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Database: UniProt
Entry: F1S6G8_PIG
LinkDB: F1S6G8_PIG
Original site: F1S6G8_PIG 
ID   F1S6G8_PIG              Unreviewed;       391 AA.
AC   F1S6G8;
DT   03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT   11-JUL-2012, sequence version 2.
DT   16-OCT-2019, entry version 60.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSSSCP00000016157};
GN   Name=KCNJ1 {ECO:0000313|Ensembl:ENSSSCP00000016157};
OS   Sus scrofa (Pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Suina; Suidae;
OC   Sus.
OX   NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00000016157, ECO:0000313|Proteomes:UP000008227};
RN   [1] {ECO:0000313|Ensembl:ENSSSCP00000016157, ECO:0000313|Proteomes:UP000008227}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000016157,
RC   ECO:0000313|Proteomes:UP000008227};
RG   Porcine genome sequencing project;
RL   Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSSSCP00000016157}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (MAY-2011) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003822};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003822}.
CC   -!- SIMILARITY: Belongs to the inward rectifier-type potassium channel
CC       (TC 1.A.2.1) family. {ECO:0000256|RuleBase:RU003822,
CC       ECO:0000256|SAAS:SAAS00549381}.
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DR   EMBL; AEMK02000070; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 9823.ENSSSCP00000016157; -.
DR   PaxDb; F1S6G8; -.
DR   PRIDE; F1S6G8; -.
DR   Ensembl; ENSSSCT00000016602; ENSSSCP00000016157; ENSSSCG00000015236.
DR   eggNOG; KOG3827; Eukaryota.
DR   eggNOG; ENOG410XQ62; LUCA.
DR   GeneTree; ENSGT00970000193347; -.
DR   InParanoid; F1S6G8; -.
DR   OMA; LWYWIAK; -.
DR   TreeFam; TF313676; -.
DR   Reactome; R-SSC-1296067; Potassium transport channels.
DR   Proteomes; UP000008227; Chromosome 9.
DR   Bgee; ENSSSCG00000015236; Expressed in 2 organ(s), highest expression level in adult mammalian kidney.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0015272; F:ATP-activated inward rectifier potassium channel activity; IBA:GO_Central.
DR   GO; GO:0005242; F:inward rectifier potassium channel activity; IBA:GO_Central.
DR   GO; GO:0005546; F:phosphatidylinositol-4,5-bisphosphate binding; IEA:Ensembl.
DR   GO; GO:1990573; P:potassium ion import across plasma membrane; IBA:GO_Central.
DR   GO; GO:0034765; P:regulation of ion transmembrane transport; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.40.1400; -; 1.
DR   InterPro; IPR014756; Ig_E-set.
DR   InterPro; IPR041647; IRK_C.
DR   InterPro; IPR016449; K_chnl_inward-rec_Kir.
DR   InterPro; IPR003268; K_chnl_inward-rec_Kir1.1.
DR   InterPro; IPR013518; K_chnl_inward-rec_Kir_cyto.
DR   InterPro; IPR040445; Kir_TM.
DR   PANTHER; PTHR11767; PTHR11767; 1.
DR   PANTHER; PTHR11767:SF6; PTHR11767:SF6; 1.
DR   Pfam; PF01007; IRK; 1.
DR   Pfam; PF17655; IRK_C; 1.
DR   PIRSF; PIRSF005465; GIRK_kir; 1.
DR   PRINTS; PR01320; KIRCHANNEL.
DR   SUPFAM; SSF81296; SSF81296; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000008227};
KW   Ion channel {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434609};
KW   Ion transport {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434639};
KW   Membrane {ECO:0000256|SAAS:SAAS00434581, ECO:0000256|SAM:Phobius};
KW   Potassium {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434575};
KW   Potassium transport {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434641};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008227};
KW   Transmembrane {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434543, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00036756,
KW   ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00036755};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00048561}.
FT   TRANSMEM     83    105       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    156    180       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       43    185       IRK. {ECO:0000259|Pfam:PF01007}.
FT   DOMAIN      192    363       IRK_C. {ECO:0000259|Pfam:PF17655}.
FT   SITE        171    171       Role in the control of polyamine-mediated
FT                                channel gating and in the blocking by
FT                                intracellular magnesium.
FT                                {ECO:0000256|PIRSR:PIRSR005465-1}.
SQ   SEQUENCE   391 AA;  44904 MW;  912A5CD1223E1455 CRC64;
     VDASGQKMFK TLIRVLTERM FKRVRKWFIT RIWGHSRRRA RLVSKDGRCN IEFGNVEAQS
     RLIFFVDIWT TVLDLKWRYK MTIFITAFLG SWFFFGLLWY AVAYIHKDLP EFHPPANHTP
     CVEHINGLTS AFLFSLETQV TIGYGFRCVT EQCGTAIFLL IFQSILGVII NSFMCGAILA
     KISRPKKRAK TITFSKNAVI SKRGGKLCLL IRVANLRKSL LIGSHIYGKL LKTTITPEGE
     TIILDQININ FVVDAGNENL FFISPLTIYH IIDHTSPFFH MAAETLPQQD FELVVFLDGT
     VESTSATCQV RTSYVPEEVL WGYRFAPIVS KTKEGKYRVD FHNFSKTVEV ETPHCAMCLY
     NEKDARARMK RGYDNPNFIL SEINETDDTK M
//
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