ID F1S0H3_PIG Unreviewed; 452 AA.
AC F1S0H3;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 3.
DT 27-MAR-2024, entry version 79.
DE RecName: Full=Rho GTPase-activating protein 15 {ECO:0000256|ARBA:ARBA00040777};
DE AltName: Full=ArhGAP15 {ECO:0000256|ARBA:ARBA00042482};
DE AltName: Full=Rho-type GTPase-activating protein 15 {ECO:0000256|ARBA:ARBA00042925};
GN Name=ARHGAP15 {ECO:0000313|Ensembl:ENSSSCP00000016615.3,
GN ECO:0000313|VGNC:VGNC:95959};
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00000016615.3, ECO:0000313|Proteomes:UP000008227};
RN [1] {ECO:0000313|Ensembl:ENSSSCP00000016615.3, ECO:0000313|Proteomes:UP000008227}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000016615.3,
RC ECO:0000313|Proteomes:UP000008227};
RG Porcine genome sequencing project;
RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSSCP00000016615.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Membrane {ECO:0000256|ARBA:ARBA00004170}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004170}.
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DR AlphaFoldDB; F1S0H3; -.
DR Ensembl; ENSSSCT00000017070.5; ENSSSCP00000016615.3; ENSSSCG00000015671.5.
DR VGNC; VGNC:95959; ARHGAP15.
DR GeneTree; ENSGT00950000182860; -.
DR HOGENOM; CLU_015883_1_0_1; -.
DR OMA; DHNQWED; -.
DR Proteomes; UP000008227; Chromosome 15.
DR Bgee; ENSSSCG00000015671; Expressed in blood and 38 other cell types or tissues.
DR ExpressionAtlas; F1S0H3; baseline and differential.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd13233; PH_ARHGAP9-like; 1.
DR CDD; cd04403; RhoGAP_ARHGAP27_15_12_9; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR PANTHER; PTHR23176:SF108; RHO GTPASE-ACTIVATING PROTEIN 15; 1.
DR PANTHER; PTHR23176; RHO/RAC/CDC GTPASE-ACTIVATING PROTEIN; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 4: Predicted;
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Reference proteome {ECO:0000313|Proteomes:UP000008227}.
FT DOMAIN 56..166
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 258..447
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 452 AA; 51907 MW; 7913DB9814B4BCE0 CRC64;
MQKSTNSDTS VETLNPTRQA TGAVQMRIKN ANSHHDRLSQ SKSMILTDVG KVTEPMVEKE
GYLQKAKIAD GGKKLRKNWS TSWVVLSSRK IEFYKESKQQ ALSNMKTGHK PENIDLCGAQ
IEWAKEKSSR KNVFQITTVS GNEFLLQSDI DFIILDWFHA IKNAIDRLPK DPSTPSRNLE
LFKIQRSSST ELLSHYDSDI KEQKPEHRKS LMFRLHHSAS DTSDKNRVKS RLKKFITRRP
SLKTLQEKGL IKDQIFGSHL HTVCERENST VPRFVKQCIE AVEKRGLNVD GIYRVSGNLA
TIQKLRFIVN QEEKLNLDDS QWEDIHVVTG ALKMFFRELP EPLFPYSFFE RFVEAIKKQD
NNTRIETVKS LVQKLPPPNR DTMKVLFRHL TKIVAKASKN LMSTQSLGIV FGPTLLRAEN
EAGNMAVHMV YQNQIVELML SEYSKIFGLE ED
//
