ID F1RL39_PIG Unreviewed; 2184 AA.
AC F1RL39;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 4.
DT 27-MAR-2024, entry version 74.
DE SubName: Full=Calcineurin binding protein 1 {ECO:0000313|Ensembl:ENSSSCP00000010735.4};
GN Name=CABIN1 {ECO:0000313|Ensembl:ENSSSCP00000010735.4,
GN ECO:0000313|VGNC:VGNC:86108};
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00000010735.4, ECO:0000313|Proteomes:UP000008227};
RN [1] {ECO:0000313|Ensembl:ENSSSCP00000010735.4, ECO:0000313|Proteomes:UP000008227}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000010735.4,
RC ECO:0000313|Proteomes:UP000008227};
RG Porcine genome sequencing project;
RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSSCP00000010735.4}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_013838592.1; XM_013983138.1.
DR PaxDb; 9823-ENSSSCP00000010735; -.
DR Ensembl; ENSSSCT00000011023.5; ENSSSCP00000010735.4; ENSSSCG00000010062.5.
DR GeneID; 100157110; -.
DR CTD; 23523; -.
DR VGNC; VGNC:86108; CABIN1.
DR eggNOG; ENOG502QPUI; Eukaryota.
DR GeneTree; ENSGT00390000008529; -.
DR HOGENOM; CLU_000786_0_0_1; -.
DR OrthoDB; 8630at2759; -.
DR TreeFam; TF323227; -.
DR Proteomes; UP000008227; Chromosome 14.
DR Bgee; ENSSSCG00000010062; Expressed in testis and 44 other cell types or tissues.
DR ExpressionAtlas; F1RL39; baseline and differential.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0006325; P:chromatin organization; IEA:InterPro.
DR CDD; cd13839; MEF2_binding; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 2.
DR InterPro; IPR033053; Hir3/CABIN1.
DR InterPro; IPR015134; MEF2-bd.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR PANTHER; PTHR15502; CALCINEURIN-BINDING PROTEIN CABIN 1-RELATED; 1.
DR PANTHER; PTHR15502:SF7; CALCINEURIN-BINDING PROTEIN CABIN-1; 1.
DR Pfam; PF09047; MEF2_binding; 1.
DR SMART; SM00028; TPR; 5.
DR SUPFAM; SSF48452; TPR-like; 2.
DR PROSITE; PS50005; TPR; 2.
PE 4: Predicted;
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000008227};
KW TPR repeat {ECO:0000256|PROSITE-ProRule:PRU00339}.
FT REPEAT 90..123
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 124..157
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT DOMAIN 2120..2154
FT /note="Calcineurin-binding protein cabin-1 MEF2-binding"
FT /evidence="ECO:0000259|Pfam:PF09047"
FT REGION 361..400
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1299..1494
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1666..1850
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1945..2095
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2108..2128
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2160..2184
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 371..400
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1299..1321
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1329..1347
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1356..1370
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1371..1402
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1427..1443
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1739..1754
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1808..1822
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1832..1850
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2051..2070
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2170..2184
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2184 AA; 241994 MW; D0A5EC8E7AA46D2B CRC64;
MIRIAALNAS STVEDDHEGS FKSHKTQTKE AQEAEAFALY HKALDLQKHD RFEESAKAYH
ELLEARLLRE AVSSGDEKEG LKHPGLMLKY STYKNLAQLA AQREDLETAM EFYLEAVMLD
STDVNLWYKI GHVALRLTRV PLARHAFEEG LRCNPDHWPC LDNLITVLYT LSDYTTCLYF
ICKALEKDCR YSKGLVLKEK IFEEQPCLRK DSLRMFLKCD MSIHDVSVSA AESQAIVDEA
LGLRRRRQAL TIREKEPDLK LVQPIPFLTW KCLGESLLAT YNHLSTCEPP RPSLGKRIDL
SDYQDPSQPL LSSVGVAPVS ATQPSPASAS PAATVAEPVL SYTPVATASF PLHSPSLLET
GLPAGDVSGG DKSKKGVKRK KISEESGETA KRRSARVRNT KCKKEEKVDF QELLVKFLPS
RLRKLDPEEE DDPFNNYEVP SEAKLESFPS VGPHRLSFDS ATFMESERQD VHAFLLENLT
NGGILELLVR YLKSMGHRFL LRWPPGLAEV VLSIYHSWRR HSASLPNPLL RDCSSQHIKD
MMLMSLSCME LQLDQWLLTK GRSSAVSPRS CPAGVVNSRF GPDFPGTHFL GDLLQLSFAS
SQRDLFEDGW LEFVVRVYWL KARFLALQGD MEQALENYDI CTEMLQRSSA ICTQPGAQQR
DIVIRLPNLH NDSVVSLEEI DKNLRSLERC QSLEETQRLY EAGDHKAVVR LLRPTLCPSG
FDRAKHLEFM TSVPERPAQL LLLQDSLLRL EDHQQCFECS DVALNEAVQQ MVNASDATAK
EEWVATVTQL LLGIEQALSA DSGGGILKDS SSTTGLTRLT NNLIQVIDCS MAVQEEPKEP
HVSSVLPWII LHRIIRQEED TFHSLCHQQQ LQNPVDEVMA EPPMLPSSLM LLNTAHEYLG
RRSWCCNSDG ALLRFYVRVL QKELAASPSE DTHPYKEELE TALEQCFYCL YSYPSKKSKA
RYLEEHSAQQ VDLIWEDALF MFEYFKPKTL PEFDSYKTST VSADLANLLK RIATIVPRTE
RPALSLDKVS AYIEGTSAEV PCLPEGADPS PPVVNELYYL LADYHFKNKE QSKAIKFYMH
DICICPNRFD SWAGMALARA SRIQDKLNSN ELKSDGPIWK HATPVLNCFR RALEIDSSNL
SLWIEFGTMS YALHSFASRQ LKQWRPELPP ELVQQMEDRR DSMLETARHC FTSAARCEGD
GDEEEWLIHY MLGKVAEKQQ QPPTVYLRHY RQAGHYLHEE AARYPKKIHY HNPPELAMEA
LEVYFRLHAS ILKLLGRPDS GVGAEVLVSF MKEAAEGPFA RGEEKNAPKA SEKEKACLVD
EDSHSSAGTL PGPGASLPSS GPGLTSPPYT ATPIDHDYVK CKKPHQQATP DERSQDSTAV
ALSDSSSTQD FFNEPSSSLE GSRKPLTEKR PPAPSSHAGP PGKDLQGPAE ERGKPEEPLE
TMEGIRVTEQ GSQKPAADPS GPGTPAKPPV SAAATWDGRR RGEPPGEPAA FPQGLPAGAE
EQRQFLTEQC VASLRLCLSR FPQHYKSLYR LAFLYTYSKT HRNLQWARDV LLGSGIPWQQ
LQHMPAQGLF CERNKTNFFN GIWRIPVDEI DRPGSFAWHM NRSIVLLLKV LAQLRDHSTL
LKVSSMLQRT PDQGKKYLRD ADRQVLAQRA FILTVKVLED TLSELAEGSE RPGPKACGLS
GARMTTDVSH KASPEDGQEG LPHPKKPPLA DGSGPGTEPG GKAGPLTHRP VAMDAGEGTD
QGGERKDREN PRAGPTEPMD TGEAAARCSD SERVPPLQPG RPLRDRGPES RPAELSLEEL
SISTRQQPGP PGPAPPATAP TATTPRPRVG SHPEEAPPRP SRKRKLLEDT ESGKTLLLDA
YRVWQQGQKG MAYDLGRIER IMAETYMLIK QVDEEAALEQ AVKFCQVHLG AAAQRQAAGD
TPTTPKHPKD SRENFFPAAV ALTASEPMPT DVLQRPSDAH TKPRPVPATT SAVITCPPSA
SASTPDPAED PGPPQLHRPE ATSLDPEEEL AGEGAEGTGF PPQEPPSSEQ VKTAPEGPPA
EPHCWPAEAT SRTGTEPTCS QGSSCKVPSG GSAQPPEGHL GKTEPSRAKS RLLPNMPKLV
IPSAATKFPP EITVTPPTPT LLSPKGSISE ETKQKLKSAI LSAQSAANVR KESLCQPALE
VLETSSQESS LESETDEDDD YMDV
//
