ID F1RYK6_PIG Unreviewed; 2353 AA.
AC F1RYK6;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 4.
DT 27-MAR-2024, entry version 73.
DE SubName: Full=Otogelin like {ECO:0000313|Ensembl:ENSSSCP00000001010.4};
GN Name=OTOGL {ECO:0000313|Ensembl:ENSSSCP00000001010.4,
GN ECO:0000313|VGNC:VGNC:91091};
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00000001010.4, ECO:0000313|Proteomes:UP000008227};
RN [1] {ECO:0000313|Ensembl:ENSSSCP00000001010.4, ECO:0000313|Proteomes:UP000008227}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000001010.4,
RC ECO:0000313|Proteomes:UP000008227};
RG Porcine genome sequencing project;
RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSSCP00000001010.4}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00039}.
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DR SMR; F1RYK6; -.
DR STRING; 9823.ENSSSCP00000001010; -.
DR PaxDb; 9823-ENSSSCP00000001010; -.
DR Ensembl; ENSSSCT00000001032.4; ENSSSCP00000001010.4; ENSSSCG00000000943.4.
DR VGNC; VGNC:91091; OTOGL.
DR eggNOG; KOG1216; Eukaryota.
DR GeneTree; ENSGT00940000160698; -.
DR HOGENOM; CLU_000076_0_0_1; -.
DR InParanoid; F1RYK6; -.
DR TreeFam; TF330609; -.
DR Proteomes; UP000008227; Chromosome 5.
DR Bgee; ENSSSCG00000000943; Expressed in pituitary gland and 9 other cell types or tissues.
DR ExpressionAtlas; F1RYK6; baseline.
DR GO; GO:0031012; C:extracellular matrix; IBA:GO_Central.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0046556; F:alpha-L-arabinofuranosidase activity; IEA:InterPro.
DR GO; GO:0046373; P:L-arabinose metabolic process; IEA:InterPro.
DR CDD; cd19941; TIL; 4.
DR Gene3D; 2.80.10.50; -; 1.
DR Gene3D; 2.10.25.10; Laminin; 5.
DR InterPro; IPR036195; AbfB_ABD_sf.
DR InterPro; IPR006207; Cys_knot_C.
DR InterPro; IPR036084; Ser_inhib-like_sf.
DR InterPro; IPR002919; TIL_dom.
DR InterPro; IPR014853; VWF/SSPO/ZAN-like_Cys-rich_dom.
DR InterPro; IPR001007; VWF_dom.
DR InterPro; IPR001846; VWF_type-D.
DR PANTHER; PTHR11339; EXTRACELLULAR MATRIX GLYCOPROTEIN RELATED; 1.
DR PANTHER; PTHR11339:SF225; OTOGELIN-LIKE PROTEIN; 1.
DR Pfam; PF08742; C8; 4.
DR Pfam; PF01826; TIL; 1.
DR Pfam; PF00094; VWD; 4.
DR SMART; SM00832; C8; 4.
DR SMART; SM00041; CT; 1.
DR SMART; SM00215; VWC_out; 2.
DR SMART; SM00216; VWD; 4.
DR SUPFAM; SSF110221; AbfB domain; 1.
DR SUPFAM; SSF57567; Serine protease inhibitors; 4.
DR PROSITE; PS01225; CTCK_2; 1.
DR PROSITE; PS51233; VWFD; 4.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00039}; Reference proteome {ECO:0000313|Proteomes:UP000008227};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..30
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 31..2353
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5023926136"
FT DOMAIN 121..297
FT /note="VWFD"
FT /evidence="ECO:0000259|PROSITE:PS51233"
FT DOMAIN 481..654
FT /note="VWFD"
FT /evidence="ECO:0000259|PROSITE:PS51233"
FT DOMAIN 946..1115
FT /note="VWFD"
FT /evidence="ECO:0000259|PROSITE:PS51233"
FT DOMAIN 1534..1724
FT /note="VWFD"
FT /evidence="ECO:0000259|PROSITE:PS51233"
FT DOMAIN 2261..2353
FT /note="CTCK"
FT /evidence="ECO:0000259|PROSITE:PS01225"
FT DISULFID 2282..2331
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00039"
SQ SEQUENCE 2353 AA; 263533 MW; 4E2F51B1BDE0D2E9 CRC64;
MNIVRKVNLM IPWSICWVHI LLFSLQGSIC SSSVLTRTSK NGFHENPQKR ALLAAQIEAT
SPRYFFHEAF NWGESKIKGS CPHECLNGAF CSKAGTCDCQ IFQALGTRCQ IVPNMGSGRD
GVCKTWGQYH FETFDGIYYY FPGNCSYIFA KDCGNLEPQY TVWVHNSPKC LGSVYYCYRS
ISLFFSDQEE IQIYGHEIKK NGISLTLPQT IGQVFIEKLA DYILVKTTFG VSLAWDGISG
IYLKLSEEHR GKSCGLCANY NGLQSDDFIV QQEDYTEDIA MFANSWLVQT ADDTKCIPTP
SDFPNPCSSG IPAFEAIFFK CQILLQFPFL SCHEYIDPYL YIASCVNDLC KTHDDDTYCR
AATEYARACS HAGYPIQDWR DDFPACIDKC DDSFVHRDCI SCCPPTCTFE KQCLGSNLRC
LDGCYCPDGL VMENGTCISL ENCPCNFHGL AYSVGSKIEQ ECTECVCVGG VWNCTEHDCP
VQCSVVGDSH FTTFDGRHYS FIGMCQYILV KGTGKDKFTI TLQKAHCEQN LGLVCLQSIT
LILEDDFNKQ VTLSRGGQIL TSPKQGFHLN GIVEIQTLSS LFILLKTTFG LKILFAVDGE
RIYIQLTSAW KRRTLGLCGT FNGNIRDDFL SPAGMIEGTP QLHANAWRVS STCFAPVHVP
VVDPCNINQQ NIGYAAHCDA IHQELFAPCH IYISPGLYYQ LCRHDACKCG SPCLCNALAH
YAYLCGQRGV PINFRAQVSF CGVVCQKGML YHHCASFCRR SCVSLSSLEQ CPEDCAEGCS
CPEGKYYEDT LSFCVPISHC RCHYRGSVYQ PGELIPTPSG LCQCSNGTVK CDELATPSTV
HVCPEGKQYF DCRFPDPELP AGGVNCETTC ANLAMNFTCA PSSPCISGCV CAPGMAEHKG
KCYVPESCPC VWKDWERLAG EAVATPCYTC VCRRGMFNCT YYPCPAVCTV YGDRHYHSFD
GLEYDYISDC QVFLIKSTDD SDISVIAQNK KCFDNDIVCS KSVLISVGDT EIYLNDTPYK
QKRSGFFLEN KPTYQLWKAG LYMVVYFPEK DITILWDKKT TIHIKVGPQW KSKLSGLCGN
FDKCTSNDMT TSNNLEVRNA QVFGDSWALG QCEAPSEPLK PCEAHQNKFP YAKKECSILY
SDVFAPCRNV IDVTSFAKNC HEDTCNCNLG GDCECLCTSV AAYAHKCCQE GVPVRWRSSS
VCSLDCEYYN EGLGEGPYML ASYGHSGFIL GANMTSGSIF SLSRSSIHGN LFFNFMITPG
LFKEKASTLV LVSLESAERP NYFFFVQDDD SLRLKLWEAS SAFHRRATFF HHQGLWIPSY
SAFELYSKKG FFIILTDSSA RASKYDDSEE FKHLSSFRIE ETQAAVPYRR MCEWRYEPCA
TPCFKTCSDP EALACKFLPP VEGCLPYCPK NMILDEVTLK CVYPEDCIPL MPTEPALISP
GEPSLPGFTG PEMVTPSVFT VFDMLTPTTG LECEPQKFDP VYNCSQYICL NMEWKLYNWS
LHCPKGLETP DCGFRGRPVQ VNRDVCCPEW ECPCRCSMLS ELSIVTFDGN NAALYSMASY
ILVRVPGEVI VAHIEKCSMN QNGNSFKKLA SSGRISGLCF KKLNLTTSLH EILVNRAERK
VHVDSAAVPL PFAKQDLSIE DSGSMYVIAT PAGLMVKWAH LTGIVDIHFG SQFNLSSHTE
GLCGICNEDP DDDLRMQNGT IITNMEDIEL FIESWEIEKS FKVTTRRPVR NCTEHDCSHC
IELLNRKAFI PCHDKVSPQD FCEKMWINYT YFWNYECDAL SAYVALCNKF DVCIRWRTPD
YCPLSCPEGK EYQPCVQPCE ARTCLNRWFY GYSSCLKLRE DCVCKNGTIL HRPDSTRCIP
EKECACTDSE DRPRTAGEVW NGGIDECALY RCLENSSIIP IEPDCDEAPS PVCEREAQVV
LSFVDKWTCC SKEVCSCDMT LCETAIPTCT DSQKLIIGHS PFSCCPQYLC ECDPSKCPVI
SIPECREDQF MIQVQQEEPC CFSPLCVCKP CTQPIPLCAD GEFLTLDLNT THVCCPQYYC
VCEPNLCPMP LLNCAEDMKL VKENVSGQCC PTWHCECSCE NLVMPTCKVG EFAAVDRSFQ
SDCGCVQYLC EKDDVCVFQE VSVLNPGQSM IKYLEGDFCY TAECLEEKDN HTGFHTLNIT
VVNCSKECDV HQVYTPSPSD YDCCGTCKNV SCKFQMDNGT LVVYEEGSTW HYNCTTFECV
KTDEGAMILN YSVVCPPFNE TECKMNEGVI KLYNEGCCKI CKREERLCQK VIIKSVIRKQ
DCVSQSSINV ASCEGKCPSA TIYNINVESH LRFCKCCREN GVRNLTVPLY CSGNGTQVLH
TLQEPIDCTC QWS
//
