ID F1RW59_PIG Unreviewed; 622 AA.
AC F1RW59;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 3.
DT 27-MAR-2024, entry version 79.
DE SubName: Full=Zinc finger protein 182 {ECO:0000313|Ensembl:ENSSSCP00000013073.3};
GN Name=ZNF182 {ECO:0000313|Ensembl:ENSSSCP00000013073.3,
GN ECO:0000313|VGNC:VGNC:95199};
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00000013073.3, ECO:0000313|Proteomes:UP000008227};
RN [1] {ECO:0000313|Ensembl:ENSSSCP00000013073.3, ECO:0000313|Proteomes:UP000008227}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000013073.3,
RC ECO:0000313|Proteomes:UP000008227};
RG Porcine genome sequencing project;
RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSSCP00000013073.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_005657857.1; XM_005657800.2.
DR RefSeq; XP_013846336.1; XM_013990882.1.
DR RefSeq; XP_013846337.1; XM_013990883.1.
DR AlphaFoldDB; F1RW59; -.
DR SMR; F1RW59; -.
DR STRING; 9823.ENSSSCP00000013073; -.
DR PaxDb; 9823-ENSSSCP00000013073; -.
DR Ensembl; ENSSSCT00000013433.4; ENSSSCP00000013073.3; ENSSSCG00000012284.5.
DR GeneID; 100627428; -.
DR KEGG; ssc:100627428; -.
DR CTD; 7569; -.
DR VGNC; VGNC:95199; ZNF182.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000162614; -.
DR HOGENOM; CLU_002678_0_12_1; -.
DR InParanoid; F1RW59; -.
DR OrthoDB; 2997404at2759; -.
DR TreeFam; TF350805; -.
DR Proteomes; UP000008227; Chromosome X.
DR Bgee; ENSSSCG00000012284; Expressed in oocyte and 44 other cell types or tissues.
DR ExpressionAtlas; F1RW59; baseline.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd07765; KRAB_A-box; 1.
DR Gene3D; 6.10.140.140; -; 1.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 14.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR24393:SF15; IP01201P-RELATED; 1.
DR PANTHER; PTHR24393; ZINC FINGER PROTEIN; 1.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 14.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 14.
DR SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 8.
DR SUPFAM; SSF109640; KRAB domain (Kruppel-associated box); 1.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 14.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 14.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000008227};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00042}.
FT DOMAIN 8..79
FT /note="KRAB"
FT /evidence="ECO:0000259|PROSITE:PS50805"
FT DOMAIN 217..244
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 245..272
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 273..300
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 301..328
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 329..356
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 357..384
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 385..412
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 413..440
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 441..468
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 469..496
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 497..524
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 525..552
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 553..580
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 581..608
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT REGION 602..622
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 622 AA; 71649 MW; 5C0D862EF8B732E3 CRC64;
MAEPQGLMTF EDVAVDFTQE EWQYLNPLQR TLYRDVMLET YSNLVSVAGQ HVTKPTLILK
LEVEEPCLAE GKIPVWNFPE EACQVDEQIE RQHEDDQDKY LLQIGLPDKK TVITKSGHDY
NEFGSILHLS TNFVASIQIP YKHESFGHNM VDNLDLFNRS SVGKKHDNGC AKLFFHTEYE
KTTPGVKAYG YKDYGKTLRQ KKGLSLHQRI KNGEKPFECT ACRKTFSKKS HLIVHWRTHT
GEKPFGCTEC GKAFSQKSQL IIHLRTHTGE RPFECPECGK AFREKSTVII HYRTHTGEKP
YECNECGKAF TQKSNLIVHQ KTHTGEKTYE CTKCGESFIQ KLDLIIHHST HTGKKPHECN
ECKKTFSDKS TLIIHQRTHT GEKPHKCTEC GKSFNEKSTL IVHQRTHTGE KPYECDVCGK
TFTQKSNLGV HQRTHSGEKP FECNECEKAF SQKSYLMLHQ RGHTGEKPYE CNECEKAFSQ
KSYLIIHQRT HTEEKPYKCN ECGKAFREKS KLIIHQRIHT GEKPYECPVC WKAFSQKSQL
IIHQRTHTGE KPYACTECGK AFREKSTFTV HQRTHTGEKP YKCTECGKAF TQKSNLIVHQ
RTHTGKKAHG KGHTRKSKLI AH
//
