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Database: UniProt
Entry: F1RZR0_PIG
LinkDB: F1RZR0_PIG
Original site: F1RZR0_PIG 
ID   F1RZR0_PIG              Unreviewed;      2670 AA.
AC   F1RZR0;
DT   03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 2.
DT   16-JAN-2019, entry version 61.
DE   SubName: Full=Inositol 1,4,5-trisphosphate receptor type 3 {ECO:0000313|Ensembl:ENSSSCP00000001647};
GN   Name=ITPR3 {ECO:0000313|Ensembl:ENSSSCP00000001647};
OS   Sus scrofa (Pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Suina; Suidae;
OC   Sus.
OX   NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00000001647, ECO:0000313|Proteomes:UP000008227};
RN   [1] {ECO:0000313|Ensembl:ENSSSCP00000001647, ECO:0000313|Proteomes:UP000008227}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000001647};
RG   Porcine genome sequencing project;
RL   Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSSSCP00000001647}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (MAY-2011) to UniProtKB.
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DR   EMBL; AEMK02000055; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_013833248.1; XM_013977794.1.
DR   UniGene; Ssc.12677; -.
DR   STRING; 9823.ENSSSCP00000001647; -.
DR   PaxDb; F1RZR0; -.
DR   PeptideAtlas; F1RZR0; -.
DR   PRIDE; F1RZR0; -.
DR   Ensembl; ENSSSCT00000001691; ENSSSCP00000001647; ENSSSCG00000001518.
DR   GeneID; 100155015; -.
DR   CTD; 3710; -.
DR   eggNOG; KOG3533; Eukaryota.
DR   eggNOG; ENOG410XR97; LUCA.
DR   GeneTree; ENSGT00940000157078; -.
DR   InParanoid; F1RZR0; -.
DR   OrthoDB; 94996at2759; -.
DR   TreeFam; TF312815; -.
DR   Reactome; R-SSC-114508; Effects of PIP2 hydrolysis.
DR   Reactome; R-SSC-139853; Elevation of cytosolic Ca2+ levels.
DR   Reactome; R-SSC-381676; Glucagon-like Peptide-1 (GLP1) regulates insulin secretion.
DR   Reactome; R-SSC-5578775; Ion homeostasis.
DR   Reactome; R-SSC-983695; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers.
DR   Proteomes; UP000008227; Chromosome 7.
DR   Bgee; ENSSSCG00000001518; Expressed in 6 organ(s), highest expression level in liver.
DR   ExpressionAtlas; F1RZR0; baseline and differential.
DR   Genevisible; F1RZR0; SS.
DR   GO; GO:0030659; C:cytoplasmic vesicle membrane; IBA:GO_Central.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IBA:GO_Central.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0016529; C:sarcoplasmic reticulum; IBA:GO_Central.
DR   GO; GO:0030667; C:secretory granule membrane; IBA:GO_Central.
DR   GO; GO:0005509; F:calcium ion binding; IBA:GO_Central.
DR   GO; GO:0070679; F:inositol 1,4,5 trisphosphate binding; IBA:GO_Central.
DR   GO; GO:0005220; F:inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity; IBA:GO_Central.
DR   GO; GO:0035091; F:phosphatidylinositol binding; IBA:GO_Central.
DR   GO; GO:0051209; P:release of sequestered calcium ion into cytosol; IBA:GO_Central.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR000493; InsP3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   PRINTS; PR00779; INSP3RECEPTR.
DR   SMART; SM00472; MIR; 4.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000008227};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008227};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2200   2225       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2237   2255       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2267   2287       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2323   2348       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2368   2390       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2497   2520       Helical. {ECO:0000256|SAM:Phobius}.
FT   COILED       90    110       {ECO:0000256|SAM:Coils}.
FT   COILED     2628   2655       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2670 AA;  303747 MW;  41C206E34D805EB5 CRC64;
     MSEMSSFLHI GDIVSLYAEG SVNGFISTLG LVDDRCVVEP AAGDLDNPPK KFRDCLFKVC
     PMNRYSAQKQ YWKAKQTKQD KEKIADVVLL QKLQHAAQME QKQNDTENKK VHGDVVKYGS
     VIQLLHMKSN KYLTVNKRLP ALLEKNAMRV TLDATGNEGS WLFIQPFWKL RSNGDNVVVG
     DKVILNPVNA GQPLHASNYE LSDNAGCKEV NSVNCNTSWK INLFMQFRDH LEEVLKGGDV
     VRLFHAEQEK FLTCDEYRGK LQVFLRTTLR QSATSATSSN ALWEVEVVHH DPCRGGAGHW
     NGLYRFKHLA TGNYLAAEEN PSYKGDASDA KAAGTGAQGR TGRRNAGEKI KYRLVAVPHG
     NDIASLFELD PTTLQKTDSF VPRNSYVRLR HLCTNTWIQS TNVPIDVEEE RPIRLMLGTC
     PTKEDKEAFA IVSVPVSEIR DLDFANDASS MLASAVEKLN EGFISQNDRR FVIQLLEDLV
     FFVSDVPNNG QNVLDIMVTK PNRERQKLMR EQNILKQIFG ILKAPFRDKG GEGPLVRLEE
     LSDQKNAPYQ HMFRLCYRVL RHSQEDYRKN QEHIAKQFGM MQSQIGYDIL AEDTITALLH
     NNRKLLEKHI TKTEVETFVS LVRKNREPRF LDYLSDLCVS NHVAIPVTQE LICKCVLDPK
     NSDILIQTEL RPVKEMAQSH EYLSIEYSEE EVWLTWTDKN NEHHEKSVRQ LAQEARAGNA
     HDENVLSYYR YQLKLFARMC LDRQYLAIDE ISQQLGVDLI FLCMADEMLP FDLRASFCHL
     MLHVHVDRDP QELVTPVKFA RLWTEIPTAI TIKDYDSNLN ASRDDKKNKF ASTMEFVEDY
     LNNVVSEAVP FANEEKNKLT FEVVSLAHNL IYFGFYSFSE LLRLTRTLLG IIDCVQGPPA
     MLQAYEDSGK NVRRSIQGVG HMMSTMVLNR KQSVFGGPSL PAGAGAPEAL DRSKFEENED
     IVVMETKLKI LEILQFILNV RLDYRISYLL SVFKKEFVEV FPMQDSGADG TAPAFDSTTA
     NMNLDRIGEQ AEAMFGVGKT SSMLEVDDEG GRAFLRVLIH LTMHDYAPLV SGALQLLFKH
     FSQRQEAMHT FKQVQLLISA QDVENYKVIK SELDRLRTMV EKSELWVDKK GSGKGEEVEA
     GAAKDKKERP TDEEGFLQPP GERSSENYQI VKGILERLNK MCGVGEQMRK KQQRLLKNMD
     AHKVMLDLLQ IPYDKGDAKM MEILRYTHQF LQKFCAGNPG NQALLHKHLH LFLTPGLLEA
     ETMQHIFLNN YQLCSEIGEP VLQHFVHLLA THGRHVQYLD FLHTVIKAEG KYVKKCQDMI
     MTELTNAGDD VVVFYNDKAS LAHLLDMMKA ARDGVEDHSP LMYHISLVDL LAACAEGKNV
     YTEIKCTSLL PLEDVVSVVT HEDCITEVKM AYVNFVNHCY VDTEVEMKEI YTSNHIWTLF
     ESFTLDMARV CSKREKRLAD PTLEKYVLTV VLDTINAFFS SPFSENSTSL QTHQTIVVQL
     LQSTTRLLEC PWLQQQHKGS VEACIRTLAM VAKGRAILLP MDLDAHISSL LSSGASCAAA
     AQRSASSYKA ATRAFPRVTP TANQWDYKNI IEKLQDIITA LEERLKPLVQ AELSVLVDVL
     HWPELLFLEG SEAYQRCESG GFLSKLIQHT KDLMESEEKL CVKVLRTLQQ MLLKKTKYGD
     RGNQLRKMLL QNYLQNRKSS TRGDLPDPMG TGLDQDWSVI AATQCRLDKE GATKLVCDLI
     TSTKNEKIFQ ESIGLAIRLL DGGNTEIQKS FYNLMTSDKK SERFFKVLHD RMKRAQQETK
     STVAVNMSEL GSQPREDREP ADPAAKGRVA SFSVPGSSSR YSLGPSLRRG HEVGERVQSN
     EMGSSVLIMQ PILRFLQLLC ENHNRDLQNF LRCQNNKTNY NLVCETLQFL DIMCGSTTGG
     LGLLGLYINE DNVGLVIQTL ETLTEYCQGP CHENQTCIVT HESNGIDIIT ALILNDISPL
     CKYRMDLVLQ LKDNASKLLL ALMESRHDSE NAERILISLR PQELVDVIKK AYLQEEEREN
     SDVSPREVGH NIYILALQLS RHNKQLQHLL KPVKRIQEEE AEGISSMLSL NNKQLSQMLK
     PSAPAQEEEE DPLAYYENHT SQIEIVRQDR SMEQIVFPVP AICQFLTEET KHRLFTTTEQ
     DEQGSKVSDF FDQSSFLHNE MEWQRKLRSM PLIYWFSRRM TLWGSISFNL AVFINIIIAF
     FYPYVEGAST GVLGSPLISL LFWILICFSI AALFTKRYSV RPLIVALILR SIYYLGIGPT
     LNILGALNLT NKIVFVVSFV GNRGTFIRGY KAMVMDVEFL YHVGYILTSV LGLFAHELFY
     SILLFDLIYR EETLFNVIKS VTRNGRSILL TALLALILVY LFSIVGFLFL KDDFILEVDR
     LPGNHSRASP LGMPHGAATF VDTCSGNNMD CVSRVSVPQV LEEDEEQAST ERACDTLLMC
     IVTVMNHGLR NGGGVGDILR KPSKDESLFP ARVVYDLLFF FIVIIIVLNL IFGVIIDTFA
     DLRSEKQKKE EVLKTTCFIC GLERDKFDNK TVSFEEHIKF EHNMWNYLYF IVLVRVKNKT
     DYTGPESYVA QMIKNKNLDW FPRMRAMSLV SNEGEGEQNE IRILQDKLNS TMKLVSHLTT
     QLNELKEQMT EQRKRRQRLG FVDVQNCMSR
//
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