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Database: UniProt
Entry: F1RRX8_PIG
LinkDB: F1RRX8_PIG
Original site: F1RRX8_PIG 
ID   F1RRX8_PIG              Unreviewed;       440 AA.
AC   F1RRX8;
DT   03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT   03-MAY-2011, sequence version 1.
DT   18-SEP-2019, entry version 62.
DE   SubName: Full=Gamma-aminobutyric acid receptor subunit pi isoform X1 {ECO:0000313|EMBL:HCZ90067.1};
GN   Name=GABRP {ECO:0000313|Ensembl:ENSSSCP00000024984};
OS   Sus scrofa (Pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Suina; Suidae;
OC   Sus.
OX   NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00000024984, ECO:0000313|Proteomes:UP000008227};
RN   [1] {ECO:0000313|Ensembl:ENSSSCP00000024984, ECO:0000313|Proteomes:UP000008227}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000024984};
RG   Porcine genome sequencing project;
RL   Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSSSCP00000024984}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2012) to UniProtKB.
RN   [3] {ECO:0000313|EMBL:HCZ90067.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=30723633; DOI=.7717/peerj.6374;
RA   Gilbert D.G.;
RT   "Genes of the pig, Sus scrofa, reconstructed with EvidentialGene.";
RL   PeerJ 7:E6374-E6374(2019).
CC   -!- SIMILARITY: Belongs to the ligand-gated ion channel (TC 1.A.9)
CC       family. {ECO:0000256|RuleBase:RU000687,
CC       ECO:0000256|SAAS:SAAS00978283}.
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DR   EMBL; AEMK02000102; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; DQIR01034592; HCZ90067.1; -; Transcribed_RNA.
DR   RefSeq; XP_003134108.1; XM_003134060.4.
DR   STRING; 9823.ENSSSCP00000024984; -.
DR   PaxDb; F1RRX8; -.
DR   Ensembl; ENSSSCT00000026800; ENSSSCP00000024984; ENSSSCG00000021902.
DR   GeneID; 100525792; -.
DR   KEGG; ssc:100525792; -.
DR   CTD; 2568; -.
DR   eggNOG; KOG3643; Eukaryota.
DR   eggNOG; ENOG410XPWH; LUCA.
DR   GeneTree; ENSGT00940000160813; -.
DR   InParanoid; F1RRX8; -.
DR   KO; K05189; -.
DR   OrthoDB; 480926at2759; -.
DR   TreeFam; TF315453; -.
DR   Proteomes; UP000008227; Chromosome 16.
DR   Bgee; ENSSSCG00000021902; Expressed in 1 organ(s), highest expression level in lung.
DR   Genevisible; F1RRX8; SS.
DR   GO; GO:1902711; C:GABA-A receptor complex; IBA:GO_Central.
DR   GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR   GO; GO:0043005; C:neuron projection; IBA:GO_Central.
DR   GO; GO:0045202; C:synapse; IBA:GO_Central.
DR   GO; GO:0005230; F:extracellular ligand-gated ion channel activity; IEA:InterPro.
DR   GO; GO:0004890; F:GABA-A receptor activity; IEA:InterPro.
DR   GO; GO:0007268; P:chemical synaptic transmission; IBA:GO_Central.
DR   GO; GO:0034220; P:ion transmembrane transport; IBA:GO_Central.
DR   GO; GO:0050877; P:nervous system process; IBA:GO_Central.
DR   GO; GO:0042391; P:regulation of membrane potential; IBA:GO_Central.
DR   GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR   Gene3D; 2.70.170.10; -; 1.
DR   InterPro; IPR006028; GABAA/Glycine_rcpt.
DR   InterPro; IPR008100; GABAAp_rcpt.
DR   InterPro; IPR006202; Neur_chan_lig-bd.
DR   InterPro; IPR036734; Neur_chan_lig-bd_sf.
DR   InterPro; IPR006201; Neur_channel.
DR   InterPro; IPR036719; Neuro-gated_channel_TM_sf.
DR   InterPro; IPR006029; Neurotrans-gated_channel_TM.
DR   InterPro; IPR018000; Neurotransmitter_ion_chnl_CS.
DR   PANTHER; PTHR18945; PTHR18945; 1.
DR   PANTHER; PTHR18945:SF33; PTHR18945:SF33; 1.
DR   Pfam; PF02931; Neur_chan_LBD; 1.
DR   Pfam; PF02932; Neur_chan_memb; 1.
DR   PRINTS; PR00253; GABAARECEPTR.
DR   PRINTS; PR01724; GABAARPI.
DR   PRINTS; PR00252; NRIONCHANNEL.
DR   SUPFAM; SSF63712; SSF63712; 1.
DR   SUPFAM; SSF90112; SSF90112; 1.
DR   TIGRFAMs; TIGR00860; LIC; 1.
DR   PROSITE; PS00236; NEUROTR_ION_CHANNEL; 1.
PE   3: Inferred from homology;
KW   Cell membrane {ECO:0000256|SAAS:SAAS00457684};
KW   Complete proteome {ECO:0000313|Proteomes:UP000008227};
KW   Disulfide bond {ECO:0000256|SAAS:SAAS00766067};
KW   Ion channel {ECO:0000256|RuleBase:RU000687,
KW   ECO:0000256|SAAS:SAAS00081334};
KW   Ion transport {ECO:0000256|RuleBase:RU000687,
KW   ECO:0000256|SAAS:SAAS00457623};
KW   Membrane {ECO:0000256|SAAS:SAAS00978300, ECO:0000256|SAM:Phobius};
KW   Receptor {ECO:0000313|EMBL:HCZ90067.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008227};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00978734,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00978768,
KW   ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU000687,
KW   ECO:0000256|SAAS:SAAS00457659}.
FT   SIGNAL        1     20       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        21    440       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5020133382.
FT   TRANSMEM    242    264       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    276    296       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    308    326       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    420    439       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       42    241       Neur_chan_LBD. {ECO:0000259|Pfam:
FT                                PF02931}.
FT   DOMAIN      249    339       Neur_chan_memb. {ECO:0000259|Pfam:
FT                                PF02932}.
SQ   SEQUENCE   440 AA;  50738 MW;  DD7485933A7C1B9B CRC64;
     MRQSLRWTFL CLTLFTGRMC IRENQFHVEA SRSDKLSLPG FENLTAGYNK FLRPNFGGEP
     VQIALTLDIA SISSISESNM DYTATIYLRQ RWTDQRLVFE GNKSFTLDAR LVEFLWVPDT
     YIVESKKSFL HEVTVGNRLI RLFSNGTVLY ALRITTTVAC NMDLSKYPMD TQTCKLQLES
     WGYDGNDVEF SWLRGNDSVR GLENLRLAQY TIQQYFTLVT RSQQETGNYT RLVLQFELQR
     NVLYFILETY VPSTFLVVLS WVSFWISLDS VPARTCIGVT TVLSMTTLMI GSRTSLPNTN
     CFIKAIDVYL GICFSFVFGA LLEYAVAHYS SLQQMAAKDR GKAKEVEEVN ITNIINSSIS
     SFKRKISFAS IEISGDNVDY SDLTMKTSDK FKFVFRDKMG RIVDYFTIQN PSNVDRYSKL
     LFPLVFMLAN VFYWAYYMYF
//
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