ID F1S995_PIG Unreviewed; 1237 AA.
AC F1S995;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2022, sequence version 4.
DT 27-MAR-2024, entry version 74.
DE SubName: Full=Pleckstrin homology domain containing A7 {ECO:0000313|Ensembl:ENSSSCP00000014221.4};
GN Name=PLEKHA7 {ECO:0000313|Ensembl:ENSSSCP00000014221.4,
GN ECO:0000313|VGNC:VGNC:91537};
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00000014221.4, ECO:0000313|Proteomes:UP000008227};
RN [1] {ECO:0000313|Ensembl:ENSSSCP00000014221.4, ECO:0000313|Proteomes:UP000008227}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000014221.4,
RC ECO:0000313|Proteomes:UP000008227};
RG Porcine genome sequencing project;
RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSSCP00000014221.4}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; F1S995; -.
DR PeptideAtlas; F1S995; -.
DR Ensembl; ENSSSCT00000014616.5; ENSSSCP00000014221.4; ENSSSCG00000013382.5.
DR VGNC; VGNC:91537; PLEKHA7.
DR GeneTree; ENSGT00940000155817; -.
DR HOGENOM; CLU_008216_1_0_1; -.
DR TreeFam; TF329090; -.
DR Proteomes; UP000008227; Chromosome 2.
DR Bgee; ENSSSCG00000013382; Expressed in oocyte and 45 other cell types or tissues.
DR ExpressionAtlas; F1S995; baseline and differential.
DR CDD; cd13248; PH_PEPP1_2_3; 1.
DR CDD; cd00890; Prefoldin; 1.
DR CDD; cd00201; WW; 1.
DR Gene3D; 2.20.70.10; -; 2.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR040392; PKHA4-7_PH.
DR InterPro; IPR001202; WW_dom.
DR InterPro; IPR036020; WW_dom_sf.
DR PANTHER; PTHR12752; PHOSPHOINOSITOL 3-PHOSPHATE-BINDING PROTEIN; 1.
DR PANTHER; PTHR12752:SF4; PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY A MEMBER 7; 1.
DR Pfam; PF00169; PH; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00456; WW; 2.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF51045; WW domain; 2.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS01159; WW_DOMAIN_1; 1.
DR PROSITE; PS50020; WW_DOMAIN_2; 2.
PE 1: Evidence at protein level;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Proteomics identification {ECO:0007829|PeptideAtlas:F1S995};
KW Reference proteome {ECO:0000313|Proteomes:UP000008227}.
FT DOMAIN 9..42
FT /note="WW"
FT /evidence="ECO:0000259|PROSITE:PS50020"
FT DOMAIN 54..87
FT /note="WW"
FT /evidence="ECO:0000259|PROSITE:PS50020"
FT DOMAIN 164..282
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 105..137
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 288..369
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 399..515
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 533..553
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 582..602
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 842..876
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 890..1028
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 705..739
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 771..798
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 110..132
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 313..365
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 447..484
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 499..515
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 586..600
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 844..873
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 922..942
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 950..973
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1237 AA; 139893 MW; EC0B550D8FF123DB CRC64;
MAAAAVGRDA LPEHWSYGVC RDGRVFFIND QLRCTTWLHP RTGEPVNSGH MIRSDLPRGW
EEGFTEEGAS YFIDHNQQTT AFRHPVSGQF SPENSEFILQ EEPNPHMSKQ ERNQRPSSMV
SETSTAGTTS TVEAKPGPKI IKSSSKVHSF GKRDQAIRRN LNVPVVVRGW LHKQDSSGMR
LWKRRWFVLA DYCLFYYKDS REEAVLGSIP LPSYVISPVA PEDRISRKYS FKAVHTGMRA
LIYNSSAGGS QAEQSGMRTY YFSADTQEDM NAWVRAMNQA AQVLSRSSLK RDMEKVERQA
VPQANHTESC RECGRVGPGH ARDCPHRGHE DSFGFERREQ EEDRYRSQRD PLEGKRDRSK
ARSPYSPAED DALFVDLPSG PRGQQAQPQR AERNGVLPAA SGPGEQNGTG GYQRAFPPRT
NLEKHSQRKS NLAQVEQWAK AQKGDSRSLP LDQTLPRQGP SQSLPFPENY QTLPKSNRHP
SGGSSPPPRN LPSDYKYAQD RASHLKMSSE ERRAHRDGTV WQLYEWQQRQ QFRHGSPTAP
IGTGSPEFTD QGRSRSMLEV PRSISVPPSP SDIPPPGPPR VFPPRRPHTP AERVTVKPPD
QRRSVDISLG GSPRKAWGHT TKNSSHVDRR SMPSMGYMTH TVSAPSLHGK SADDTYLQLK
KDLEYLDLKM TGRDLLKDRS LKPVKIAESD IDVKLSVFCE QDRILQDLED KIRALKENKD
QLESVLEVLH RQMEQYRDQP QHLEKIAYQQ RLLQEDLVHI RAELSRESTE MENAWNEYLK
LERDVEQLKQ TLQEQHSRAF FFQEKSQIQK DLWRIEDVIA GLSANKENFR ILVESVKNPE
RKTVPLLPHP PVPSLSTPES KPPPPPSPPT SPTRTPLEVR LFPQLQTYVP YRPHPPQLRK
VTSPLQSPTK TKPKVEDEAP PRPPLPELYS PEDQPPAVPP LPREATIIRH TSVRGLKRQS
DERKRDREQG QCVNGDSRVE LRSYVSEPEL ATFSGDMAPP SLGLVGPESR YQTLPGRGLS
GSTSRLQQSS TIAPYVTLRR GLDAESSKVT YAWKREQDFD LQLLERAVQG DRKDKEENGW
LKVQAMPVTE LDLEPQDYDV DISRELSKPE KVSIPERYVE LDPEEPPSLE ELQARYRKAE
KIRNILARSS MCNLQPTSSQ DRDSVADLDS QLQEQERIIN ISYALASEAS QRSKQVAGEV
LVGRGSLRGR PHPCSLGLGP SMACQGVRGK ASVKLGC
//
