ID F1S3F6_PIG Unreviewed; 361 AA.
AC F1S3F6;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 3.
DT 27-MAR-2024, entry version 87.
DE RecName: Full=Visual system homeobox 2 {ECO:0000256|ARBA:ARBA00014891};
DE AltName: Full=Ceh-10 homeodomain-containing homolog {ECO:0000256|ARBA:ARBA00030203};
DE AltName: Full=Homeobox protein CHX10 {ECO:0000256|ARBA:ARBA00031274};
GN Name=VSX2 {ECO:0000313|Ensembl:ENSSSCP00000002561.3,
GN ECO:0000313|VGNC:VGNC:94876};
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00000002561.3, ECO:0000313|Proteomes:UP000008227};
RN [1] {ECO:0000313|Ensembl:ENSSSCP00000002561.3, ECO:0000313|Proteomes:UP000008227}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000002561.3,
RC ECO:0000313|Proteomes:UP000008227};
RG Porcine genome sequencing project;
RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSSCP00000002561.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PROSITE-ProRule:PRU00108, ECO:0000256|RuleBase:RU000682}.
CC -!- SIMILARITY: Belongs to the paired homeobox family.
CC {ECO:0000256|ARBA:ARBA00005733}.
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DR AlphaFoldDB; F1S3F6; -.
DR SMR; F1S3F6; -.
DR STRING; 9823.ENSSSCP00000002561; -.
DR PaxDb; 9823-ENSSSCP00000002561; -.
DR PeptideAtlas; F1S3F6; -.
DR Ensembl; ENSSSCT00000002627.4; ENSSSCP00000002561.3; ENSSSCG00000002363.4.
DR VGNC; VGNC:94876; VSX2.
DR eggNOG; KOG0494; Eukaryota.
DR GeneTree; ENSGT00940000157776; -.
DR HOGENOM; CLU_049243_0_0_1; -.
DR InParanoid; F1S3F6; -.
DR OMA; MEQDERG; -.
DR OrthoDB; 2881066at2759; -.
DR TreeFam; TF350743; -.
DR Proteomes; UP000008227; Chromosome 7.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; IEA:Ensembl.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IEA:Ensembl.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0050896; P:response to stimulus; IEA:UniProtKB-KW.
DR GO; GO:0007601; P:visual perception; IEA:UniProtKB-KW.
DR CDD; cd00086; homeodomain; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR InterPro; IPR023339; CVC.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR003654; OAR_dom.
DR PANTHER; PTHR46892; VISUAL SYSTEM HOMEOBOX 2; 1.
DR PANTHER; PTHR46892:SF1; VISUAL SYSTEM HOMEOBOX 2; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR Pfam; PF03826; OAR; 1.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR PROSITE; PS51496; CVC; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
DR PROSITE; PS50803; OAR; 1.
PE 1: Evidence at protein level;
KW Activator {ECO:0000256|ARBA:ARBA00023159};
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Homeobox {ECO:0000256|ARBA:ARBA00023155, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Proteomics identification {ECO:0007829|PeptideAtlas:F1S3F6};
KW Reference proteome {ECO:0000313|Proteomes:UP000008227};
KW Sensory transduction {ECO:0000256|ARBA:ARBA00022606};
KW Vision {ECO:0000256|ARBA:ARBA00023305}.
FT DOMAIN 146..206
FT /note="Homeobox"
FT /evidence="ECO:0000259|PROSITE:PS50071"
FT DOMAIN 208..261
FT /note="CVC"
FT /evidence="ECO:0000259|PROSITE:PS51496"
FT DOMAIN 304..317
FT /note="OAR"
FT /evidence="ECO:0000259|PROSITE:PS50803"
FT DNA_BIND 148..207
FT /note="Homeobox"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
FT REGION 1..28
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 105..151
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 263..361
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 112..126
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 263..289
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 361 AA; 39292 MW; EF88D1B0DDADC13B CRC64;
MTGKAGEALS KPKAETVAKS TSGSAPARCT GFGIQEILGL NKEPPSSHPR AALDGLAPGH
LLAARSVLSP AGVGGMGLLG PGGLPGFYAQ PTFLEVLSDP QSVHLQPLGR ASGPLDTSQT
ASSDSEDVSS SDRKMSKSAL NQTKKRKKRR HRTIFTSYQL EELEKAFNEA HYPDVYAREM
LAMKTELPED RIQVWFQNRR AKWRKREKCW GRSSVMAEYG LYGAMVRHSI PLPESILKSA
KDGIMDSCAP WLLGMHKKSL EAAAESGRKP EAERQALPKL DKVEQEERGP DGPATMSQEE
LRENSIAALR ARAQEHSTKV LGTVSGPDSL ARSAEEPDEE EATDEDRPAE KLSPPQLEDM
A
//
