ID F1S8W2_PIG Unreviewed; 604 AA.
AC F1S8W2;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 3.
DT 27-MAR-2024, entry version 70.
DE SubName: Full=Ectonucleoside triphosphate diphosphohydrolase 7 {ECO:0000313|Ensembl:ENSSSCP00000011230.3};
GN Name=ENTPD7 {ECO:0000313|Ensembl:ENSSSCP00000011230.3,
GN ECO:0000313|VGNC:VGNC:87716};
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00000011230.3, ECO:0000313|Proteomes:UP000008227};
RN [1] {ECO:0000313|Ensembl:ENSSSCP00000011230.3, ECO:0000313|Proteomes:UP000008227}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000011230.3,
RC ECO:0000313|Proteomes:UP000008227};
RG Porcine genome sequencing project;
RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSSCP00000011230.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- SIMILARITY: Belongs to the GDA1/CD39 NTPase family.
CC {ECO:0000256|ARBA:ARBA00009283, ECO:0000256|RuleBase:RU003833}.
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DR AlphaFoldDB; F1S8W2; -.
DR SMR; F1S8W2; -.
DR STRING; 9823.ENSSSCP00000011230; -.
DR PaxDb; 9823-ENSSSCP00000011230; -.
DR Ensembl; ENSSSCT00000011531.4; ENSSSCP00000011230.3; ENSSSCG00000010540.5.
DR VGNC; VGNC:87716; ENTPD7.
DR eggNOG; KOG1386; Eukaryota.
DR GeneTree; ENSGT01100000263540; -.
DR HOGENOM; CLU_010246_6_0_1; -.
DR InParanoid; F1S8W2; -.
DR OMA; LNCATKQ; -.
DR OrthoDB; 180318at2759; -.
DR TreeFam; TF354343; -.
DR Reactome; R-SSC-8850843; Phosphate bond hydrolysis by NTPDase proteins.
DR Proteomes; UP000008227; Chromosome 14.
DR Bgee; ENSSSCG00000010540; Expressed in epididymis and 44 other cell types or tissues.
DR ExpressionAtlas; F1S8W2; baseline and differential.
DR GO; GO:0030659; C:cytoplasmic vesicle membrane; IEA:Ensembl.
DR GO; GO:0005794; C:Golgi apparatus; IBA:GO_Central.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0043273; F:CTPase activity; IEA:Ensembl.
DR GO; GO:0004382; F:GDP phosphatase activity; IBA:GO_Central.
DR GO; GO:0003924; F:GTPase activity; IEA:Ensembl.
DR GO; GO:0045134; F:UDP phosphatase activity; IBA:GO_Central.
DR GO; GO:0006254; P:CTP catabolic process; IEA:Ensembl.
DR GO; GO:0046039; P:GTP metabolic process; IEA:Ensembl.
DR GO; GO:0034656; P:nucleobase-containing small molecule catabolic process; IEA:Ensembl.
DR GO; GO:0050776; P:regulation of immune response; IEA:Ensembl.
DR GO; GO:0072539; P:T-helper 17 cell differentiation; IEA:Ensembl.
DR GO; GO:0006256; P:UDP catabolic process; IBA:GO_Central.
DR GO; GO:0046052; P:UTP catabolic process; IEA:Ensembl.
DR CDD; cd00012; NBD_sugar-kinase_HSP70_actin; 1.
DR Gene3D; 3.30.420.40; -; 1.
DR Gene3D; 3.30.420.150; Exopolyphosphatase. Domain 2; 1.
DR InterPro; IPR000407; GDA1_CD39_NTPase.
DR PANTHER; PTHR11782; ADENOSINE/GUANOSINE DIPHOSPHATASE; 1.
DR PANTHER; PTHR11782:SF37; ECTONUCLEOSIDE TRIPHOSPHATE DIPHOSPHOHYDROLASE 7; 1.
DR Pfam; PF01150; GDA1_CD39; 1.
DR PROSITE; PS01238; GDA1_CD39_NTPASE; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|PIRSR:PIRSR600407-2};
KW Hydrolase {ECO:0000256|RuleBase:RU003833};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|PIRSR:PIRSR600407-2};
KW Reference proteome {ECO:0000313|Proteomes:UP000008227};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 29..47
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 552..570
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT ACT_SITE 217
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR600407-1"
FT BINDING 261..265
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PIRSR:PIRSR600407-2"
SQ SEQUENCE 604 AA; 69145 MW; 8B83E1979E3BE437 CRC64;
MARISFSYLC PASWYFTVPT VSPFPRQRVA FLGLFFISCL LLLMLFMDFR HWGTSLPRDR
QYERYLARVG DLEATDTEDP NLNYGLVVDC GSSGSRIFVY FWPRHNGNPH DLLDIKQMRD
RNSQPVVKKI KPGISAMADT PEHSSDYLRP LLSFAAAHVP VRKHKETPLY ILCTAGMRLL
PERKQLAILA DLVKDLPLEF DFLFSQSQAE VISGKQEGVY AWIGINFVLG RFDHEDESDA
EAPQELATGR RRTVGILDMG GASLQIAYEV PTSTSVLPPQ QEEAAKILLA EFNLGCDVQH
TEHVYRVYVT TFLGFGGNFA RQRYEDLVLN ETLHKNRLLG QKTGLSPDNP FLDPCLPVGL
TDVVERNSQV LHVRGRGDWV ACRAMLNPLL ARSNTSQASL NGIYQSPIDF NNSEFYGFSE
FFYCTEDVLR IGGRYHGPTF AKAAQDYCGM AWSVLTQRFK NGLFSSHADE HRLKYQCFKS
AWMYQVLHEG FHFPYDYPNL QTAQLVYDRE VQWTLGAILY KTRFLPLRDL RQEGVRQVHG
TWFRLSFVYN HYLFFACILV VLLAIILYLL RLRRIHHRQT RASAPLNLLW IEEVVPMIGA
EVGP
//