ID F1S1R0_PIG Unreviewed; 706 AA.
AC F1S1R0;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2022, sequence version 4.
DT 27-MAR-2024, entry version 80.
DE SubName: Full=Ribosomal protein S6 kinase A6 {ECO:0000313|Ensembl:ENSSSCP00000013254.4};
GN Name=RPS6KA6 {ECO:0000313|Ensembl:ENSSSCP00000013254.4,
GN ECO:0000313|VGNC:VGNC:92445};
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00000013254.4, ECO:0000313|Proteomes:UP000008227};
RN [1] {ECO:0000313|Ensembl:ENSSSCP00000013254.4, ECO:0000313|Proteomes:UP000008227}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000013254.4,
RC ECO:0000313|Proteomes:UP000008227};
RG Porcine genome sequencing project;
RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSSCP00000013254.4}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- SIMILARITY: Belongs to the protein kinase superfamily. AGC Ser/Thr
CC protein kinase family. S6 kinase subfamily.
CC {ECO:0000256|ARBA:ARBA00009804}.
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DR AlphaFoldDB; F1S1R0; -.
DR STRING; 9823.ENSSSCP00000013254; -.
DR PaxDb; 9823-ENSSSCP00000013254; -.
DR PeptideAtlas; F1S1R0; -.
DR Ensembl; ENSSSCT00000013622.5; ENSSSCP00000013254.4; ENSSSCG00000012456.6.
DR VGNC; VGNC:92445; RPS6KA6.
DR eggNOG; KOG0603; Eukaryota.
DR GeneTree; ENSGT00940000159242; -.
DR HOGENOM; CLU_000288_58_3_1; -.
DR InParanoid; F1S1R0; -.
DR OrthoDB; 5489497at2759; -.
DR TreeFam; TF313438; -.
DR Reactome; R-SSC-442742; CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling.
DR Reactome; R-SSC-444257; RSK activation.
DR Proteomes; UP000008227; Chromosome X.
DR Bgee; ENSSSCG00000012456; Expressed in pituitary gland and 31 other cell types or tissues.
DR ExpressionAtlas; F1S1R0; baseline and differential.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005654; C:nucleoplasm; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000287; F:magnesium ion binding; IEA:InterPro.
DR GO; GO:0004711; F:ribosomal protein S6 kinase activity; IBA:GO_Central.
DR GO; GO:0006978; P:DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator; IBA:GO_Central.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd05582; STKc_RSK_N; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 2.
DR InterPro; IPR000961; AGC-kinase_C.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR017892; Pkinase_C.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR016239; Ribosomal_S6_kinase_II.
DR InterPro; IPR041906; RSK_N.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR PANTHER; PTHR24351; RIBOSOMAL PROTEIN S6 KINASE; 1.
DR PANTHER; PTHR24351:SF246; RIBOSOMAL PROTEIN S6 KINASE ALPHA-6; 1.
DR Pfam; PF00069; Pkinase; 2.
DR Pfam; PF00433; Pkinase_C; 1.
DR PIRSF; PIRSF000606; Ribsml_S6_kin_2; 1.
DR SMART; SM00133; S_TK_X; 1.
DR SMART; SM00220; S_TKc; 2.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 2.
DR PROSITE; PS51285; AGC_KINASE_CTER; 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 2.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 2.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PIRSR:PIRSR000606-
KW 51}; Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|PIRSR:PIRSR000606-51};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000008227};
KW Serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00022527};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 34..291
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT DOMAIN 292..361
FT /note="AGC-kinase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51285"
FT DOMAIN 387..644
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT ACT_SITE 159
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000606-50"
FT ACT_SITE 504
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000606-50"
FT BINDING 66
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PIRSR:PIRSR000606-51"
FT BINDING 393..401
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PIRSR:PIRSR000606-51"
FT BINDING 416
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PIRSR:PIRSR000606-51,
FT ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 706 AA; 79631 MW; 11C7A103D46AB22F CRC64;
MGLSTSAIWK NTGVEIVNPY EVKRKVKVNG LKMVDEPMEE GEADSCQVFL VRKKTGPDAG
QLYAMKVLKK ASLKVRDRVR TKMERDILVE VNHPFIVKLH YAFQTEGKLY LILDFLRGGD
VFTRLSKEVL FTEEDVKFYL AELALALDHL HRLGIVYRDL KPENILLDEI GHIKLTDFGL
SKEAVDQEKK AYSFCGTVEY MAPEVVNRRG HSQSADWWSY GVLMFEMLTG TLPFQGKDRN
ETMNMILKAK LGMPQFLSAE AQSLLRMLFK RNPANRLGSE GVDEIKRHLF FANIDWNKLY
KREVHPPFKP ASGKPDDTFC FDPEFTAKTP KDSPGLPASA NAHQLFKGFS FVATSIAEEY
KITPITSTNV LPIVQVNGNA AQFGEMYELK EDIGVGSYSV CKRCIHSATS MEFAVKIIDK
SKRDPSEEIE ILMHYGQHPN IITLKDVYDD GRYVYLVTDL MKGGELLDRI LKQKCFSERE
ASDVLFIITK TVDYLHCQGV VHRDLKPSNI LYMDESANAD SIKICDFGFA KQLRGENGLL
LTPCYTANFV APEVLMQQGY DAACDIWSLG VLFYTMLAGY TPFANGPNDT PEEILLRIGN
GKFSLSGGNW DSISDGAKDL LSHMLHMDPQ QRYTTEQVLK HSWITHRDQL PNDQPNRNDT
SQAVKGAMVA TYSALTHNTF QPVLEPVAAS SLAQRRSMKK RTSTGL
//
