ID F1RI50_PIG Unreviewed; 724 AA.
AC F1RI50;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2022, sequence version 3.
DT 27-MAR-2024, entry version 87.
DE SubName: Full=Forkhead box K1 {ECO:0000313|Ensembl:ENSSSCP00000008096.4};
GN Name=FOXK1 {ECO:0000313|Ensembl:ENSSSCP00000008096.4,
GN ECO:0000313|VGNC:VGNC:88214};
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00000008096.4, ECO:0000313|Proteomes:UP000008227};
RN [1] {ECO:0000313|Ensembl:ENSSSCP00000008096.4, ECO:0000313|Proteomes:UP000008227}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000008096.4,
RC ECO:0000313|Proteomes:UP000008227};
RG Porcine genome sequencing project;
RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSSCP00000008096.4}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PROSITE-ProRule:PRU00089}.
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DR AlphaFoldDB; F1RI50; -.
DR PaxDb; 9823-ENSSSCP00000008096; -.
DR Ensembl; ENSSSCT00000008315.5; ENSSSCP00000008096.4; ENSSSCG00000007576.5.
DR VGNC; VGNC:88214; FOXK1.
DR eggNOG; KOG2294; Eukaryota.
DR GeneTree; ENSGT00940000159507; -.
DR HOGENOM; CLU_022344_0_0_1; -.
DR OrthoDB; 5385885at2759; -.
DR TreeFam; TF325718; -.
DR Proteomes; UP000008227; Chromosome 3.
DR Bgee; ENSSSCG00000007576; Expressed in blood and 42 other cell types or tissues.
DR ExpressionAtlas; F1RI50; baseline and differential.
DR GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0071889; F:14-3-3 protein binding; IEA:Ensembl.
DR GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; IEA:Ensembl.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IEA:Ensembl.
DR GO; GO:0061621; P:canonical glycolysis; IEA:Ensembl.
DR GO; GO:0001678; P:intracellular glucose homeostasis; IEA:Ensembl.
DR GO; GO:0010507; P:negative regulation of autophagy; IEA:Ensembl.
DR GO; GO:0045893; P:positive regulation of DNA-templated transcription; IEA:Ensembl.
DR GO; GO:0010906; P:regulation of glucose metabolic process; IEA:Ensembl.
DR GO; GO:0042594; P:response to starvation; IEA:Ensembl.
DR CDD; cd20054; FH_FOXK1; 1.
DR Gene3D; 2.60.200.20; -; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR047394; FH_FOXK1.
DR InterPro; IPR000253; FHA_dom.
DR InterPro; IPR001766; Fork_head_dom.
DR InterPro; IPR008984; SMAD_FHA_dom_sf.
DR InterPro; IPR018122; TF_fork_head_CS_1.
DR InterPro; IPR030456; TF_fork_head_CS_2.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR45881; CHECKPOINT SUPPRESSOR 1-LIKE, ISOFORM A-RELATED; 1.
DR PANTHER; PTHR45881:SF4; FORKHEAD BOX PROTEIN K1; 1.
DR Pfam; PF00498; FHA; 1.
DR Pfam; PF00250; Forkhead; 1.
DR PRINTS; PR00053; FORKHEAD.
DR SMART; SM00339; FH; 1.
DR SMART; SM00240; FHA; 1.
DR SUPFAM; SSF49879; SMAD/FHA domain; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50006; FHA_DOMAIN; 1.
DR PROSITE; PS00657; FORK_HEAD_1; 1.
DR PROSITE; PS00658; FORK_HEAD_2; 1.
DR PROSITE; PS50039; FORK_HEAD_3; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00089};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00089}; Reference proteome {ECO:0000313|Proteomes:UP000008227};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 110..162
FT /note="FHA"
FT /evidence="ECO:0000259|PROSITE:PS50006"
FT DOMAIN 292..387
FT /note="Fork-head"
FT /evidence="ECO:0000259|PROSITE:PS50039"
FT DNA_BIND 292..387
FT /note="Fork-head"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00089"
FT REGION 36..58
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 399..419
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 672..724
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 672..691
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 724 AA; 74991 MW; 8FB07C635387CDDD CRC64;
MAEVGEDSGA RALLALRSAP CSPMLCAAAA AAAAFPAAAP PPPPAQPPPP PPPLPPPPPP
PPGAIAGAAG GAAGEALVAA AAASVRRSPG PALARLEGRE FEFLMRQPSV TIGRNSSQGS
VDLSMGLSSF ISRRHLQLSF QEPHFYLRCL GKNGVFVDGA FQRRGAPALQ LPKQCTLRFP
STAIKIQFTS LYHQEEAPAS PLRPLYPQIS PLKIHIPEPD LRSLVSPVPS PTGTISVPNS
CPASPRGAGS SGYRFVQNVT SDLQLAAEFA AKAASEQQAE ASGGDSPKDE SKPPYSYAQL
IVQAISSAQD RQLTLSGIYA HITKHYPYYR TADKGWQNSI RHNLSLNRYF IKVPRSQEEP
GKGSFWRIDP ASEAKLVEQA FRKRRQRGTC FRTPFGPLSS RSAPASPTHP GLMSPRSSGL
QTPECLSREG SPIPHDPDFG SKLASVPEYR YSQSAPGSPV SAQPVIMAVP PRPPSLVAKP
VAYMPASIVT AQQPAGHAIH VVQQAPPVTM LRVVTTSASS ANGYILASQA SAGATHEAAG
TAVLDLGSEA RGLEEKPTIA FATIPAASRV IQTVASQMAP GVPGHTVTIL QPATPVTIGQ
HHLPVRAVTQ NGKHAVPTNS LAGNAYALTS PLQLLAAQAS SSTPVVVTRV CEVGPEEPAA
AAAAAAAAVA TTATPTPTTP TATSASSTGE PEVKRSRVEE PVGTGTTQAG VITAAGPQGP
GTGE
//
