ID F1RP86_PIG Unreviewed; 555 AA.
AC F1RP86;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 03-MAY-2011, sequence version 1.
DT 27-MAR-2024, entry version 75.
DE SubName: Full=Sialic acid-binding Ig-like lectin 5 {ECO:0000313|EMBL:HDB23241.1};
GN Name=SIGLEC5 {ECO:0000313|Ensembl:ENSSSCP00000041048.1};
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00000041048.1, ECO:0000313|Proteomes:UP000008227};
RN [1] {ECO:0000313|Ensembl:ENSSSCP00000041048.1, ECO:0000313|Proteomes:UP000008227}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000041048.1,
RC ECO:0000313|Proteomes:UP000008227};
RG Porcine genome sequencing project;
RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:HDB23241.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=30723633; DOI=.7717/peerj.6374;
RA Gilbert D.G.;
RT "Genes of the pig, Sus scrofa, reconstructed with EvidentialGene.";
RL PeerJ 7:E6374-E6374(2019).
RN [3] {ECO:0000313|Ensembl:ENSSSCP00000041048.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the immunoglobulin superfamily. SIGLEC (sialic
CC acid binding Ig-like lectin) family. {ECO:0000256|ARBA:ARBA00038361}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; DQIR01167764; HDB23241.1; -; Transcribed_RNA.
DR RefSeq; XP_003127434.1; XM_003127386.3.
DR PaxDb; 9823-ENSSSCP00000003512; -.
DR Ensembl; ENSSSCT00000038574.3; ENSSSCP00000041048.1; ENSSSCG00000003236.6.
DR GeneID; 100514653; -.
DR KEGG; ssc:100514653; -.
DR CTD; 8778; -.
DR eggNOG; ENOG502S41V; Eukaryota.
DR GeneTree; ENSGT01080000257333; -.
DR HOGENOM; CLU_024444_6_2_1; -.
DR OMA; GSRQKPW; -.
DR OrthoDB; 5350608at2759; -.
DR Proteomes; UP000008227; Chromosome 6.
DR Bgee; ENSSSCG00000003236; Expressed in blood and 29 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0030246; F:carbohydrate binding; IEA:UniProtKB-KW.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR Gene3D; 2.60.40.10; Immunoglobulins; 3.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR013106; Ig_V-set.
DR PANTHER; PTHR12035; SIALIC ACID BINDING IMMUNOGLOBULIN-LIKE LECTIN; 1.
DR PANTHER; PTHR12035:SF103; SIALIC ACID-BINDING IG-LIKE LECTIN 5; 1.
DR Pfam; PF07686; V-set; 1.
DR SMART; SM00409; IG; 2.
DR SMART; SM00408; IGc2; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 4.
DR PROSITE; PS50835; IG_LIKE; 3.
PE 3: Inferred from homology;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Lectin {ECO:0000256|ARBA:ARBA00022734, ECO:0000313|EMBL:HDB23241.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000008227};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..555
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5015090493"
FT TRANSMEM 444..466
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 3..118
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 148..231
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 238..332
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT REGION 73..100
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 473..555
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 535..555
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 555 AA; 60327 MW; 4B51BA38CF94E143 CRC64;
MVPLLLLLLL LLWGGSLQQD QGFWLQVQES VTVQECLGVH VTCSFSFSWS YWFSPEYLFI
YWFREGDNTR LGEPVATNNP HRPVNPQTRD RFQLSGDPQN KDCSLSIRDA RMSDTGVYVL
RLEEEHRIKH TYTDKKLKVQ VTALTEKPDI RFLEPLESGR PTNLTCSLPP VCDGGRLVHF
SWAGAALDAV DPEALGSSVL TLTPRPQDHG TNLTCQVKLQ GAQVTTERTI QLNVSYAPWN
LTINVSFRNV TVLKILQNTS SLFILEDQAL QLLCVADGNP PAQLSWFRGS PAPNATPISS
TTILELPGVG TVPGEVTCRA QNPLGSQNLS LSLLVVSPPQ LLGPSCSWED RGLHCSCSSR
AQPAPSLHWR LGEGLLDGNF SNASIKVTSS STGPWANSSL SLGEGLSSSL RLSCEAQNVY
GSQGATVLLL PGTSGSLTGA VPGALGGAGA MAVLSLCLCL IFFCLVKRRR RQAARTPKGM
DDEDPVMGTV AWGSRQKPRP DSPADQAPSP AEDAEPPGEQ EELHYASLSF QEMKSREPGD
QEATSTEYSE IRKSK
//
