ID   F1SDK7_PIG              Unreviewed;       312 AA.
AC   F1SDK7;
DT   03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT   11-DEC-2019, sequence version 3.
DT   27-MAR-2024, entry version 84.
DE   SubName: Full=Forkhead box I2 {ECO:0000313|Ensembl:ENSSSCP00000011462.3};
GN   Name=FOXI2 {ECO:0000313|Ensembl:ENSSSCP00000011462.3,
GN   ECO:0000313|VGNC:VGNC:88209};
OS   Sus scrofa (Pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX   NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00000011462.3, ECO:0000313|Proteomes:UP000008227};
RN   [1] {ECO:0000313|Ensembl:ENSSSCP00000011462.3, ECO:0000313|Proteomes:UP000008227}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000011462.3,
RC   ECO:0000313|Proteomes:UP000008227};
RG   Porcine genome sequencing project;
RL   Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSSSCP00000011462.3}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC       ECO:0000256|PROSITE-ProRule:PRU00089}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   RefSeq; XP_001928269.4; XM_001928234.4.
DR   AlphaFoldDB; F1SDK7; -.
DR   SMR; F1SDK7; -.
DR   STRING; 9823.ENSSSCP00000011462; -.
DR   PaxDb; 9823-ENSSSCP00000011462; -.
DR   Ensembl; ENSSSCT00000011764.4; ENSSSCP00000011462.3; ENSSSCG00000010752.4.
DR   GeneID; 100157475; -.
DR   KEGG; ssc:100157475; -.
DR   CTD; 399823; -.
DR   VGNC; VGNC:88209; FOXI2.
DR   eggNOG; KOG2294; Eukaryota.
DR   GeneTree; ENSGT00940000161176; -.
DR   HOGENOM; CLU_046860_1_0_1; -.
DR   InParanoid; F1SDK7; -.
DR   OrthoDB; 5385885at2759; -.
DR   TreeFam; TF316127; -.
DR   Proteomes; UP000008227; Chromosome 14.
DR   Bgee; ENSSSCG00000010752; Expressed in forelimb bud and 2 other cell types or tissues.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0009653; P:anatomical structure morphogenesis; IBA:GO_Central.
DR   GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd20053; FH_FOXI1; 1.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   InterPro; IPR001766; Fork_head_dom.
DR   InterPro; IPR018122; TF_fork_head_CS_1.
DR   InterPro; IPR030456; TF_fork_head_CS_2.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR11829; FORKHEAD BOX PROTEIN; 1.
DR   PANTHER; PTHR11829:SF372; FORKHEAD BOX PROTEIN I2; 1.
DR   Pfam; PF00250; Forkhead; 1.
DR   PRINTS; PR00053; FORKHEAD.
DR   SMART; SM00339; FH; 1.
DR   SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR   PROSITE; PS00657; FORK_HEAD_1; 1.
DR   PROSITE; PS00658; FORK_HEAD_2; 1.
DR   PROSITE; PS50039; FORK_HEAD_3; 1.
PE   4: Predicted;
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW   ProRule:PRU00089}; Nucleus {ECO:0000256|PROSITE-ProRule:PRU00089};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008227}.
FT   DOMAIN          97..191
FT                   /note="Fork-head"
FT                   /evidence="ECO:0000259|PROSITE:PS50039"
FT   DNA_BIND        97..191
FT                   /note="Fork-head"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00089"
FT   REGION          188..210
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   312 AA;  32350 MW;  D5E7C928545D9018 CRC64;
     MASYCDGSGR CQAPHSQTRA AAHPAGYARG DLGAAGGGPR LWLNAPALSS VPYAPGPGST
     SPYGAPGPLL GVPGGLVGAD LAWLSLSGQQ ELLRLVRPPY SYSALIAMAI QSAPLRKLTL
     SQIYQYVAGN FPFYKRSKAG WQNSIRHNLS LNDCFKKVPR DEDDPGKGNY WTLDPNCEKM
     FDNGNFRRKR KRRGEASTAA PSGARSPGGA KARELEALGA ASPDLQAASS PPASDAAACF
     SSFASAMGAL AGGLGTLPGG LAGDFSFGRS TTVTAQGPQF PGPAPGFPAG HQTATTSFRP
     GRFVYSQEGT EV
//