ENSSSCP00000003273.3, ECO:0000313|Proteomes:UP000008227}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000003273.3,
RC ECO:0000313|Proteomes:UP000008227};
RG Porcine genome sequencing project;
RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSSCP00000003273.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR AlphaFoldDB; F1RGK1; -.
DR Ensembl; ENSSSCT00000003356.3; ENSSSCP00000003273.3; ENSSSCG00000003022.5.
DR VGNC; VGNC:94092; TMEM145.
DR GeneTree; ENSGT00940000153981; -.
DR HOGENOM; CLU_021549_3_0_1; -.
DR Proteomes; UP000008227; Chromosome 6.
DR Bgee; ENSSSCG00000003022; Expressed in prefrontal cortex and 29 other cell types or tissues.
DR ExpressionAtlas; F1RGK1; baseline and differential.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IEA:InterPro.
DR GO; GO:0019236; P:response to pheromone; IEA:InterPro.
DR InterPro; IPR047831; GPR180/TMEM145.
DR InterPro; IPR019336; GPR180/TMEM145_TM.
DR PANTHER; PTHR23252; INTIMAL THICKNESS RECEPTOR-RELATED; 1.
DR PANTHER; PTHR23252:SF24; TRANSMEMBRANE PROTEIN 145; 1.
DR Pfam; PF10192; GpcrRhopsn4; 1.
PE 4: Predicted;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000008227};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..29
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 30..529
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5012113093"
FT TRANSMEM 189..209
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 221..243
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 255..274
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 294..311
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 158..320
FT /note="GPR180/TMEM145 transmembrane"
FT /evidence="ECO:0000259|Pfam:PF10192"
FT REGION 426..529
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 441..476
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 529 AA; 58186 MW; 6FD1A7273A0F0C84 CRC64;
MEPPRAPALR RLLPSLLLLL LPLPPRARAK YVRGNLSSKE DWVFLTRFCF LSDYGRLDFR
FRYPEAKCCQ NILLYFDDPS QWPAVYKAGD KDCLAKESVI RPENNQVINL TTQYAWSGCQ
VVSEEGTRYL SCSSGRSFRS VRERWWYIAL SKCGGDGLQL EYEMVLTNGK SFWTRHFSAD
EFGILETDVT FLLIFILIFF LSCYFGYLLK GRQLLHTTYK MFMAAAGVEV LSLLFFCIYW
GQYATDGIGN ESLKIVAKLL FSSSFLIFLL MLILLGKGFT VTRGRISHSG SVKLSVYMTL
YTLTHVVLLI YEAEVLCSSS HGPDCQLWDP KVGPGEDRQW HSAGDPFVCP WRVPDHDTPF
GGQQELPVPR AHVADRLSRS PGPGREPISR QGLPAARLWE RDVHQRLGAQ LHGALLHPPA
RLLCKPRAPG ARGAAGAAPG VPDPAPGPST TLHTPAPEPT PCFSHPPRPN AAPRPFPGAC
AHPAGLGPGA VAHAPSDAPR GAPAAGLPRF SLPSPAAAGV RPPHPDAAP
//
