ID F1RJU6_PIG Unreviewed; 934 AA.
AC F1RJU6;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2022, sequence version 5.
DT 27-MAR-2024, entry version 88.
DE RecName: Full=Neurofilament medium polypeptide {ECO:0000256|ARBA:ARBA00015894};
DE AltName: Full=160 kDa neurofilament protein {ECO:0000256|ARBA:ARBA00030258};
DE AltName: Full=Neurofilament 3 {ECO:0000256|ARBA:ARBA00033124};
DE AltName: Full=Neurofilament triplet M protein {ECO:0000256|ARBA:ARBA00032778};
GN Name=NEFM {ECO:0000313|Ensembl:ENSSSCP00000010300.5,
GN ECO:0000313|VGNC:VGNC:111119};
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00000010300.5, ECO:0000313|Proteomes:UP000008227};
RN [1] {ECO:0000313|Ensembl:ENSSSCP00000010300.5, ECO:0000313|Proteomes:UP000008227}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000010300.5,
RC ECO:0000313|Proteomes:UP000008227};
RG Porcine genome sequencing project;
RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSSCP00000010300.5}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the intermediate filament family.
CC {ECO:0000256|RuleBase:RU000685}.
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DR AlphaFoldDB; F1RJU6; -.
DR PeptideAtlas; F1RJU6; -.
DR Ensembl; ENSSSCT00000010576.5; ENSSSCP00000010300.5; ENSSSCG00000009648.5.
DR VGNC; VGNC:111119; NEFM.
DR GeneTree; ENSGT00940000161685; -.
DR HOGENOM; CLU_012560_7_3_1; -.
DR OMA; TTYQDTI; -.
DR TreeFam; TF330122; -.
DR Proteomes; UP000008227; Chromosome 14.
DR Bgee; ENSSSCG00000009648; Expressed in prefrontal cortex and 19 other cell types or tissues.
DR ExpressionAtlas; F1RJU6; baseline.
DR GO; GO:0005882; C:intermediate filament; IEA:UniProtKB-KW.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR Gene3D; 1.20.5.170; -; 1.
DR Gene3D; 1.20.5.500; Single helix bin; 1.
DR Gene3D; 1.20.5.1160; Vasodilator-stimulated phosphoprotein; 1.
DR InterPro; IPR018039; IF_conserved.
DR InterPro; IPR039008; IF_rod_dom.
DR InterPro; IPR006821; Intermed_filament_DNA-bd.
DR InterPro; IPR002957; Keratin_I.
DR PANTHER; PTHR45652; GLIAL FIBRILLARY ACIDIC PROTEIN; 1.
DR PANTHER; PTHR45652:SF3; NEUROFILAMENT MEDIUM POLYPEPTIDE; 1.
DR Pfam; PF00038; Filament; 1.
DR Pfam; PF04732; Filament_head; 1.
DR PRINTS; PR01248; TYPE1KERATIN.
DR SMART; SM01391; Filament; 1.
DR SUPFAM; SSF64593; Intermediate filament protein, coiled coil region; 2.
DR PROSITE; PS00226; IF_ROD_1; 1.
DR PROSITE; PS51842; IF_ROD_2; 1.
PE 1: Evidence at protein level;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Intermediate filament {ECO:0000256|ARBA:ARBA00022754,
KW ECO:0000256|RuleBase:RU000685};
KW Proteomics identification {ECO:0007829|PeptideAtlas:F1RJU6};
KW Reference proteome {ECO:0000313|Proteomes:UP000008227}.
FT DOMAIN 101..412
FT /note="IF rod"
FT /evidence="ECO:0000259|PROSITE:PS51842"
FT REGION 1..51
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 486..869
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 119..244
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 296..383
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 526..548
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 549..563
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 564..583
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 584..849
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 934 AA; 103975 MW; C9330C3E3FCE256E CRC64;
MSYTLDSLGN PSAYRRGTET RSSFSRVSGS PSSGFRSQSW SRGSPSTVSS SYKRSALAPR
LTYSSAMLSS AESSLDFSQS SSLLNGGSGP GGDYKLSRSN EKEQLQGLND RFAGYIEKVH
YLEQQNKEIE AEIQALRQKQ ASHAQLGDAY DQEIRELRAT LELVNHEKAQ VQLDSDHLEE
DIHRLKERFE EEARLRDDTE AAIRALRKDI EEASLVKVEL DKKVQSLQDE VAFLRSNHEE
EVADLLAQIQ ASHITVERKD YLKTDISSAL KEIRSQLECH SDQNMHQAEE WFKCRYAKLT
EAAEQNKEAI RSAKEEIAEY RRQLQSKSIE LESVRGTKES LERQLSDIEE RHNHDLSSYQ
DTIQQLENEL RGTKWEMARH LREYQDLLNV KMALDIEIAA YRKLLEGEET RFSTFAGSIT
GPLYTHRQPS ITISSKIQKT KVEAPKLKVQ HKFVEEIIEE TKVEDEKSEM EEALTAIAEE
LAVSMKEEVK EEEAEEKEEK QEAEEVVAAK KSPVKAAAPE LKGEEEGEKE EGEGQEEEEE
EEEEGAKSDQ AEEGGSEKEV SSEKEEGEQE EEGEIEAEGE GEEAEAKEEK KVEEKREEVA
PKEELVAEAK VEKPEKAKSP VSKSPVEEVK PKAEAGVGKG EQKEEVEKVE EEKKEAAKES
PKEEKVEKKE EKPKDLPEKK KAESPVKEEA GKVSPEKAPS PAKEEAGKVS PEKAPSPAKE
EAGKVSPEKA PSPAKEEAGK VSPEKAPSPS KEEAGKVSPE KAPSPSKEEA GKVSPEKAPS
PSKEEAGKVS PEKDAKEEKP QQKKEKVEGE GGKEEGGLKE SRKEDIAING EVEGKEEQET
KEKGSGGEEE KGVVTNGLDL SPGDRSEEKV VVTKKVEKIT SEGGDGATKY ITKSVTVTQK
VEEHEETFEE KLVSTKKVEK VTSHAIVKEV TQSD
//
