ID F1RWW1_PIG Unreviewed; 353 AA.
AC F1RWW1;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 2.
DT 27-MAR-2024, entry version 76.
DE SubName: Full=Atonal bHLH transcription factor 1 {ECO:0000313|Ensembl:ENSSSCP00000009805.2};
DE SubName: Full=Protein atonal homolog 1 {ECO:0000313|EMBL:HCZ81925.1};
GN Name=ATOH1 {ECO:0000313|Ensembl:ENSSSCP00000009805.2,
GN ECO:0000313|VGNC:VGNC:85631};
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00000009805.2, ECO:0000313|Proteomes:UP000008227};
RN [1] {ECO:0000313|Ensembl:ENSSSCP00000009805.2, ECO:0000313|Proteomes:UP000008227}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000009805.2,
RC ECO:0000313|Proteomes:UP000008227};
RG Porcine genome sequencing project;
RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:HCZ81925.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=30723633; DOI=.7717/peerj.6374;
RA Gilbert D.G.;
RT "Genes of the pig, Sus scrofa, reconstructed with EvidentialGene.";
RL PeerJ 7:E6374-E6374(2019).
RN [3] {ECO:0000313|Ensembl:ENSSSCP00000009805.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; DQIR01026450; HCZ81925.1; -; Transcribed_RNA.
DR STRING; 9823.ENSSSCP00000009805; -.
DR PaxDb; 9823-ENSSSCP00000009805; -.
DR Ensembl; ENSSSCT00000010069.3; ENSSSCP00000009805.2; ENSSSCG00000009196.3.
DR VGNC; VGNC:85631; ATOH1.
DR eggNOG; KOG4395; Eukaryota.
DR GeneTree; ENSGT00940000160064; -.
DR HOGENOM; CLU_083039_0_0_1; -.
DR OMA; CKNDHHH; -.
DR OrthoDB; 5406645at2759; -.
DR TreeFam; TF315153; -.
DR Proteomes; UP000008227; Chromosome 8.
DR Bgee; ENSSSCG00000009196; Expressed in duodenum and 5 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0031490; F:chromatin DNA binding; IEA:Ensembl.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IEA:Ensembl.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IBA:GO_Central.
DR GO; GO:0070888; F:E-box binding; IBA:GO_Central.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0042668; P:auditory receptor cell fate determination; IEA:Ensembl.
DR GO; GO:0042667; P:auditory receptor cell fate specification; IEA:Ensembl.
DR GO; GO:0061564; P:axon development; IBA:GO_Central.
DR GO; GO:0007411; P:axon guidance; IEA:Ensembl.
DR GO; GO:0021987; P:cerebral cortex development; IEA:Ensembl.
DR GO; GO:1904019; P:epithelial cell apoptotic process; IEA:Ensembl.
DR GO; GO:0042472; P:inner ear morphogenesis; IEA:Ensembl.
DR GO; GO:1904036; P:negative regulation of epithelial cell apoptotic process; IEA:Ensembl.
DR GO; GO:0014014; P:negative regulation of gliogenesis; IEA:Ensembl.
DR GO; GO:0097402; P:neuroblast migration; IEA:Ensembl.
DR GO; GO:0048663; P:neuron fate commitment; IBA:GO_Central.
DR GO; GO:0001764; P:neuron migration; IEA:Ensembl.
DR GO; GO:0007219; P:Notch signaling pathway; IEA:Ensembl.
DR GO; GO:0045609; P:positive regulation of inner ear auditory receptor cell differentiation; IEA:Ensembl.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0007423; P:sensory organ development; IBA:GO_Central.
DR GO; GO:0006366; P:transcription by RNA polymerase II; IEA:Ensembl.
DR CDD; cd19713; bHLH_TS_ATOH1; 1.
DR Gene3D; 4.10.280.10; Helix-loop-helix DNA-binding domain; 1.
DR InterPro; IPR032661; ATOH1_bHLH.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR PANTHER; PTHR19290; BASIC HELIX-LOOP-HELIX PROTEIN NEUROGENIN-RELATED; 1.
DR PANTHER; PTHR19290:SF82; TRANSCRIPTION FACTOR ATOH1; 1.
DR Pfam; PF00010; HLH; 1.
DR SMART; SM00353; HLH; 1.
DR SUPFAM; SSF47459; HLH, helix-loop-helix DNA-binding domain; 1.
DR PROSITE; PS50888; BHLH; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000008227}.
FT DOMAIN 158..210
FT /note="BHLH"
FT /evidence="ECO:0000259|PROSITE:PS50888"
FT REGION 9..41
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 91..120
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 215..276
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 310..353
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 9..25
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 215..229
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 244..260
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 310..327
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 328..353
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 353 AA; 38172 MW; D8C860029A1A6611 CRC64;
MSRLLHAEEW AEVKELGDHH RHPQPHHLPQ PPPPQPPATL QTREHHVYPA ELSLLDSTDP
RAWLAPTLQG ICTARAAQYL LHSPELGASE AAAPRDEADG RGELVRRSGG VGGSSKSPGP
VKVREQLCKL KGGVVVDELV CSRQRAPSSK QVNGVQKQRR LAANARERRR MHGLNHAFDQ
LRNVIPSFNN DKKLSKYETL QMAQIYINAL SELLQTPSGG DQPPQQPASC KSDHHHLRAS
APYEASAGTT TATGTPPASG GGQRPTPPGS CRTRFSVPTS AGGYSVQLEA LHFSTFDDSA
LTAMMAQKNL SPSLPGGILQ PVQEESSKTS PRSHRSDGEF SPHSHYSDSD EAS
//
