ID F1S2T5_PIG Unreviewed; 1770 AA.
AC F1S2T5;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 3.
DT 27-MAR-2024, entry version 85.
DE SubName: Full=Latent transforming growth factor beta binding protein 2 {ECO:0000313|Ensembl:ENSSSCP00000002566.3};
GN Name=LTBP2 {ECO:0000313|Ensembl:ENSSSCP00000002566.3,
GN ECO:0000313|VGNC:VGNC:89886};
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00000002566.3, ECO:0000313|Proteomes:UP000008227};
RN [1] {ECO:0000313|Ensembl:ENSSSCP00000002566.3, ECO:0000313|Proteomes:UP000008227}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000002566.3,
RC ECO:0000313|Proteomes:UP000008227};
RG Porcine genome sequencing project;
RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSSCP00000002566.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC matrix {ECO:0000256|ARBA:ARBA00004498}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR RefSeq; XP_005656461.1; XM_005656404.2.
DR PeptideAtlas; F1S2T5; -.
DR Ensembl; ENSSSCT00000002632.4; ENSSSCP00000002566.3; ENSSSCG00000002368.5.
DR GeneID; 100514300; -.
DR KEGG; ssc:100514300; -.
DR CTD; 4053; -.
DR VGNC; VGNC:89886; LTBP2.
DR eggNOG; KOG1217; Eukaryota.
DR GeneTree; ENSGT00940000160884; -.
DR HOGENOM; CLU_001884_1_0_1; -.
DR OrthoDB; 354414at2759; -.
DR Proteomes; UP000008227; Chromosome 7.
DR Bgee; ENSSSCG00000002368; Expressed in lung and 39 other cell types or tissues.
DR ExpressionAtlas; F1S2T5; baseline and differential.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR CDD; cd00054; EGF_CA; 14.
DR Gene3D; 2.10.25.10; Laminin; 18.
DR Gene3D; 3.90.290.10; TGF-beta binding (TB) domain; 4.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR013032; EGF-like_CS.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR017878; TB_dom.
DR InterPro; IPR036773; TB_dom_sf.
DR PANTHER; PTHR24034; EGF-LIKE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR24034:SF166; VACUOLAR-SORTING RECEPTOR 1; 1.
DR Pfam; PF00008; EGF; 2.
DR Pfam; PF07645; EGF_CA; 14.
DR Pfam; PF12661; hEGF; 1.
DR Pfam; PF00683; TB; 4.
DR SMART; SM00181; EGF; 19.
DR SMART; SM00179; EGF_CA; 17.
DR SUPFAM; SSF57196; EGF/Laminin; 5.
DR SUPFAM; SSF57184; Growth factor receptor domain; 4.
DR SUPFAM; SSF57581; TB module/8-cys domain; 4.
DR PROSITE; PS00010; ASX_HYDROXYL; 11.
DR PROSITE; PS00022; EGF_1; 2.
DR PROSITE; PS01186; EGF_2; 8.
DR PROSITE; PS50026; EGF_3; 14.
DR PROSITE; PS01187; EGF_CA; 6.
DR PROSITE; PS51364; TB; 4.
PE 1: Evidence at protein level;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Extracellular matrix {ECO:0000256|ARBA:ARBA00022530};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Proteomics identification {ECO:0007829|PeptideAtlas:F1S2T5};
KW Reference proteome {ECO:0000313|Proteomes:UP000008227};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022530};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..35
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 36..1770
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5011619849"
FT DOMAIN 182..214
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 385..417
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 541..584
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 661..713
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 837..879
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 880..916
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 923..962
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1003..1043
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1128..1168
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1169..1210
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1211..1248
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1252..1289
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1360..1412
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 1434..1476
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1477..1512
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1533..1585
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 1682..1718
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1723..1767
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT REGION 37..61
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 75..154
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 220..282
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 418..439
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 484..532
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 738..761
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 41..55
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 114..135
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 266..282
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 423..437
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 508..522
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 186..196
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 204..213
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 389..399
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 407..416
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1481..1491
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 1770 AA; 191015 MW; 217BA61CE76725E6 CRC64;
MRPSTTRRCP GRALRNPWRS FLPLTLALFV GLGHAQRDPV GRYEPAGRDA NRLRRPGGSH
PAAAAAKVYG LFRDQDASVP GLPPEERAQP GWGSARRPAE TEARRPPRAQ QPRRVQPPAQ
TWRSRSLSQQ QPASRDRAAA ALPRLGTVQR PRAARGRLTG RNVCGGQCCP GWTTANSTNH
CIKPVCQPPC QNRGSCSRPQ LCVCRSGFRG ARCEEVIPEE EFDPQNSRPA PRRSAEGSPN
LRRSSAARES STARMRPPAP QPPPARTLSR LSQTHPSQQH MGLSQTVRLY PAAAASGQLT
SNALPVGPGP ERRDGAQQTA YVDHLSSPWG LNLTEKIKKI KIVFTPTICK QTCAHGRCAN
SCERGDTTTL YSQGGHGHDP KSGFRIYFCQ IPCLNGGRCI GRDECWCPAN STGKFCHLPA
PRLDPEPPER GPRHRTPLEG SLKQSTFTLP LSNQLASVNP SLVKVHIHHP PEASVQVHQV
ARVRGEAEGA PEENSVETRP SPRFPTGPGH SPWSSNSIPT RSREAPRPPP PAVPRLRPLL
GRCYLSAVNG QCANPLLELT AQEDCCGSVG AFWGVTSCAP CPPRPASPVI ENGQLECPQG
YKRLNLTHCQ DVNECLTLGL CEDSECVNTR GSYLCTCRPG LLLDPSRSRC VSDKAVSMQQ
GLCYRLLGPG TCALPLAQRI TKQICCCSRV GKAWGSKCET CPLPGTEAFR EICPAGHGYT
YSSSDIRLSM RKAEEEELAR PSWEHVQKSH GTPPGPADRQ PLRAATGTWL EAGTIPDKGD
TQAGQVTTSV TQLATWVPGD AIGRPTPSLP ARGIPEAQEE EQVTAPTDVL VTPAPPAIDR
CATGATNICG PGTCVNLPDG YKCICSPGYR LHPSQAYCTD DNECLRDPCK GRGRCVNRVG
SYSCFCYPGY MLATSGATQE CQDIDECEQP GLCSGGRCTN TVGSYHCECD QGYIMVRKGH
CQDINECRHP GTCPDGRCVN SPGSYTCLPC EEGYRGQSGS CVDVNECLTP GVCAHGTCLN
LEGSFRCSCE PGYEVTSDEK GCQDVDECAS RASCPTGLCL NTEGSFTCSA CESGYWVNED
GTACEDLDEC AFPGVCPSGV CANTAGSFSC RDCEEGYRPS ALGHTCEDVD ECADPQSRCL
GGECKNTAGS YQCLCPQGFQ LTNGSVCEDV DECVGEEYCA PRGECLNSHG SFFCLCAPGF
ASADGGTSCQ DVDECAVTDR CLRGQCVNTE GSFNCLCETG FQPSPESEEC VDIDECANDT
VCGSHGYCDN TEGSFRCLCD QGFETSASGW DCVDVNECEL MLAVCGTALC ENVEGSFLCL
CANDLEEYDA QEGHCRPRLA GGQSIPEASP GDRSPVPIRM ECYSGQKGQP PCSSLLGRNT
TQAECCCTQG TGWGDACDLC PAEDSVEFSE ICPSGKGYVP VEGAWMFGQT TYTDADECVM
FGHALCRNGR CLNTVPGYIC LCNPGYHYDA SRHKCEDHDE CQDMACENGE CVNTEGSFHC
FCSPPLTLDL SQQRCVNSTS GLEDLPDHDI HTDICWKKVT NYVCSHPLHG RRTTYTECCC
QDGEAWSQQC ALCPPRSSEV YAQLCNVARI EAEREAGVHF RPGYEYGPGP EDLHYGLYGP
EGAPFYNYLG PEDAIPEPLF PNTVSRPEDH TLVLEPPLQP SELQPHYVAS HPENQAGFEG
LQAEECGILN GCDNGRCVRV REGYTCDCFE GFQLDTAQMA CVDVNECDDL NGPAALCVHG
HCENTEGSYR CHCPPGYVAE AGPPHCTAKE
//
