ID F1RLN9_PIG Unreviewed; 940 AA.
AC F1RLN9;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 4.
DT 27-MAR-2024, entry version 83.
DE SubName: Full=Myosin XVI {ECO:0000313|Ensembl:ENSSSCP00000010189.4};
GN Name=MYO16 {ECO:0000313|Ensembl:ENSSSCP00000010189.4,
GN ECO:0000313|VGNC:VGNC:109445};
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00000010189.4, ECO:0000313|Proteomes:UP000008227};
RN [1] {ECO:0000313|Ensembl:ENSSSCP00000010189.4, ECO:0000313|Proteomes:UP000008227}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000010189.4,
RC ECO:0000313|Proteomes:UP000008227};
RG Porcine genome sequencing project;
RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSSCP00000010189.4}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Myosin family. {ECO:0000256|PROSITE-ProRule:PRU00782}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00782}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; F1RLN9; -.
DR SMR; F1RLN9; -.
DR STRING; 9823.ENSSSCP00000010189; -.
DR PaxDb; 9823-ENSSSCP00000010189; -.
DR Ensembl; ENSSSCT00000010461.5; ENSSSCP00000010189.4; ENSSSCG00000009543.5.
DR VGNC; VGNC:109445; MYO16.
DR eggNOG; KOG0164; Eukaryota.
DR GeneTree; ENSGT00940000158920; -.
DR HOGENOM; CLU_013794_0_0_1; -.
DR InParanoid; F1RLN9; -.
DR Proteomes; UP000008227; Chromosome 11.
DR Bgee; ENSSSCG00000009543; Expressed in right lobe of liver and 21 other cell types or tissues.
DR GO; GO:0016459; C:myosin complex; IBA:GO_Central.
DR GO; GO:0005654; C:nucleoplasm; IBA:GO_Central.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; IBA:GO_Central.
DR GO; GO:0051015; F:actin filament binding; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003774; F:cytoskeletal motor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0019903; F:protein phosphatase binding; IBA:GO_Central.
DR GO; GO:2000134; P:negative regulation of G1/S transition of mitotic cell cycle; IBA:GO_Central.
DR GO; GO:0048812; P:neuron projection morphogenesis; IBA:GO_Central.
DR GO; GO:0043491; P:phosphatidylinositol 3-kinase/protein kinase B signal transduction; IBA:GO_Central.
DR Gene3D; 1.10.10.820; -; 1.
DR Gene3D; 1.20.58.530; -; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 2.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 1.
DR Gene3D; 1.20.120.720; Myosin VI head, motor domain, U50 subdomain; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR001609; Myosin_head_motor_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR47335; UNCONVENTIONAL MYOSIN-XVI; 1.
DR PANTHER; PTHR47335:SF1; UNCONVENTIONAL MYOSIN-XVI; 1.
DR Pfam; PF12796; Ank_2; 2.
DR Pfam; PF00063; Myosin_head; 1.
DR PRINTS; PR00193; MYOSINHEAVY.
DR SMART; SM00248; ANK; 5.
DR SMART; SM00242; MYSc; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 4.
DR PROSITE; PS50088; ANK_REPEAT; 4.
DR PROSITE; PS51456; MYOSIN_MOTOR; 1.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|PROSITE-ProRule:PRU00782};
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Myosin {ECO:0000256|ARBA:ARBA00023123, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00782}; Reference proteome {ECO:0000313|Proteomes:UP000008227}.
FT REPEAT 92..124
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 125..157
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 221..253
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 254..286
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 401..940
FT /note="Myosin motor"
FT /evidence="ECO:0000259|PROSITE:PS51456"
FT BINDING 497..504
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
SQ SEQUENCE 940 AA; 105721 MW; 7460051A0DD59619 CRC64;
MEIDQCLLES LPLGQRQRLV KRMRCEQVKA YYEREKAFQK QEGLLKRLKH GRTQKVHFNL
ADMLQDAIIH HDDKEALRLL KEAADPHLLV SSGQSLLHLC ARYDNVFIAE ILIDRGANVN
QQDEDFWTPM HIACACDNPD IVLLLVLAGA NVLLQDVNGN TPLDYAMEGT ESSSILLTYL
DENGVDLTSL RQMKLQRPMS MLADVKRFLA CGGNIDEKND DGVTLLHMAS ASGYKEVVAL
LLEHGGDLNV TDNQHWTPLH LAAKYGQTSV VKLLLVHQAD PQLLNCNEEK ASDVAASEFI
EEMLLKAEIA WEGKMKEPFC APTLAQEEPY EEVVSDLPAL PSKLSPLVLP IAKQDSLLEK
DIMFKDATKG LCRRQSQDRT LENAAVNGPS KPEQVKLMPP APNDDLATLS ELTDSSLLYE
IQKRFGNNQI YTFIGDILLL VNPFKEIPIY STMVSQLYLS QSGQPCSSLP PHLFSCAERA
FHQLLQEQRP QCFILSGERG SGKSEASKQI MTHLTRRSGS SRTPFDSKLK HVMGILEAFG
HAKTTLNDLS SCFIKYVELQ FCEKKKHLAG ARIYTYMLEK SRLVSQPLGQ SNFLIFYLLM
DGLSAEEKYG LHLNNLCAHR YLNQSLRDGA TAEPSLNREK LAVLKQALHA VGFSHLEVEN
LFVILAAILH GDIRFTALTE ADSALVSDLQ LLEQVAGMLQ VPTDELVSAL TTDVHYFKGE
MITRRNTVEM AEFYRDLLAK SIYGRLFSFL VNTVNYFLHN QDEPSSLHTW DIGILDIFGF
EEFQKNEFEQ LCVNMTNEKL HHYIHEVLFL QEQTDCVQEG VPMETAYSLG NQTGVLDFFF
QKPSGFLSLL DEESQMMWSM EPTLPKKLQS LLESSNTNAV YSPVKDGNGN LAVKDQGAAF
TVMHYAGRVM YDIVGAIEKN KDSLSQNLLF VMKSCRYTSV
//
