ID F1RL85_PIG Unreviewed; 445 AA.
AC F1RL85;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 03-MAY-2011, sequence version 1.
DT 27-MAR-2024, entry version 75.
DE RecName: Full=Glutamate-rich WD repeat-containing protein 1 {ECO:0000256|ARBA:ARBA00040876};
GN Name=GRWD1 {ECO:0000313|Ensembl:ENSSSCP00000003392.2,
GN ECO:0000313|VGNC:VGNC:88712};
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00000003392.2, ECO:0000313|Proteomes:UP000008227};
RN [1] {ECO:0000313|Ensembl:ENSSSCP00000003392.2, ECO:0000313|Proteomes:UP000008227}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000003392.2,
RC ECO:0000313|Proteomes:UP000008227};
RG Porcine genome sequencing project;
RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSSCP00000003392.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR RefSeq; XP_003127319.1; XM_003127271.3.
DR AlphaFoldDB; F1RL85; -.
DR SMR; F1RL85; -.
DR STRING; 9823.ENSSSCP00000003392; -.
DR PaxDb; 9823-ENSSSCP00000003392; -.
DR PeptideAtlas; F1RL85; -.
DR Ensembl; ENSSSCT00000003475.5; ENSSSCP00000003392.2; ENSSSCG00000003134.5.
DR GeneID; 100521273; -.
DR KEGG; ssc:100521273; -.
DR CTD; 83743; -.
DR VGNC; VGNC:88712; GRWD1.
DR eggNOG; KOG0302; Eukaryota.
DR GeneTree; ENSGT00550000075124; -.
DR HOGENOM; CLU_025272_1_1_1; -.
DR InParanoid; F1RL85; -.
DR OMA; RHWKPNA; -.
DR OrthoDB; 260921at2759; -.
DR TreeFam; TF312982; -.
DR Proteomes; UP000008227; Chromosome 6.
DR Bgee; ENSSSCG00000003134; Expressed in oocyte and 40 other cell types or tissues.
DR ExpressionAtlas; F1RL85; baseline and differential.
DR Genevisible; F1RL85; SS.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005730; C:nucleolus; IBA:GO_Central.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0032991; C:protein-containing complex; IEA:Ensembl.
DR GO; GO:0003682; F:chromatin binding; IEA:Ensembl.
DR GO; GO:0003688; F:DNA replication origin binding; IEA:Ensembl.
DR GO; GO:0042393; F:histone binding; IEA:Ensembl.
DR GO; GO:0006260; P:DNA replication; IEA:Ensembl.
DR GO; GO:0006334; P:nucleosome assembly; IEA:Ensembl.
DR GO; GO:0006337; P:nucleosome disassembly; IEA:Ensembl.
DR GO; GO:0042254; P:ribosome biogenesis; IBA:GO_Central.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR InterPro; IPR022052; Histone-bd_RBBP4_N.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR45903; GLUTAMATE-RICH WD REPEAT-CONTAINING PROTEIN 1; 1.
DR PANTHER; PTHR45903:SF1; GLUTAMATE-RICH WD REPEAT-CONTAINING PROTEIN 1; 1.
DR Pfam; PF12265; CAF1C_H4-bd; 1.
DR Pfam; PF00400; WD40; 3.
DR PRINTS; PR00320; GPROTEINBRPT.
DR SMART; SM00320; WD40; 5.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 3.
DR PROSITE; PS50294; WD_REPEATS_REGION; 3.
PE 4: Predicted;
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000008227};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT DOMAIN 45..112
FT /note="Histone-binding protein RBBP4 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF12265"
FT REPEAT 256..291
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 303..337
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 348..382
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REGION 1..41
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 110..138
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..22
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 121..136
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 445 AA; 49251 MW; 2155D4596D859170 CRC64;
MAARKGRRRT CETGEPMEAE SHDAGSEGPP QVYLPGRGPP LREGEELVMD EEAYVLYHRA
QTGAPCLSFD IVRDHLGDNR TELPLTLYLC AGTQAESAQS NRLMMLRMHN LHGTKPPPSE
GSDEEEEEDE EDEEERKPQL ELAMVPHYGG INRVRVSWLG EEPVAGVWSE KGQVEVFALR
RLLQVVDDPQ ALATFLRDEQ ARVKPIFAFS GHMGEGFALD WSPRVPGRLL TGDCQKNIHL
WTPTDSGSWH VDQRPFVGHT RSVEDLQWSP TEDTVFASCS ADASIRIWDI RAAPSKACML
TTPAAHNGDV NVISWSRQEP FLLSGGDDGA LKVWDLRQFK SGSPVATFKQ HVAPVTSVEW
HPQDSGVFAA SGADNQITQW DLAVERDPEA GDTETDPGLV GLPQQLLFVH QGETDLKELH
WHPQCPGVLV STALSGFTVF RTISV
//
