ID F1S539_PIG Unreviewed; 2320 AA.
AC F1S539;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 2.
DT 27-MAR-2024, entry version 84.
DE SubName: Full=ATP binding cassette subfamily A member 4 {ECO:0000313|Ensembl:ENSSSCP00000007345.3};
GN Name=ABCA4 {ECO:0000313|Ensembl:ENSSSCP00000007345.3,
GN ECO:0000313|VGNC:VGNC:84948};
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00000007345.3, ECO:0000313|Proteomes:UP000008227};
RN [1] {ECO:0000313|Ensembl:ENSSSCP00000007345.3, ECO:0000313|Proteomes:UP000008227}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000007345.3,
RC ECO:0000313|Proteomes:UP000008227};
RG Porcine genome sequencing project;
RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSSCP00000007345.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR SMR; F1S539; -.
DR STRING; 9823.ENSSSCP00000007345; -.
DR PaxDb; 9823-ENSSSCP00000007345; -.
DR PeptideAtlas; F1S539; -.
DR Ensembl; ENSSSCT00000007545.5; ENSSSCP00000007345.3; ENSSSCG00000006890.5.
DR VGNC; VGNC:84948; ABCA4.
DR eggNOG; KOG0059; Eukaryota.
DR GeneTree; ENSGT00940000155624; -.
DR HOGENOM; CLU_000604_19_0_1; -.
DR InParanoid; F1S539; -.
DR OMA; EVHQSMG; -.
DR TreeFam; TF105191; -.
DR Reactome; R-SSC-2453902; The canonical retinoid cycle in rods (twilight vision).
DR Reactome; R-SSC-382556; ABC-family proteins mediated transport.
DR Proteomes; UP000008227; Chromosome 4.
DR Bgee; ENSSSCG00000006890; Expressed in granulosa cell and 12 other cell types or tissues.
DR ExpressionAtlas; F1S539; baseline and differential.
DR GO; GO:0031410; C:cytoplasmic vesicle; IEA:Ensembl.
DR GO; GO:0005783; C:endoplasmic reticulum; IEA:Ensembl.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IBA:GO_Central.
DR GO; GO:0001750; C:photoreceptor outer segment; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IEA:InterPro.
DR GO; GO:0005502; F:11-cis retinal binding; IEA:Ensembl.
DR GO; GO:0140359; F:ABC-type transporter activity; IEA:InterPro.
DR GO; GO:0005503; F:all-trans retinal binding; IEA:Ensembl.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:Ensembl.
DR GO; GO:0140326; F:ATPase-coupled intramembrane lipid transporter activity; IBA:GO_Central.
DR GO; GO:0042626; F:ATPase-coupled transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0140347; F:N-retinylidene-phosphatidylethanolamine flippase activity; IEA:Ensembl.
DR GO; GO:0090555; F:phosphatidylethanolamine flippase activity; IEA:Ensembl.
DR GO; GO:0005548; F:phospholipid transporter activity; IBA:GO_Central.
DR GO; GO:0006869; P:lipid transport; IBA:GO_Central.
DR GO; GO:0006649; P:phospholipid transfer to membrane; IEA:Ensembl.
DR GO; GO:0045332; P:phospholipid translocation; IEA:Ensembl.
DR GO; GO:0045494; P:photoreceptor cell maintenance; IEA:Ensembl.
DR GO; GO:0042574; P:retinal metabolic process; IEA:Ensembl.
DR GO; GO:0007601; P:visual perception; IEA:Ensembl.
DR CDD; cd03263; ABC_subfamily_A; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR013525; ABC2_TM.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR026082; ABCA.
DR InterPro; IPR005951; ABCA4/ABCR.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR01257; rim_protein; 1.
DR PANTHER; PTHR19229; ATP-BINDING CASSETTE TRANSPORTER SUBFAMILY A ABCA; 1.
DR PANTHER; PTHR19229:SF190; RETINAL-SPECIFIC PHOSPHOLIPID-TRANSPORTING ATPASE ABCA4; 1.
DR Pfam; PF12698; ABC2_membrane_3; 2.
DR Pfam; PF00005; ABC_tran; 2.
DR SMART; SM00382; AAA; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 2.
PE 1: Evidence at protein level;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Proteomics identification {ECO:0007829|PeptideAtlas:F1S539};
KW Reference proteome {ECO:0000313|Proteomes:UP000008227};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 23..42
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 655..675
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 695..719
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 731..751
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 758..778
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1365..1386
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1671..1693
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1713..1739
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1751..1770
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1782..1804
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 929..1160
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
FT DOMAIN 1929..2161
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
FT REGION 891..911
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1284..1336
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2320 AA; 259702 MW; D68497C39916C438 CRC64;
MGFARQIRLL LWKNWTLRKR QKIRFVVELV WPLSLFLVLI WLRNVNPLYS QHECHFPNKA
MPSAGMLPWL QGIFCNVNNP CFQSPTPGES PGIVSNYNNS ILARVYRDLQ ELLIEAPESQ
HLGQVWTELR TLSQLMNTLR THPERIAGRG IRIRDVLKDE ETLTLFLTKN IGLSDSVIDL
LINSQVHPEQ FAHGVPDLVL RDIACSEALL ERFLIFPQRR GVPAVREALC PLSQGALQWM
EDTLYANVDV FKLFRVLPRL VDGGSQGVDL RSWGRILSDM SPRIQEFIHR PSVQDLLWVT
RPLVQAGGPE TFTQLMDSLS GLLCGYPEGG GSRVFSFNWY EDNNYKAFLG IDSTRKDPVY
SYDKRTTTFC NALIQRLESN PLTKIAWRAA KPLLMGKILF TPDSPATRRI LKNANSTFEE
LERVRTLVRA WEEVGPQIWY FFDKSTPMAM IRDSLENPTV KAAFNRQFGE GGVTAEAILS
FLYRGPREGR ADDVASFDWR DVFNVTDRTL RLANQYLECL ILDKFESYDD EFQLTQRALS
LLEENRFWAG VVFPDLYPWT SSLPPHVRYK IRMDIDVVEK TNKIKDRYWD SGPRADPVED
FRYIWGGFAY LQDMVEQGIT RSQAQAEVPV GIYLQQMPYP CFVDDAFMII LNRCFPVFMV
LAWIYSVSMT VKSIVLEKEL RLKETLKNQG VSNAVIWCTW FLDSFSIMSM SICLLTLFIM
HGRILHYSNP FILFLFLLAF STATIMQCFL LSTCFSRANL AAACSGVIYF TLYLPHILCF
AWQDRMSADL KMAVSLLSPV AFGFGTEYLV RFEEQGLGLQ WSNIGNSPME GDEFSFLMSM
KMMLLDAALY GLLAWYLDHV FPGDYGTPLP WYFLLQESYW LGGEGCSTRE ERALEKTEPV
TEEMEDPEHP EGVNECFFER ELPGLVPGVC VKNLVKTFEP YGRPAVDRLN ITFYENQITA
FLGHNGAGKT TTLSIMTGLL PPTSGTVLVG GKDIETSLDA IRQSLGLCPQ HNILFHHLTV
AEHILFYAQL KGKPWEEAQL ETEAMLEDTG LHHKRNEEAQ HLSGGMQRKL SVAIAFVGDA
KVVVLDEPTS GVDPYSRRSI WDLLLKYRPG RTIIMSTHHM DEADLLGDRI AILAQGRLYC
AGTPLFLKSC FGTGFYLTLV RKTKTVQSHG RGCAGTCSCA SKGVSGRCPA CVNEMTPEQV
LDGDVSELVD VVHHHVPEAK LVECIGQELI FLLPSKNFKQ RAYASLFREL EETLADLGLS
SFGISDTPLE EIFLKVTEDS GPGPLFAGST RQNKEDVSLR HPCSGPPGKA RQTPQGTDGG
CPEPAPPLGG EGHGRLNTGA RLVAQHVQAL LVKRFHHTVR SRRDFLAQIV LPATFVCLAL
MLSIIIPPFG DYPALTLHPW MYGQQYTFFS MDQPDSELLA TLADVLVNKP GFGNRCLKGE
WLPEFPCGNS TPWKTPSVSP DVTHLLQKQK WTADQPSPAC RCSTREKLTM LPECPEGAGG
LRPRRIQRST EILQDLTGRN ISDFLVKTYP ALIRSSLKSK FWVNEQRYGG ISIGGKLPPP
PITAEALVEF LSDLGQLMNV SAGPFTREAS TEMSAFLKHL ETEDNIKVWF NNKGWHALVS
FLNVAHNAIL RASLREASSP EEHGITVISQ PLNLTKEQLS EITVLTTSVD AAVAICVIFA
MSFIPASFVL YLIQERVSQA KHLQFVSGVS PTTYWLTSFL WDMMNYAVSA ALVVSIFVGF
QKKAYTSPDN LPALVALLLL YGWAVIPMMY PASFLFDVPS TAYVALACAN LFIGINSSAI
TFVLELFENN QTLLRFNAML RKLLIIFPHF CLGRGLIDLA LSQAVTDVYA RFGEEHSSSP
FQWELIGKNL AAMAAEGVVY FLLTLLIQHQ FFFRRWTTEP ATEPIDNEDD DVAEERQRII
GGGTKTDILR LNELTKIYPG ASSPAVDRLC VGVRPGECFG LLGVNGAGKT TTFKMLTGDT
TVTSGDATVA GKSILTNIAD VHQSMGYCPQ FDAIDDLLTG REHLHLYARL RGVPAEEIKR
VTDWSIQSLG LSLYADCLAG TYSGGNKRKL STAIALIGCP PLLLLDEPTT GMDPQARRML
WNTIMGIIRE GRAVVLTSHS MEECEALCTR LAIMVKGAFQ CLGTTQHLKY KFGDGYIVTM
KIKSPKDDLL PDLGAVEQFF RGSFPGSVLR ERHHNMLQFQ VASASLARIF RLLVSHKDSL
LVEEYSVTQT TLDQVFVNFA KQQTEMTHDF PLHPRAAGAS RQAKVPLLLL PEHCLRQILG
SGTQLVPKAQ TCLLQKAPRF QPPPPPAMCH LLCAEGLFSP
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