ID F1RPA7_PIG Unreviewed; 532 AA.
AC F1RPA7;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 3.
DT 27-MAR-2024, entry version 73.
DE SubName: Full=Glycoprotein 2 {ECO:0000313|Ensembl:ENSSSCP00000008391.3};
DE SubName: Full=Pancreatic secretory granule membrane major glycoprotein GP2 isoform 1 {ECO:0000313|EMBL:ANV20591.1};
DE SubName: Full=Pancreatic secretory granule membrane major glycoprotein GP2 isoform 2 {ECO:0000313|EMBL:HCZ84793.1};
GN Name=GP2 {ECO:0000313|Ensembl:ENSSSCP00000008391.3,
GN ECO:0000313|VGNC:VGNC:88565};
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00000008391.3, ECO:0000313|Proteomes:UP000008227};
RN [1] {ECO:0000313|Ensembl:ENSSSCP00000008391.3, ECO:0000313|Proteomes:UP000008227}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000008391.3,
RC ECO:0000313|Proteomes:UP000008227};
RG Porcine genome sequencing project;
RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ANV20591.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Pancreas {ECO:0000313|EMBL:ANV20591.1};
RA Kolenda R., Schierack P.;
RT "Cloning and characterization of porcine pancreatic secretory granule
RT membrane major glycoprotein GP2.";
RL Submitted (FEB-2016) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:HCZ84793.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=30723633; DOI=.7717/peerj.6374;
RA Gilbert D.G.;
RT "Genes of the pig, Sus scrofa, reconstructed with EvidentialGene.";
RL PeerJ 7:E6374-E6374(2019).
RN [4] {ECO:0000313|Ensembl:ENSSSCP00000008391.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; KU665995; ANV20591.1; -; mRNA.
DR EMBL; DQIR01029318; HCZ84793.1; -; Transcribed_RNA.
DR RefSeq; XP_005662159.1; XM_005662102.2.
DR STRING; 9823.ENSSSCP00000008391; -.
DR PaxDb; 9823-ENSSSCP00000008391; -.
DR Ensembl; ENSSSCT00000008612.5; ENSSSCP00000008391.3; ENSSSCG00000007861.5.
DR GeneID; 100303610; -.
DR CTD; 2813; -.
DR VGNC; VGNC:88565; GP2.
DR eggNOG; ENOG502QT6B; Eukaryota.
DR GeneTree; ENSGT00940000156038; -.
DR HOGENOM; CLU_028679_1_0_1; -.
DR OMA; QGYGNPS; -.
DR OrthoDB; 5293157at2759; -.
DR TreeFam; TF330284; -.
DR Reactome; R-SSC-163125; Post-translational modification: synthesis of GPI-anchored proteins.
DR Proteomes; UP000008227; Chromosome 3.
DR Bgee; ENSSSCG00000007861; Expressed in tonsil and 15 other cell types or tissues.
DR GO; GO:0016324; C:apical plasma membrane; IBA:GO_Central.
DR GO; GO:0009986; C:cell surface; IBA:GO_Central.
DR GO; GO:0005768; C:endosome; IEA:Ensembl.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0003823; F:antigen binding; IEA:Ensembl.
DR GO; GO:1990266; P:neutrophil migration; IBA:GO_Central.
DR Gene3D; 2.60.40.4100; Zona pellucida, ZP-C domain; 1.
DR Gene3D; 2.60.40.3210; Zona pellucida, ZP-N domain; 1.
DR InterPro; IPR042235; ZP-C.
DR InterPro; IPR048290; ZP_chr.
DR InterPro; IPR001507; ZP_dom.
DR InterPro; IPR017977; ZP_dom_CS.
DR PANTHER; PTHR14002; ENDOGLIN/TGF-BETA RECEPTOR TYPE III; 1.
DR PANTHER; PTHR14002:SF16; PANCREATIC SECRETORY GRANULE MEMBRANE MAJOR GLYCOPROTEIN GP2; 1.
DR Pfam; PF00100; Zona_pellucida; 1.
DR PRINTS; PR00023; ZPELLUCIDA.
DR SMART; SM00241; ZP; 1.
DR PROSITE; PS00682; ZP_1; 1.
DR PROSITE; PS51034; ZP_2; 1.
PE 1: Evidence at protein level;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Proteomics identification {ECO:0007829|PeptideAtlas:F1RPA7};
KW Reference proteome {ECO:0000313|Proteomes:UP000008227};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..532
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014571222"
FT TRANSMEM 512..531
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 221..479
FT /note="ZP"
FT /evidence="ECO:0000259|PROSITE:PS51034"
SQ SEQUENCE 532 AA; 58072 MW; 03D2C463237AA088 CRC64;
MGSMAPVLGL ALASCILTLA SAEQQGPQNP TKANSYEQVL ECGAPGTPEA EHCFDPCKNY
TLLDDPSRST ENAELAENCD KDLHGWYRFV GTGGEKMPVD CVPVYRCQTA APLWLNGTHP
TVGEGIVNRT ACAHWSGNCC FWKTEVLTKA CQGGYHVYRL ESTPQCNLRY CTDPTTAIVE
NKCEKTCRPE EECRLDNGTW SCFCRKDLNS SDVNSLQPQL DCGAKEMKVS VDKCLLGGLG
FGDSVSAYLQ DRNWNCSSAT QRQDGNWISV VSPAQAGACG NVLERNQTHA IYKNTLSLVN
NFIIRDTILS IGFQCAYPLD MKVSLQTALQ PIVSSLNISV DGAGDFIVRM ALFQDPNYTY
PYEGAAAVLS VESMLYVGAI LEIGDTSHFN LVLRNCYATP SGDRADPVRY FIIRNSCPNQ
RDSTIRVEEN GVSSESRFSV QMFMFAGNYD LVFLHCEVSL CEFLKEQCQP SCSNSQVRGE
GGAIDPARVL DLGPITRRGA QSLGVMSGTP SAAGFLVAWP MLLLPLLLAA LF
//
