ID F1S1H2_PIG Unreviewed; 485 AA.
AC F1S1H2;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 4.
DT 27-MAR-2024, entry version 80.
DE SubName: Full=ETS variant transcription factor 4 {ECO:0000313|Ensembl:ENSSSCP00000018413.4};
GN Name=ETV4 {ECO:0000313|Ensembl:ENSSSCP00000018413.4,
GN ECO:0000313|VGNC:VGNC:87813};
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00000018413.4, ECO:0000313|Proteomes:UP000008227};
RN [1] {ECO:0000313|Ensembl:ENSSSCP00000018413.4, ECO:0000313|Proteomes:UP000008227}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000018413.4,
RC ECO:0000313|Proteomes:UP000008227};
RG Porcine genome sequencing project;
RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSSCP00000018413.4}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU004019}.
CC -!- SIMILARITY: Belongs to the ETS family. {ECO:0000256|ARBA:ARBA00005562,
CC ECO:0000256|RuleBase:RU004019}.
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DR RefSeq; XP_005668840.1; XM_005668783.2.
DR RefSeq; XP_005668841.1; XM_005668784.2.
DR RefSeq; XP_013836382.1; XM_013980928.1.
DR RefSeq; XP_013836383.1; XM_013980929.1.
DR AlphaFoldDB; F1S1H2; -.
DR SMR; F1S1H2; -.
DR STRING; 9823.ENSSSCP00000018413; -.
DR PaxDb; 9823-ENSSSCP00000018413; -.
DR Ensembl; ENSSSCT00000018918.5; ENSSSCP00000018413.4; ENSSSCG00000017379.5.
DR GeneID; 100516755; -.
DR CTD; 2118; -.
DR VGNC; VGNC:87813; ETV4.
DR eggNOG; KOG3806; Eukaryota.
DR GeneTree; ENSGT00940000158142; -.
DR HOGENOM; CLU_030025_1_0_1; -.
DR InParanoid; F1S1H2; -.
DR OrthoDB; 3915960at2759; -.
DR TreeFam; TF316214; -.
DR Reactome; R-SSC-5687128; MAPK6/MAPK4 signaling.
DR Proteomes; UP000008227; Chromosome 12.
DR Bgee; ENSSSCG00000017379; Expressed in hindlimb bud and 28 other cell types or tissues.
DR ExpressionAtlas; F1S1H2; baseline and differential.
DR GO; GO:0005694; C:chromosome; IEA:Ensembl.
DR GO; GO:0005730; C:nucleolus; IEA:Ensembl.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IEA:Ensembl.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IEA:Ensembl.
DR GO; GO:0045618; P:positive regulation of keratinocyte differentiation; IEA:Ensembl.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR000418; Ets_dom.
DR InterPro; IPR046328; ETS_fam.
DR InterPro; IPR006715; ETS_PEA3_N.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR11849; ETS; 1.
DR PANTHER; PTHR11849:SF181; ETS TRANSLOCATION VARIANT 4; 1.
DR Pfam; PF00178; Ets; 1.
DR Pfam; PF04621; ETS_PEA3_N; 1.
DR PRINTS; PR00454; ETSDOMAIN.
DR SMART; SM00413; ETS; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS00345; ETS_DOMAIN_1; 1.
DR PROSITE; PS00346; ETS_DOMAIN_2; 1.
DR PROSITE; PS50061; ETS_DOMAIN_3; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU004019};
KW Nucleus {ECO:0000256|RuleBase:RU004019};
KW Reference proteome {ECO:0000313|Proteomes:UP000008227}.
FT DOMAIN 342..422
FT /note="ETS"
FT /evidence="ECO:0000259|PROSITE:PS50061"
FT REGION 89..115
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 137..215
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 485 AA; 54005 MW; ABFE67C147FF1F43 CRC64;
MERRMKGGYL DQQVPYTFCS KSPGNGSLRE ALMVPQGKLM DPGSLPPPDS EDLFQDLSHF
QETWLAEAQV PDSDEQFVPD FHSENLAFHS PTTRIKKEPQ SPRTDPALSC SRKLPLPHHH
GEQCLYSSAY DPSRQIAIKS PAPGAPGQSP LQPFPRAEQR SFLRSSGTSQ PHPGHGYLGE
HGSLFQQPLD VCHSFTSSQG GGREPLPAPY QHQLSEPCPP YPQQSFKQEY LDPLYEQAGQ
PAVGQGGVNG HRYPGAGVVI KQEQTDFSYD SDVPGYASMY LHTEAFSGPP PGEGTMGYGC
EKPLRPFPDD VCIVPEKFEG DIKQEGVGAF REGPPYQRRG ALQLWQFLVA LLDDPTNAHF
IAWTGRGMEF KLIEPEEVAR LWGIQKNRPA MNYDKLSRSL RYYYEKGIMQ KVAGERYVYK
FVCEPEALFS LAFPDNQRPA LKAEFDRPVS EEDTVPLSHL DESPAYLPEL AGPAQPFGPK
GGYSY
//
