ID F1S0H8_PIG Unreviewed; 1732 AA.
AC F1S0H8;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 4.
DT 27-MAR-2024, entry version 71.
DE SubName: Full=Methyl-CpG binding domain protein 5 {ECO:0000313|Ensembl:ENSSSCP00000016610.4};
GN Name=MBD5 {ECO:0000313|Ensembl:ENSSSCP00000016610.4,
GN ECO:0000313|VGNC:VGNC:95940};
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00000016610.4, ECO:0000313|Proteomes:UP000008227};
RN [1] {ECO:0000313|Ensembl:ENSSSCP00000016610.4, ECO:0000313|Proteomes:UP000008227}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000016610.4,
RC ECO:0000313|Proteomes:UP000008227};
RG Porcine genome sequencing project;
RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSSCP00000016610.4}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR STRING; 9823.ENSSSCP00000016610; -.
DR PaxDb; 9823-ENSSSCP00000016610; -.
DR Ensembl; ENSSSCT00000017065.5; ENSSSCP00000016610.4; ENSSSCG00000015667.5.
DR VGNC; VGNC:95940; MBD5.
DR eggNOG; ENOG502QTC7; Eukaryota.
DR GeneTree; ENSGT00530000064137; -.
DR HOGENOM; CLU_009956_0_0_1; -.
DR InParanoid; F1S0H8; -.
DR TreeFam; TF106391; -.
DR Reactome; R-SSC-5689603; UCH proteinases.
DR Proteomes; UP000008227; Chromosome 15.
DR Bgee; ENSSSCG00000015667; Expressed in pituitary gland and 45 other cell types or tissues.
DR ExpressionAtlas; F1S0H8; baseline and differential.
DR GO; GO:0010369; C:chromocenter; IBA:GO_Central.
DR GO; GO:0030496; C:midbody; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0003682; F:chromatin binding; IBA:GO_Central.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR CDD; cd20141; PWWP_MBD5; 1.
DR Gene3D; 2.30.30.140; -; 1.
DR InterPro; IPR016177; DNA-bd_dom_sf.
DR InterPro; IPR001739; Methyl_CpG_DNA-bd.
DR InterPro; IPR000313; PWWP_dom.
DR PANTHER; PTHR16112; METHYL-CPG BINDING PROTEIN, DROSOPHILA; 1.
DR PANTHER; PTHR16112:SF18; METHYL-CPG-BINDING DOMAIN PROTEIN 5; 1.
DR SMART; SM00391; MBD; 1.
DR SUPFAM; SSF54171; DNA-binding domain; 1.
DR SUPFAM; SSF63748; Tudor/PWWP/MBT; 1.
DR PROSITE; PS50982; MBD; 1.
DR PROSITE; PS50812; PWWP; 1.
PE 4: Predicted;
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000008227}.
FT DOMAIN 11..81
FT /note="MBD"
FT /evidence="ECO:0000259|PROSITE:PS50982"
FT DOMAIN 1623..1647
FT /note="PWWP"
FT /evidence="ECO:0000259|PROSITE:PS50812"
FT REGION 123..160
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 200..274
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 329..350
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 451..520
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 594..642
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 671..692
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1028..1052
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1583..1613
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1706..1732
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 126..140
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 222..236
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 256..271
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 330..346
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 455..471
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 497..512
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 594..634
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1732 AA; 184105 MW; 81CE39DC3ADA5198 CRC64;
MNGGKECDGG DKDGGLPAIQ VPVGWQRRVD QNGVLYVSPS GSLLSCLEQV KTYLLTDGTC
KCGLECPLIL PKVFNFDPGA AVKQRTAEDV KADEDVTKLC IHKRKIIAVA TLHKSMEAPH
PSLVLTSPGG GTNATPVVPS RAATPRSARN KSHEGITNSV MPECKNPFKL MIGSSNAMGR
LYVQELPGSQ QQELHPVYPR QRLGSSEHGQ KSPFRGSHGG LPSPASSGSQ IYGDGSISPR
TDPLGSPDVF TRSNPGFHGA PNSSPIHLNR TPLSPPSVML HGSPIQSSCA MAGRTNIPLS
PTLTTKSPVM KKPMCNFSTN MEIPRAMFHH KPPQGPPPPP PPSCALQKKP LTSEKDPLGI
LDPIPSKPMN QNPVIINPTS FHSNVHSQVP VMNVSMPPAV VPLPSNLPLP TVKPGHMNHG
SHVQRVQHSA STSLSPSPVT SPVHMMGTGI GRIEASPQRS RSSSTSSDHG NFMMPPLGPQ
ATCSGIKVPP RSPRSTIGSP RPSMPSSPST KSDGHHQYKD IPNPLIAGMS NVLNTPSSAA
FPTASAGSGS VKSQPGLLGM PLNQILNQHN AASFPASSLL SAAAKAQLAN QNKLAGNNSS
SSSNSGAVAG SGNTEGHSTL NTMFPPTANM LLPTGEGQSG RAALRDKLMS QQKDSLRKRK
QPPTTVLSLL RQSQMDSSAV PKPGPDLLRK QGQGSFPISS MSQLLQSMSC QSSHLSSNST
PGCGGSNTAL PCSANQLHFT DPSMNSTVLQ NSLTQNIPLR GEAVHCHNAN TNFVHSNSPV
PNHHLAGLIN QIQASGNCGM LSQSGMALGN SLHPNPPQSR ISTSSTPVIP NSIVSSYNQT
SSEAGCSGPS SSIAIAGTNH PAITKTTSVL QDGVIVTTAA GNPLQSQLPI GSDFPFVGQE
HALHFPSNST SNNHLPHPLN PSLLSSLPIS LPVNQQHLLN QNLLNILQPS AGEGKSEINL
HPLGFLNPNV NAALAFLSSD MDGQVLQPVH FQLLAALLQN QAHAAAMLPL PSFNLTISDL
LQQQNTPLPS LTQMTAPPDH LPSNQSENSQ AETLLTSPLG NPLPSFAGSD TTFNPLLLPA
VTGASGLMTL NPQLLGGVLN SASANTANHP EVSIATSSQA TTTTTTTSSA VAALTVSTLG
GTAVVSMAET LLNVSNNAGN TSGPAKLNSN SVVPQLLNPL LGTGLLGDMS SINNTLNNHQ
LTHLQSLLNN NQMFPPNQQQ QQLLQGYQNL QAFQGQSTIP CPANNNPMAC LFQNFQVRMQ
EDAALLNKRI STQPGLTALP ENPNTTLPPF QDTSCELQSR IDPSLSQQVK DGLVVGGQGD
ASVDAIYKAV VDAASKGMQV VITTAVNSTT QISPIPALSA MSAFTASIGD PLSLPSAVSA
VIHGRNMSSV DHDGRLRNAR GARLPSNLDH GKNSNEGDGF EYFKSASCHT SKKQWDGEQS
PGGERNRWKC EEFLDHPGHI HNSPCHERPN NVSTLPFLPG EQHPILLPPR NCQGDKILEE
NFRYNNYKRT MMSFKERLEN TVERCAHING NRPRQSRGFG ELLSTTKQDL VLEEQSPSSS
NSLESSLVKD YIHYNGDFNA KSINGCVPSP SDAKSISSED DLRNPDSPSS NELIHYRPRT
FNVGDLVWGQ IKGLTSWPGK LVREDDVHSS CQQSPEEGKV EPEKLKTLTE GLEAYSRARK
RNRKSGKLNN HLEAAIHEAM SELDKMSGTV HQIPQGDRQM RPPKPKRRKI SR
//
