ID F1SAB0_PIG Unreviewed; 531 AA.
AC F1SAB0;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 3.
DT 27-MAR-2024, entry version 76.
DE SubName: Full=Cell division cycle 73 {ECO:0000313|Ensembl:ENSSSCP00000011514.3};
DE SubName: Full=Parafibromin {ECO:0000313|EMBL:HDB78040.1};
GN Name=CDC73 {ECO:0000313|Ensembl:ENSSSCP00000011514.3,
GN ECO:0000313|VGNC:VGNC:95817};
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00000011514.3, ECO:0000313|Proteomes:UP000008227};
RN [1] {ECO:0000313|Ensembl:ENSSSCP00000011514.3, ECO:0000313|Proteomes:UP000008227}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000011514.3,
RC ECO:0000313|Proteomes:UP000008227};
RG Porcine genome sequencing project;
RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:HDB78040.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=30723633; DOI=.7717/peerj.6374;
RA Gilbert D.G.;
RT "Genes of the pig, Sus scrofa, reconstructed with EvidentialGene.";
RL PeerJ 7:E6374-E6374(2019).
RN [3] {ECO:0000313|Ensembl:ENSSSCP00000011514.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the CDC73 family.
CC {ECO:0000256|ARBA:ARBA00010427}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; DQIR01222563; HDB78040.1; -; Transcribed_RNA.
DR STRING; 9823.ENSSSCP00000011514; -.
DR PaxDb; 9823-ENSSSCP00000011514; -.
DR Ensembl; ENSSSCT00000011817.5; ENSSSCP00000011514.3; ENSSSCG00000010801.5.
DR VGNC; VGNC:95817; CDC73.
DR eggNOG; KOG3786; Eukaryota.
DR GeneTree; ENSGT00390000001114; -.
DR HOGENOM; CLU_061264_0_0_1; -.
DR OMA; CAFHLKY; -.
DR OrthoDB; 180759at2759; -.
DR TreeFam; TF313016; -.
DR Reactome; R-SSC-112382; Formation of RNA Pol II elongation complex.
DR Reactome; R-SSC-201722; Formation of the beta-catenin:TCF transactivating complex.
DR Reactome; R-SSC-5632684; Hedgehog 'on' state.
DR Reactome; R-SSC-674695; RNA Polymerase II Pre-transcription Events.
DR Reactome; R-SSC-75955; RNA Polymerase II Transcription Elongation.
DR Reactome; R-SSC-8866654; E3 ubiquitin ligases ubiquitinate target proteins.
DR Proteomes; UP000008227; Chromosome 10.
DR Bgee; ENSSSCG00000010801; Expressed in epididymis and 46 other cell types or tissues.
DR GO; GO:0016593; C:Cdc73/Paf1 complex; IBA:GO_Central.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0000993; F:RNA polymerase II complex binding; IBA:GO_Central.
DR GO; GO:0050680; P:negative regulation of epithelial cell proliferation; IEA:Ensembl.
DR GO; GO:0048147; P:negative regulation of fibroblast proliferation; IEA:Ensembl.
DR GO; GO:2000134; P:negative regulation of G1/S transition of mitotic cell cycle; IEA:Ensembl.
DR GO; GO:0045638; P:negative regulation of myeloid cell differentiation; IEA:Ensembl.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR GO; GO:1902808; P:positive regulation of cell cycle G1/S phase transition; IEA:Ensembl.
DR GO; GO:0031442; P:positive regulation of mRNA 3'-end processing; IEA:Ensembl.
DR GO; GO:0032968; P:positive regulation of transcription elongation by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0030177; P:positive regulation of Wnt signaling pathway; IEA:Ensembl.
DR GO; GO:0031648; P:protein destabilization; IEA:Ensembl.
DR GO; GO:0034402; P:recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex; IBA:GO_Central.
DR GO; GO:0006368; P:transcription elongation by RNA polymerase II; IEA:Ensembl.
DR Gene3D; 3.40.50.11990; RNA polymerase II accessory factor, Cdc73 C-terminal domain; 1.
DR InterPro; IPR007852; Cdc73/Parafibromin.
DR InterPro; IPR031336; CDC73_C.
DR InterPro; IPR038103; CDC73_C_sf.
DR InterPro; IPR032041; Cdc73_N.
DR PANTHER; PTHR12466; CDC73 DOMAIN PROTEIN; 1.
DR PANTHER; PTHR12466:SF8; PARAFIBROMIN; 1.
DR Pfam; PF05179; CDC73_C; 1.
DR Pfam; PF16050; CDC73_N; 1.
PE 1: Evidence at protein level;
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Proteomics identification {ECO:0007829|PeptideAtlas:F1SAB0};
KW Reference proteome {ECO:0000313|Proteomes:UP000008227};
KW Transcription {ECO:0000256|ARBA:ARBA00023163}.
FT DOMAIN 1..297
FT /note="Paf1 complex subunit Cdc73 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF16050"
FT DOMAIN 357..520
FT /note="Cell division control protein 73 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF05179"
FT REGION 260..292
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 325..358
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 325..340
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 531 AA; 60577 MW; 894A7448DBC0E793 CRC64;
MADVLSVLRQ YNIQKKEIVV KGDEVIFGEF SWPKNVKTNY VVWGTGKEGQ PREYYTLDSI
LFLLNNVHLS HPVYVRRAAT ENIPVVRRPD RKDLLGYLNG EASTSASIDR SAPLEIGLQR
STQVKRAADE VLAEAKKPRI EDEECVRLDK ERLAARLEGH KEGIVQTEQI RSLSEAMSVE
KIAAIKAKIM AKKRSTIKTD LDDDITALKQ RSFVDAEVDV TRDIVSRERV WRTRTTILQS
TGKNFSKNIF AILQSVKARE EGRAPEQRPA PNAAPVDPTL RTKQPIPAAY NRYDQERFKG
KEETEGFKID TMGTYHGMTL KSVTEGASAR KTQTPAAQPV PRPVSQARPP PNQKKGSRTP
IIIIPAATTS LITMLNAKDL LQDLKFVPSD EKKKQGCQRE NETLIQRRKD QMQPGGTAIS
VTVPYRVVDQ PLKLMPQDWD RVVAVFVQGP AWQFKGWPWL LPDGSPVDIF AKIKAFHLKY
DEVRLDPNVQ KWDVTVLELS YHKRHLDRPV FLRFWETLDR YMVKHKSHLR F
//
