ID   F1SHC0_PIG              Unreviewed;       469 AA.
AC   F1SHC0;
DT   03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 3.
DT   27-MAR-2024, entry version 80.
DE   SubName: Full=Peripherin {ECO:0000313|Ensembl:ENSSSCP00000000206.3};
GN   Name=PRPH {ECO:0000313|Ensembl:ENSSSCP00000000206.3,
GN   ECO:0000313|VGNC:VGNC:91847};
OS   Sus scrofa (Pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX   NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00000000206.3, ECO:0000313|Proteomes:UP000008227};
RN   [1] {ECO:0000313|Ensembl:ENSSSCP00000000206.3, ECO:0000313|Proteomes:UP000008227}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000000206.3,
RC   ECO:0000313|Proteomes:UP000008227};
RG   Porcine genome sequencing project;
RL   Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSSSCP00000000206.3}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the intermediate filament family.
CC       {ECO:0000256|RuleBase:RU000685}.
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DR   RefSeq; XP_003126153.1; XM_003126105.3.
DR   AlphaFoldDB; F1SHC0; -.
DR   PaxDb; 9823-ENSSSCP00000000206; -.
DR   PeptideAtlas; F1SHC0; -.
DR   Ensembl; ENSSSCT00000000208.4; ENSSSCP00000000206.3; ENSSSCG00000000195.5.
DR   GeneID; 100152434; -.
DR   KEGG; ssc:100152434; -.
DR   CTD; 5630; -.
DR   VGNC; VGNC:91847; PRPH.
DR   eggNOG; ENOG502QPSH; Eukaryota.
DR   GeneTree; ENSGT00940000160203; -.
DR   HOGENOM; CLU_012560_7_4_1; -.
DR   OMA; THSRKMV; -.
DR   OrthoDB; 4640531at2759; -.
DR   TreeFam; TF330122; -.
DR   Proteomes; UP000008227; Chromosome 5.
DR   Bgee; ENSSSCG00000000195; Expressed in pons and 15 other cell types or tissues.
DR   ExpressionAtlas; F1SHC0; baseline.
DR   GO; GO:0005882; C:intermediate filament; IEA:UniProtKB-KW.
DR   GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR   Gene3D; 1.20.5.170; -; 1.
DR   Gene3D; 1.20.5.500; Single helix bin; 1.
DR   Gene3D; 1.20.5.1160; Vasodilator-stimulated phosphoprotein; 1.
DR   InterPro; IPR018039; IF_conserved.
DR   InterPro; IPR039008; IF_rod_dom.
DR   InterPro; IPR006821; Intermed_filament_DNA-bd.
DR   InterPro; IPR002957; Keratin_I.
DR   PANTHER; PTHR45652; GLIAL FIBRILLARY ACIDIC PROTEIN; 1.
DR   PANTHER; PTHR45652:SF14; PERIPHERIN; 1.
DR   Pfam; PF00038; Filament; 1.
DR   Pfam; PF04732; Filament_head; 1.
DR   PRINTS; PR01248; TYPE1KERATIN.
DR   SMART; SM01391; Filament; 1.
DR   SUPFAM; SSF64593; Intermediate filament protein, coiled coil region; 2.
DR   PROSITE; PS00226; IF_ROD_1; 1.
DR   PROSITE; PS51842; IF_ROD_2; 1.
PE   1: Evidence at protein level;
KW   Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW   Intermediate filament {ECO:0000256|ARBA:ARBA00022754,
KW   ECO:0000256|RuleBase:RU000685};
KW   Proteomics identification {ECO:0007829|PeptideAtlas:F1SHC0};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008227}.
FT   DOMAIN          96..406
FT                   /note="IF rod"
FT                   /evidence="ECO:0000259|PROSITE:PS51842"
FT   REGION          1..58
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          447..469
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          86..248
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          293..384
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        1..21
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        28..54
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   469 AA;  53594 MW;  EF6DF1A392CCE4E1 CRC64;
     MSHPSGLRSS VSSTSYRRTF GPPPSLSPGA FSYSSSSRFS SSRLLGSASP GSSVRLGSFR
     GPRAGAGSLL RLPSERLDFS MAEALNQEFL ATRSNEKQEL QELNDRFANF IEKVRFLEQQ
     NAALRGELSQ ARGQEPARAD QLCQQELREL RRELELLGRE RDRVQVERDG LAEDLAALKQ
     RLEEETRKRE DAEHNLVLFR KDVDDATLSR LELERKIESL MDEIEFLKKL HEEELRDLQM
     SVESQQVQQF EVEATVKPEL TAALRDIRAQ YESIAAKNLQ EAEEWYKSKY ADLSDAANRN
     HEALRQAKQE MNESRRQIQS LTCEVDGLRG TNEALLRQLR ELEEQFALEA GGYQAGAAKL
     EEELRQLKEE MARHLREYQE LLNVKMALDI EIATYRKLLE GEESRISVPV HSFASLSIKT
     TVPEVEPPQE IHSRKMVLIK TIETRDGEVV TESQKEQRSE LDKSSTHSY
//