ID F1RWD4_PIG Unreviewed; 1060 AA.
AC F1RWD4;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 4.
DT 27-MAR-2024, entry version 72.
DE SubName: Full=Zinc finger E-box binding homeobox 1 {ECO:0000313|Ensembl:ENSSSCP00000011759.4};
GN Name=ZEB1 {ECO:0000313|Ensembl:ENSSSCP00000011759.4,
GN ECO:0000313|VGNC:VGNC:95536};
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00000011759.4, ECO:0000313|Proteomes:UP000008227};
RN [1] {ECO:0000313|Ensembl:ENSSSCP00000011759.4, ECO:0000313|Proteomes:UP000008227}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000011759.4,
RC ECO:0000313|Proteomes:UP000008227};
RG Porcine genome sequencing project;
RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSSCP00000011759.4}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the delta-EF1/ZFH-1 C2H2-type zinc-finger
CC family. {ECO:0000256|ARBA:ARBA00009867}.
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DR AlphaFoldDB; F1RWD4; -.
DR PaxDb; 9823-ENSSSCP00000023082; -.
DR Ensembl; ENSSSCT00000012067.5; ENSSSCP00000011759.4; ENSSSCG00000011025.6.
DR VGNC; VGNC:95536; ZEB1.
DR eggNOG; KOG3623; Eukaryota.
DR GeneTree; ENSGT00950000183208; -.
DR ChiTaRS; LOC100520325; pig.
DR Proteomes; UP000008227; Chromosome 10.
DR Bgee; ENSSSCG00000011025; Expressed in stomach and 42 other cell types or tissues.
DR ExpressionAtlas; F1RWD4; baseline and differential.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:UniProt.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:UniProt.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 6.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR InterPro; IPR008598; Di19_Zn-bd.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR24391; HISTONE H4 TRANSCRIPTION FACTOR-RELATED; 1.
DR PANTHER; PTHR24391:SF18; ZINC FINGER PROTEIN 1; 1.
DR Pfam; PF00096; zf-C2H2; 4.
DR Pfam; PF05605; zf-Di19; 1.
DR SMART; SM00389; HOX; 1.
DR SMART; SM00355; ZnF_C2H2; 7.
DR SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 4.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 5.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 6.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000008227};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00042}.
FT DOMAIN 103..131
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 133..160
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 173..200
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 837..864
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 865..892
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 893..921
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT REGION 1..58
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 76..96
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 236..260
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 421..465
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 487..522
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 569..647
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 790..831
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 923..1060
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 238..260
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 421..440
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 441..458
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 605..647
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 799..819
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 959..981
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 990..1015
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1043..1060
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1060 AA; 115974 MW; 4D7BD1BCF011C4FD CRC64;
MADGPRCKRR KQANPRRNNG KEGQEILGPE ARAEEVGCTV KDDECDSDAE NEQNHDPNVE
EFLQQQDTAV IYPEAPEEDQ RQGTPEASGH DENGTPDAFS QLLTCPYCDR GYKRFTSLKE
HIKYRHEKNE DNFSCSLCSY TFAYRTQLER HMTSHKSGRD QRHVTQSGGN RKFKCTECGK
AFKYKHHLKE HLRIHSGEKP YECPNCKKRF SHSGSYSSHI SSKKCISLMP VNGRPRAGLK
TSQCSSPSLS ASPGSPTRPQ IRQKLENKPL QEQLSVNQIK TEPVDYEFKP IVVASGINCS
TPLQNGVFSG GGPLQATNSP QGVVQAVVLP TVGLVSPISI NLSDIQNVLK VAVDGNVIRQ
VLENNQANLA SKEQETINAS SIQQGGHSVI SAISLPLVDQ DGTTKIIINY SLEQPSQLQV
VPQNLKKETP VPTNSCKSEK LPEDLTVKSE KDKSFEGGGR NDSTCLLCDD RPGDASALAE
LKHCDLRQPA QPPPLPAPEA DKPEASDPSG SGEGGLSPSR PPLKNLLSLL KAYYALNAQP
SAEELSKIAD SVNLPLDVVK KWFEKMQAGQ VSVQPSEPSS PEPGRANLPA KSDDQPPPPD
ADEPQDSTGH QQSPLKITSS PVLPVGSAVN GSRSSTPPSP LNLSSSRNTQ GYLYTAEGAA
EEPQVEPLDL SLPKQQGELL ERSTITSVYQ NSVYSVQEEP LNLSCAKKEP QKDSCGTDSE
PVVNVIPPSA NPINIAIPTV TAQLPTIVAI AGQNSVPCLR ALAANKQAVL IPQVAYTYST
AVSPAVQDAP LKVIPPNGNQ DERQDTSSEG VSNVEEQNDS DSTPPKKKMR KTENGMYACD
LCDKIFQKSS SLLRHKYEHT GKRPHECGIC KKAFKHKHHL IEHMRLHSGE KPYQCDKCGK
RFSHSGSYSQ HMNHRYSYCK REAEERDAGP EDAGPGAWPN EHAGARASPS QGDSDERESS
TREEDEDSDK EEEEEEREME ELQEEKGSGE PGGEEEEEEE EEEEMEEEEE QETEEQEEGG
RAKTAGATAE REGAGSPESS LEHKVSEGSE QVSEEKTNEA
//
