ID F1S425_PIG Unreviewed; 872 AA.
AC F1S425;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 3.
DT 27-MAR-2024, entry version 87.
DE SubName: Full=Glutamate metabotropic receptor 6 {ECO:0000313|Ensembl:ENSSSCP00000014914.3};
DE SubName: Full=Metabotropic glutamate receptor 6 {ECO:0000313|EMBL:HDA75024.1};
GN Name=GRM6 {ECO:0000313|Ensembl:ENSSSCP00000014914.3,
GN ECO:0000313|VGNC:VGNC:88704};
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00000014914.3, ECO:0000313|Proteomes:UP000008227};
RN [1] {ECO:0000313|Ensembl:ENSSSCP00000014914.3, ECO:0000313|Proteomes:UP000008227}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000014914.3,
RC ECO:0000313|Proteomes:UP000008227};
RG Porcine genome sequencing project;
RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:HDA75024.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=30723633; DOI=.7717/peerj.6374;
RA Gilbert D.G.;
RT "Genes of the pig, Sus scrofa, reconstructed with EvidentialGene.";
RL PeerJ 7:E6374-E6374(2019).
RN [3] {ECO:0000313|Ensembl:ENSSSCP00000014914.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 3 family.
CC {ECO:0000256|ARBA:ARBA00007242}.
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DR EMBL; DQIR01119548; HDA75024.1; -; Transcribed_RNA.
DR RefSeq; XP_013842991.1; XM_013987537.1.
DR STRING; 9823.ENSSSCP00000014914; -.
DR PaxDb; 9823-ENSSSCP00000014914; -.
DR Ensembl; ENSSSCT00000015322.4; ENSSSCP00000014914.3; ENSSSCG00000014027.4.
DR VGNC; VGNC:88704; GRM6.
DR eggNOG; KOG1056; Eukaryota.
DR GeneTree; ENSGT01030000234648; -.
DR HOGENOM; CLU_005389_0_0_1; -.
DR OMA; EACPRDM; -.
DR TreeFam; TF313240; -.
DR Reactome; R-SSC-418594; G alpha (i) signalling events.
DR Reactome; R-SSC-420499; Class C/3 (Metabotropic glutamate/pheromone receptors).
DR Proteomes; UP000008227; Chromosome 2.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:Ensembl.
DR GO; GO:0000139; C:Golgi membrane; IEA:Ensembl.
DR GO; GO:0035841; C:new growing cell tip; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0001640; F:adenylate cyclase inhibiting G protein-coupled glutamate receptor activity; IBA:GO_Central.
DR GO; GO:0042803; F:protein homodimerization activity; IEA:Ensembl.
DR GO; GO:0050908; P:detection of light stimulus involved in visual perception; IEA:Ensembl.
DR GO; GO:0007216; P:G protein-coupled glutamate receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0007626; P:locomotory behavior; IEA:Ensembl.
DR GO; GO:1905665; P:positive regulation of calcium ion import across plasma membrane; IEA:Ensembl.
DR GO; GO:0051966; P:regulation of synaptic transmission, glutamatergic; IBA:GO_Central.
DR GO; GO:0060041; P:retina development in camera-type eye; IEA:Ensembl.
DR CDD; cd15453; 7tmC_mGluR6; 1.
DR CDD; cd06376; PBP1_mGluR_groupIII; 1.
DR Gene3D; 3.40.50.2300; -; 2.
DR Gene3D; 2.10.50.30; GPCR, family 3, nine cysteines domain; 1.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR000337; GPCR_3.
DR InterPro; IPR011500; GPCR_3_9-Cys_dom.
DR InterPro; IPR038550; GPCR_3_9-Cys_sf.
DR InterPro; IPR000112; GPCR_3__mGluR6.
DR InterPro; IPR017978; GPCR_3_C.
DR InterPro; IPR017979; GPCR_3_CS.
DR InterPro; IPR000162; GPCR_3_mtglu_rcpt.
DR InterPro; IPR028082; Peripla_BP_I.
DR PANTHER; PTHR24060; METABOTROPIC GLUTAMATE RECEPTOR; 1.
DR PANTHER; PTHR24060:SF24; METABOTROPIC GLUTAMATE RECEPTOR 6; 1.
DR Pfam; PF00003; 7tm_3; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR Pfam; PF07562; NCD3G; 1.
DR PRINTS; PR00248; GPCRMGR.
DR PRINTS; PR01056; MTABOTROPC6R.
DR PRINTS; PR00593; MTABOTROPICR.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR PROSITE; PS00979; G_PROTEIN_RECEP_F3_1; 1.
DR PROSITE; PS00980; G_PROTEIN_RECEP_F3_2; 1.
DR PROSITE; PS00981; G_PROTEIN_RECEP_F3_3; 1.
DR PROSITE; PS50259; G_PROTEIN_RECEP_F3_4; 1.
PE 1: Evidence at protein level;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Proteomics identification {ECO:0007829|PeptideAtlas:F1S425};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000313|EMBL:HDA75024.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000008227};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..872
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5041116824"
FT TRANSMEM 585..606
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 618..638
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 650..671
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 744..765
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 777..802
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 808..832
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 580..854
FT /note="G-protein coupled receptors family 3 profile"
FT /evidence="ECO:0000259|PROSITE:PS50259"
FT REGION 849..872
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 872 AA; 94487 MW; DAB7765CA32CC9EF CRC64;
MAGLLTLMPP LLALALAQAG VAGAAGSVRL AGGLTLGGLF PVHARGAAGR ACGPLKKEQG
VHRLEAMLYA LDRVNADPDL LPGVRLGARL LDTCSRDTYA LEQALSFVQA LIRGRGDGDE
AAVRCPGGVP PLRAAPPERV VAVVGASASS VSIMVANVLR LFAIPQISYA STAPELSDST
RYDFFSRVVP PDSYQAQAMV DIVRALGWNY VSTLASEGNY GESGVEAFVQ ISREAGGVCI
AQSIKIPREP KPGEFNKVIR RLMETPNARG IIIFANEDDI RRVLEAARQA NLTGHFLWVG
SDSWGAKISP ILNLEEVAVG AITILPKRAS IDGFDQYFMT RSLENNRRNI WFAEFWEENF
NCKLISSGTQ SDDSTRKCTG EERIGRDSAY EQEGKVQFVI DAVYAIAHAL HSMHQALCPG
HTGLCPAMEP TDGRTLLQYI RAVRFNGSAG TPVMFNENGD APGRYDIFQY QATNGSAGSG
GYQAVGQWAE TLRLDVEALQ WSGDPHEVPA SQCSLPCGPG ERKKMVKGVP CCWHCEACDG
YRFQVDEFTC EACPGHMRPT RNHTGCRPTP VVRLSWSSPW AAPPLLLAVL GIMATTTVVA
TFVRHNNTPI VRASGRELSY VLLTGIFLIY AITFLMVAEP GAAVCAARRL FLGLGTTLSY
SALLTKTNRI YRIFEQGKRS VTPPPFISPT SQLVITFSLT SVQVVGVMAW LGAQPPHSVI
DYEEQRTVDP EQARGVLKCD MSDLSLIGCL GYSLLLMVTC TVYAIKARGV PETFNEAKPI
GFTMYTTCII WLAFVPIFFG TAQSAEKIYI QTTTLTVSLS LSASVSLGML YVPKTYVILF
HPEQNVQKRK RSLKATSTVA APPKGEDTEA PK
//
