ID   F1RRP1_PIG              Unreviewed;       677 AA.
AC   F1RRP1;
DT   03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT   14-DEC-2022, sequence version 4.
DT   27-MAR-2024, entry version 82.
DE   SubName: Full=Myeloperoxidase {ECO:0000313|Ensembl:ENSSSCP00000018691.5};
GN   Name=MPO {ECO:0000313|Ensembl:ENSSSCP00000018691.5,
GN   ECO:0000313|VGNC:VGNC:90328};
OS   Sus scrofa (Pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX   NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00000018691.5, ECO:0000313|Proteomes:UP000008227};
RN   [1] {ECO:0000313|Ensembl:ENSSSCP00000018691.5, ECO:0000313|Proteomes:UP000008227}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000018691.5,
RC   ECO:0000313|Proteomes:UP000008227};
RG   Porcine genome sequencing project;
RL   Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSSSCP00000018691.5}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- COFACTOR:
CC       Name=heme b; Xref=ChEBI:CHEBI:60344;
CC         Evidence={ECO:0000256|ARBA:ARBA00001970};
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DR   AlphaFoldDB; F1RRP1; -.
DR   GlyCosmos; F1RRP1; 5 sites, No reported glycans.
DR   PeptideAtlas; F1RRP1; -.
DR   Ensembl; ENSSSCT00000019199.5; ENSSSCP00000018691.5; ENSSSCG00000017637.6.
DR   VGNC; VGNC:90328; MPO.
DR   GeneTree; ENSGT00940000161343; -.
DR   HOGENOM; CLU_006087_1_1_1; -.
DR   Proteomes; UP000008227; Chromosome 12.
DR   Bgee; ENSSSCG00000017637; Expressed in right lobe of liver and 6 other cell types or tissues.
DR   GO; GO:0020037; F:heme binding; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0004601; F:peroxidase activity; IEA:InterPro.
DR   GO; GO:0006979; P:response to oxidative stress; IEA:InterPro.
DR   CDD; cd09824; myeloperoxidase_like; 1.
DR   Gene3D; 1.10.640.10; Haem peroxidase domain superfamily, animal type; 1.
DR   InterPro; IPR019791; Haem_peroxidase_animal.
DR   InterPro; IPR010255; Haem_peroxidase_sf.
DR   InterPro; IPR037120; Haem_peroxidase_sf_animal.
DR   PANTHER; PTHR11475:SF108; MYELOPEROXIDASE; 1.
DR   PANTHER; PTHR11475; OXIDASE/PEROXIDASE; 1.
DR   Pfam; PF03098; An_peroxidase; 1.
DR   PRINTS; PR00457; ANPEROXIDASE.
DR   SUPFAM; SSF48113; Heme-dependent peroxidases; 1.
DR   PROSITE; PS50292; PEROXIDASE_3; 1.
PE   1: Evidence at protein level;
KW   Heme {ECO:0000256|PIRSR:PIRSR619791-2};
KW   Iron {ECO:0000256|PIRSR:PIRSR619791-2};
KW   Metal-binding {ECO:0000256|PIRSR:PIRSR619791-2};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   Proteomics identification {ECO:0007829|PeptideAtlas:F1RRP1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008227};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           25..677
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5036463620"
FT   BINDING         432
FT                   /ligand="heme b"
FT                   /ligand_id="ChEBI:CHEBI:60344"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="axial binding residue"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR619791-2"
SQ   SEQUENCE   677 AA;  76644 MW;  E653D3D7A3F5FC5C CRC64;
     MKLLLALAGL LAFLVLLQPS EVAALGHVET SVVLTCMEEA KRLVDKAYKE QRESIKQRLR
     SGSASPMELL SYFKQPVAAT RTAVRAADYL HVALGLLERK LRSLWPGPFN VTDVLTPVQM
     NLLSKTSGCA YQDLGVRCPE KDKYRTITGQ CNNRCSHWGR MAIPCPSARA VSNAIVRFPT
     EQLTPDQERS LLFMQWGQLL DHDLDFTPEP AARVAFLTGI NCETSCLQQP PCFPLKIPPN
     DPRIKNQRDC IPFFRSCPIN ALTSFVDASM VYGSEDPLAM KLRNLTNQLG LLAVNIHFRD
     NGRALLPFDN MHDDPCLLTN RSANIPLLLP QGDSRASEMP GLTSLHTLLL REHNRLATQL
     KRLNPRWDGE RLYQEARKIV GAMVQIITYR DYLPLVLGPE AMKKYLPKYR CYNDSVDPRI
     ANVFTNAFRY GHTLIQPFTF RLDSRYRPMQ PNPRVPLSKA FFATWRVVLE GGIDPLLRGL
     MATPAKLNRQ NQIVVDEIRE RLFEQVMRIG LDLPALNMQR SRDHGLPGYK AWRRFCGLPE
     PSTVGELGTV LKNLDLARKL MAQYGTPANI DIWMGGVAEP LNRKGRVGPL LACLIGTQFR
     KLRDGDRFWW QNKGVFSKQQ QQALAKISLS RIICDNTGIT VVSKKNIFMS NRFPRDFVNC
     STLPALNLTS WRVLETY
//