GenomeNet

Database: UniProt
Entry: F1S4U0_PIG
LinkDB: F1S4U0_PIG
Original site: F1S4U0_PIG 
ID   F1S4U0_PIG              Unreviewed;       465 AA.
AC   F1S4U0;
DT   03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 3.
DT   23-MAY-2018, entry version 50.
DE   RecName: Full=Triacylglycerol lipase {ECO:0000256|RuleBase:RU362046};
DE            EC=3.1.1.3 {ECO:0000256|RuleBase:RU362046};
DE   AltName: Full=Pancreatic lipase {ECO:0000256|RuleBase:RU362046};
GN   Name=PNLIPRP3 {ECO:0000313|Ensembl:ENSSSCP00000011354};
OS   Sus scrofa (Pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Suina; Suidae;
OC   Sus.
OX   NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00000011354, ECO:0000313|Proteomes:UP000008227};
RN   [1] {ECO:0000313|Ensembl:ENSSSCP00000011354, ECO:0000313|Proteomes:UP000008227}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000011354};
RG   Porcine genome sequencing project;
RL   Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSSSCP00000011354}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (MAY-2011) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY: Triacylglycerol + H(2)O = diacylglycerol + a
CC       carboxylate. {ECO:0000256|RuleBase:RU362046}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|RuleBase:RU362046,
CC       ECO:0000256|SAAS:SAAS00553472}.
CC   -!- SIMILARITY: Belongs to the AB hydrolase superfamily. Lipase
CC       family. {ECO:0000256|RuleBase:RU004262,
CC       ECO:0000256|SAAS:SAAS00591292}.
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DR   EMBL; AEMK02000096; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 9823.ENSSSCP00000011354; -.
DR   PaxDb; F1S4U0; -.
DR   PRIDE; F1S4U0; -.
DR   Ensembl; ENSSSCT00000011656; ENSSSCP00000011354; ENSSSCG00000010657.
DR   eggNOG; ENOG410IK4Z; Eukaryota.
DR   eggNOG; ENOG41118P1; LUCA.
DR   GeneTree; ENSGT00760000119069; -.
DR   InParanoid; F1S4U0; -.
DR   OrthoDB; EOG091G0DJ5; -.
DR   TreeFam; TF324997; -.
DR   Proteomes; UP000008227; Chromosome 14.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0004806; F:triglyceride lipase activity; IEA:UniProtKB-EC.
DR   GO; GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.
DR   CDD; cd00707; Pancreat_lipase_like; 1.
DR   Gene3D; 3.40.50.1820; -; 1.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR013818; Lipase/vitellogenin.
DR   InterPro; IPR016272; Lipase_LIPH.
DR   InterPro; IPR033906; Lipase_N.
DR   InterPro; IPR002331; Lipase_panc.
DR   InterPro; IPR001024; PLAT/LH2_dom.
DR   InterPro; IPR036392; PLAT/LH2_dom_sf.
DR   InterPro; IPR000734; TAG_lipase.
DR   PANTHER; PTHR11610; PTHR11610; 1.
DR   Pfam; PF00151; Lipase; 1.
DR   Pfam; PF01477; PLAT; 1.
DR   PIRSF; PIRSF000865; Lipoprotein_lipase_LIPH; 1.
DR   PRINTS; PR00823; PANCLIPASE.
DR   PRINTS; PR00821; TAGLIPASE.
DR   SUPFAM; SSF49723; SSF49723; 1.
DR   SUPFAM; SSF53474; SSF53474; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000008227};
KW   Disulfide bond {ECO:0000256|RuleBase:RU362046,
KW   ECO:0000256|SAAS:SAAS00709807};
KW   Lipid degradation {ECO:0000256|RuleBase:RU362046};
KW   Lipid metabolism {ECO:0000256|RuleBase:RU362046};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008227};
KW   Secreted {ECO:0000256|RuleBase:RU362046,
KW   ECO:0000256|SAAS:SAAS00439306};
KW   Signal {ECO:0000256|RuleBase:RU362046}.
FT   SIGNAL        1     18       {ECO:0000256|RuleBase:RU362046}.
FT   CHAIN        19    465       Triacylglycerol lipase.
FT                                {ECO:0000256|RuleBase:RU362046}.
FT                                /FTId=PRO_5011815653.
FT   DOMAIN       18    350       Lipase. {ECO:0000259|Pfam:PF00151}.
FT   DOMAIN      366    456       PLAT. {ECO:0000259|Pfam:PF01477}.
FT   ACT_SITE    166    166       Nucleophile. {ECO:0000256|PIRSR:
FT                                PIRSR000865-1}.
FT   ACT_SITE    189    189       Charge relay system. {ECO:0000256|PIRSR:
FT                                PIRSR000865-1}.
FT   ACT_SITE    277    277       Charge relay system. {ECO:0000256|PIRSR:
FT                                PIRSR000865-1}.
SQ   SEQUENCE   465 AA;  52106 MW;  382BB46D0F622A1C CRC64;
     SLGYWLVIFF SFWHPCLVCY ERVGCFKDGL PWTGTLSRQL AGLPWSPEEI NTRFLLYTRR
     NPKTHQEISA VNYLTIQASN FGTDKITHIN IPGWKSDGKW QQDMCNVLLK VEDVNCINLD
     WINGSQQYIQ AVNNLRVVGA EVAYFIDVLK QKFGYSPSKV HLIGHSLGAH LAGEAGSRTP
     GLGRITGLDP AGPYFHNTPK EVRLDPSDAN FVDVIHTNAV RFLFELGAGT INACGHLDFY
     PNGGKHMPGC EDLITPLFTF DLNVYKEEMS SFFECNHARS HRFYTESILN PDAFIAYPCR
     SYTSFKAGNC FHCPKEGCPT MGHFADRFHL KNREPNRSYY FLNTGTFSPF ARWRHKLSVK
     LDGNNVTQGS IFLRVGGTTG ETGEFGIISG TLKPGMTYTN LIDADINVGN ITSIEFIWKE
     HSFGHSQNKL GAEMVIDISG KYGYESTFCS QNVIGPNIAQ VLKPC
//
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