ID F1S1M3_PIG Unreviewed; 465 AA.
AC F1S1M3;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 03-MAY-2011, sequence version 1.
DT 27-MAR-2024, entry version 90.
DE RecName: Full=Sushi repeat-containing protein SRPX2 {ECO:0000256|ARBA:ARBA00014594};
GN Name=SRPX2 {ECO:0000313|Ensembl:ENSSSCP00000013277.1};
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00000013277.1, ECO:0000313|Proteomes:UP000008227};
RN [1] {ECO:0000313|Ensembl:ENSSSCP00000013277.1, ECO:0000313|Proteomes:UP000008227}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000013277.1,
RC ECO:0000313|Proteomes:UP000008227};
RG Porcine genome sequencing project;
RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:HDA82917.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=30723633; DOI=.7717/peerj.6374;
RA Gilbert D.G.;
RT "Genes of the pig, Sus scrofa, reconstructed with EvidentialGene.";
RL PeerJ 7:E6374-E6374(2019).
RN [3] {ECO:0000313|Ensembl:ENSSSCP00000013277.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell surface {ECO:0000256|ARBA:ARBA00004241}.
CC Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Secreted
CC {ECO:0000256|ARBA:ARBA00004613}. Synapse
CC {ECO:0000256|ARBA:ARBA00034103}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00302}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; DQIR01127441; HDA82917.1; -; Transcribed_RNA.
DR RefSeq; XP_001924554.3; XM_001924519.4.
DR PaxDb; 9823-ENSSSCP00000013277; -.
DR Ensembl; ENSSSCT00000013649.4; ENSSSCP00000013277.1; ENSSSCG00000012482.5.
DR GeneID; 100153130; -.
DR KEGG; ssc:100153130; -.
DR CTD; 27286; -.
DR eggNOG; ENOG502QREP; Eukaryota.
DR GeneTree; ENSGT00940000159149; -.
DR HOGENOM; CLU_047011_0_0_1; -.
DR OMA; EQRDMCE; -.
DR OrthoDB; 5406861at2759; -.
DR TreeFam; TF336515; -.
DR Proteomes; UP000008227; Chromosome X.
DR Bgee; ENSSSCG00000012482; Expressed in subcutaneous adipose tissue and 26 other cell types or tissues.
DR Genevisible; F1S1M3; SS.
DR GO; GO:0009986; C:cell surface; IEA:UniProtKB-SubCell.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005615; C:extracellular space; IEA:Ensembl.
DR GO; GO:0045202; C:synapse; IEA:UniProtKB-SubCell.
DR GO; GO:0036458; F:hepatocyte growth factor binding; IEA:Ensembl.
DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central.
DR GO; GO:0001525; P:angiogenesis; IEA:UniProtKB-KW.
DR GO; GO:0048870; P:cell motility; IEA:Ensembl.
DR GO; GO:0098609; P:cell-cell adhesion; IBA:GO_Central.
DR GO; GO:0090050; P:positive regulation of cell migration involved in sprouting angiogenesis; IBA:GO_Central.
DR GO; GO:0051965; P:positive regulation of synapse assembly; IBA:GO_Central.
DR GO; GO:0042325; P:regulation of phosphorylation; IEA:Ensembl.
DR GO; GO:0071625; P:vocalization behavior; IEA:Ensembl.
DR CDD; cd00033; CCP; 3.
DR Gene3D; 2.10.70.10; Complement Module, domain 1; 3.
DR InterPro; IPR025232; DUF4174.
DR InterPro; IPR003410; HYR_dom.
DR InterPro; IPR043555; SRPX-like.
DR InterPro; IPR035976; Sushi/SCR/CCP_sf.
DR InterPro; IPR000436; Sushi_SCR_CCP_dom.
DR PANTHER; PTHR46343; HYR DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR46343:SF3; SUSHI REPEAT-CONTAINING PROTEIN SRPX2; 1.
DR Pfam; PF13778; DUF4174; 1.
DR Pfam; PF02494; HYR; 1.
DR Pfam; PF00084; Sushi; 3.
DR SMART; SM00032; CCP; 3.
DR SUPFAM; SSF57535; Complement control module/SCR domain; 3.
DR PROSITE; PS50825; HYR; 1.
DR PROSITE; PS50923; SUSHI; 3.
PE 4: Predicted;
KW Angiogenesis {ECO:0000256|ARBA:ARBA00022657};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00302}; Reference proteome {ECO:0000313|Proteomes:UP000008227};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Sushi {ECO:0000256|ARBA:ARBA00022659, ECO:0000256|PROSITE-
KW ProRule:PRU00302}; Synapse {ECO:0000256|ARBA:ARBA00023018}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..465
FT /note="Sushi repeat-containing protein SRPX2"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5041116832"
FT DOMAIN 69..119
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 120..178
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 177..261
FT /note="HYR"
FT /evidence="ECO:0000259|PROSITE:PS50825"
FT DOMAIN 262..321
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DISULFID 149..176
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 292..319
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
SQ SEQUENCE 465 AA; 52917 MW; F5C2789A6D9C6BEB CRC64;
MALQLTQRGA LSLLLFLTPA VTPTWYAGSG YYPDESYNEV YAEEVPQAPA LDYRVPRWCY
TLNIQDGEAT CYSPRGGNYH SSLGTRCELS CDRGFRLIGR RSVQCLPSRR WSGTAYCRQM
RCHALPIITS GTYTCTNGVL LDSRCDYSCS SGYHLEGDRS RICMEDGQWS GGEPVCVDID
PPKIRCPHSR EKMAEPEKLT ARVYWDPPLV KDSADGTITR VTLRGPEPGS QFPEGEHVIR
YTAYDRAYNR ASCKFIIKVQ VRRCPTLKPP QHGYLTCTSA GDNYGATCEY HCDGGYERQG
TPSRVCQSSR QWSGSPPVCA PMKINVNVNS AAGLLDQFYE KRRLLIISAP DPSNRYYKMQ
ISMLQQSTCG LDLRHVTIIE LVGQPPQEVG RIREQQLSAN IIEELRQFQH LTRSYFNMVL
IDKQGIDRER YMEPVTPEEI FTFIDDYLLS DQELTQRREQ RDMCE
//
