ID F1RHJ1_PIG Unreviewed; 216 AA.
AC F1RHJ1; A0A4X1VZF5;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 03-MAY-2011, sequence version 1.
DT 27-MAR-2024, entry version 85.
DE RecName: Full=Large ribosomal subunit protein uL24m {ECO:0000256|ARBA:ARBA00035283};
DE AltName: Full=39S ribosomal protein L24, mitochondrial {ECO:0000256|ARBA:ARBA00035357};
GN Name=MRPL24 {ECO:0000313|Ensembl:ENSSSCP00000006894.2,
GN ECO:0000313|VGNC:VGNC:90357};
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00000006894.2, ECO:0000313|Proteomes:UP000008227};
RN [1] {ECO:0000313|Ensembl:ENSSSCP00000006894.2, ECO:0000313|Proteomes:UP000008227}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000006894.2,
RC ECO:0000313|Proteomes:UP000008227};
RG Porcine genome sequencing project;
RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0007829|PDB:4CE4}
RP STRUCTURE BY ELECTRON MICROSCOPY (4.90 ANGSTROMS).
RX PubMed=24362565; DOI=10.1038/nature12890;
RA Greber B.J., Boehringer D., Leitner A., Bieri P., Voigts-Hoffmann F.,
RA Erzberger J.P., Leibundgut M., Aebersold R., Ban N.;
RT "Architecture of the large subunit of the mammalian mitochondrial
RT ribosome.";
RL Nature 505:515-519(2014).
RN [3] {ECO:0007829|PDB:4V19}
RP STRUCTURE BY ELECTRON MICROSCOPY (3.40 ANGSTROMS).
RX PubMed=25271403; DOI=10.1038/nature13895;
RA Greber B.J., Boehringer D., Leibundgut M., Bieri P., Leitner A.,
RA Schmitz N., Aebersold R., Ban N.;
RT "The complete structure of the large subunit of the mammalian mitochondrial
RT ribosome.";
RL Nature 515:283-286(2014).
RN [4] {ECO:0007829|PDB:5AJ4}
RP STRUCTURE BY ELECTRON MICROSCOPY (3.80 ANGSTROMS).
RX PubMed=25837512; DOI=10.1126/science.aaa3872;
RA Greber B.J., Bieri P., Leibundgut M., Leitner A., Aebersold R.,
RA Boehringer D., Ban N.;
RT "Ribosome. The complete structure of the 55S mammalian mitochondrial
RT ribosome.";
RL Science 348:303-308(2015).
RN [5] {ECO:0007829|PDB:6GAW, ECO:0007829|PDB:6GB2}
RP STRUCTURE BY ELECTRON MICROSCOPY (3.20 ANGSTROMS).
RX PubMed=30089917; DOI=10.1038/s41586-018-0373-y;
RA Kummer E., Leibundgut M., Rackham O., Lee R.G., Boehringer D.,
RA Filipovska A., Ban N.;
RT "Unique features of mammalian mitochondrial translation initiation revealed
RT by cryo-EM.";
RL Nature 560:263-267(2018).
RN [6] {ECO:0000313|EMBL:HDB48432.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=30723633; DOI=.7717/peerj.6374;
RA Gilbert D.G.;
RT "Genes of the pig, Sus scrofa, reconstructed with EvidentialGene.";
RL PeerJ 7:E6374-E6374(2019).
RN [7] {ECO:0007829|PDB:6YDP, ECO:0007829|PDB:6YDW}
RP STRUCTURE BY ELECTRON MICROSCOPY (3.00 ANGSTROMS).
RX PubMed=32602580; DOI=10.15252/embj.2020104820;
RA Kummer E., Ban N.;
RT "Structural insights into mammalian mitochondrial translation elongation
RT catalyzed by mtEFG1.";
RL EMBO J. 39:e104820-e104820(2020).
RN [8] {ECO:0007829|PDB:7NQH, ECO:0007829|PDB:7NQL}
RP STRUCTURE BY ELECTRON MICROSCOPY (3.20 ANGSTROMS).
RX PubMed=33878294; DOI=10.1016/j.molcel.2021.03.042;
RA Kummer E., Schubert K.N., Schoenhut T., Scaiola A., Ban N.;
RT "Structural basis of translation termination, rescue, and recycling in
RT mammalian mitochondria.";
RL Mol. Cell 81:2566-2582(2021).
RN [9] {ECO:0007829|PDB:8OIN, ECO:0007829|PDB:8OIQ}
RP STRUCTURE BY ELECTRON MICROSCOPY (3.50 ANGSTROMS).
RX PubMed=37141370; DOI=10.1126/science.adf9890;
RA Saurer M., Leibundgut M., Nadimpalli H.P., Scaiola A., Schonhut T.,
RA Lee R.G., Siira S.J., Rackham O., Dreos R., Lenarcic T., Kummer E.,
RA Gatfield D., Filipovska A., Ban N.;
RT "Molecular basis of translation termination at noncanonical stop codons in
RT human mitochondria.";
RL Science 380:531-536(2023).
RN [10] {ECO:0000313|Ensembl:ENSSSCP00000006894.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the universal ribosomal protein uL24 family.
CC {ECO:0000256|ARBA:ARBA00010618, ECO:0000256|RuleBase:RU003477}.
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DR EMBL; DQIR01192955; HDB48432.1; -; Transcribed_RNA.
DR RefSeq; NP_001231376.1; NM_001244447.1.
DR RefSeq; NP_001231377.1; NM_001244448.1.
DR RefSeq; XP_005663313.1; XM_005663256.2.
DR RefSeq; XP_005663314.1; XM_005663257.2.
DR PDB; 4CE4; EM; 4.90 A; Y=1-216.
DR PDB; 4V19; EM; 3.40 A; Y=1-216.
DR PDB; 5AJ4; EM; 3.80 A; BY=1-216.
DR PDB; 6GAW; EM; 3.20 A; BY=1-216.
DR PDB; 6GB2; EM; 3.20 A; BY=1-216.
DR PDB; 6YDP; EM; 3.00 A; BY=1-216.
DR PDB; 6YDW; EM; 4.20 A; BY=1-216.
DR PDB; 7NQH; EM; 3.50 A; BY=1-216.
DR PDB; 7NQL; EM; 3.40 A; BY=1-216.
DR PDB; 7NSH; EM; 3.20 A; BY=1-216.
DR PDB; 7NSI; EM; 4.60 A; BY=1-216.
DR PDB; 7NSJ; EM; 3.90 A; BY=1-216.
DR PDB; 8OIN; EM; 3.60 A; BC=1-216.
DR PDB; 8OIQ; EM; 3.50 A; BC=1-216.
DR PDBsum; 4CE4; -.
DR PDBsum; 4V19; -.
DR PDBsum; 5AJ4; -.
DR PDBsum; 6GAW; -.
DR PDBsum; 6GB2; -.
DR EMDB; EMD-12568; -.
DR EMDB; EMD-16894; -.
DR EMDB; EMD-16896; -.
DR PaxDb; 9823-ENSSSCP00000006894; -.
DR Ensembl; ENSSSCT00000007086.5; ENSSSCP00000006894.2; ENSSSCG00000006469.5.
DR Ensembl; ENSSSCT00005011745.1; ENSSSCP00005006836.1; ENSSSCG00005007833.1.
DR GeneID; 100156363; -.
DR KEGG; ssc:100156363; -.
DR CTD; 79590; -.
DR VGNC; VGNC:90357; MRPL24.
DR eggNOG; KOG1708; Eukaryota.
DR GeneTree; ENSGT00390000014542; -.
DR HOGENOM; CLU_093315_0_1_1; -.
DR OMA; DFEWRFT; -.
DR OrthoDB; 36159at2759; -.
DR TreeFam; TF105984; -.
DR Proteomes; UP000008227; Chromosome 4.
DR Bgee; ENSSSCG00000006469; Expressed in semimembranosus muscle and 45 other cell types or tissues.
DR Genevisible; F1RHJ1; SS.
DR GO; GO:0005762; C:mitochondrial large ribosomal subunit; IEA:Ensembl.
DR GO; GO:0031090; C:organelle membrane; IEA:UniProt.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003735; F:structural constituent of ribosome; IEA:InterPro.
DR GO; GO:0006412; P:translation; IEA:InterPro.
DR CDD; cd06089; KOW_RPL26; 1.
DR Gene3D; 2.30.30.30; -; 1.
DR HAMAP; MF_01326_B; Ribosomal_L24_B; 1.
DR InterPro; IPR005824; KOW.
DR InterPro; IPR014722; Rib_uL2_dom2.
DR InterPro; IPR003256; Ribosomal_uL24.
DR InterPro; IPR005825; Ribosomal_uL24_CS.
DR InterPro; IPR041988; Ribosomal_uL24_KOW.
DR InterPro; IPR008991; Translation_prot_SH3-like_sf.
DR NCBIfam; TIGR01079; rplX_bact; 1.
DR PANTHER; PTHR12903:SF0; 39S RIBOSOMAL PROTEIN L24, MITOCHONDRIAL; 1.
DR PANTHER; PTHR12903; MITOCHONDRIAL RIBOSOMAL PROTEIN L24; 1.
DR Pfam; PF00467; KOW; 1.
DR Pfam; PF17136; ribosomal_L24; 1.
DR SMART; SM00739; KOW; 1.
DR SUPFAM; SSF50104; Translation proteins SH3-like domain; 1.
DR PROSITE; PS01108; RIBOSOMAL_L24; 1.
PE 1: Evidence at protein level;
KW 3D-structure {ECO:0007829|PDB:4CE4, ECO:0007829|PDB:4V19};
KW Proteomics identification {ECO:0007829|PeptideAtlas:F1RHJ1};
KW Reference proteome {ECO:0000313|Proteomes:UP000008227};
KW Ribonucleoprotein {ECO:0000256|RuleBase:RU003477};
KW Ribosomal protein {ECO:0000256|RuleBase:RU003477,
KW ECO:0000313|EMBL:HDB48432.1}.
FT DOMAIN 55..82
FT /note="KOW"
FT /evidence="ECO:0000259|SMART:SM00739"
FT REGION 20..45
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 216 AA; 24851 MW; E4B30636924C0640 CRC64;
MRLSALLALA SKVTLPPNYR YGMSRPGSLS DKRKNPPGTR RRRVPVEPIS DEDWHLFCGD
KVEILEGKDA GKQGKVVQVI RQRNWVVVEG LNTHYRYVGK TVDYRGTMIP SEAPLLHNQV
KLVDPTDRKP TDVEWRFTEA GERVRVSTRS GRIIPKPEFP RADGIVPETW IDGPKDTSVE
DALEKTYVPR LKTLEEEVME AMGIQETRRH KKVYWY
//
