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Database: UniProt
Entry: F1SI56_PIG
LinkDB: F1SI56_PIG
Original site: F1SI56_PIG 
ID   F1SI56_PIG              Unreviewed;       717 AA.
AC   F1SI56;
DT   03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 2.
DT   10-OCT-2018, entry version 44.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSSSCP00000005079};
GN   Name=TGM5 {ECO:0000313|Ensembl:ENSSSCP00000005079};
OS   Sus scrofa (Pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Suina; Suidae;
OC   Sus.
OX   NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00000005079, ECO:0000313|Proteomes:UP000008227};
RN   [1] {ECO:0000313|Ensembl:ENSSSCP00000005079, ECO:0000313|Proteomes:UP000008227}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000005079};
RG   Porcine genome sequencing project;
RL   Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSSSCP00000005079}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (MAY-2011) to UniProtKB.
CC   -!- COFACTOR:
CC       Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
CC         Evidence={ECO:0000256|PIRSR:PIRSR000459-2};
CC       Note=Binds 1 Ca(2+) ion per subunit.
CC       {ECO:0000256|PIRSR:PIRSR000459-2};
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DR   EMBL; AEMK02000004; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 9823.ENSSSCP00000005079; -.
DR   PaxDb; F1SI56; -.
DR   PeptideAtlas; F1SI56; -.
DR   PRIDE; F1SI56; -.
DR   Ensembl; ENSSSCT00000005205; ENSSSCP00000005079; ENSSSCG00000004713.
DR   eggNOG; ENOG410IFMV; Eukaryota.
DR   eggNOG; ENOG410XQEZ; LUCA.
DR   GeneTree; ENSGT00760000119108; -.
DR   InParanoid; F1SI56; -.
DR   OrthoDB; EOG091G030K; -.
DR   TreeFam; TF324278; -.
DR   Reactome; R-SSC-6809371; Formation of the cornified envelope.
DR   Proteomes; UP000008227; Chromosome 1.
DR   Bgee; ENSSSCG00000004713; Expressed in 2 organ(s), highest expression level in heart.
DR   ExpressionAtlas; F1SI56; baseline.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0003810; F:protein-glutamine gamma-glutamyltransferase activity; IEA:InterPro.
DR   GO; GO:0018149; P:peptide cross-linking; IEA:InterPro.
DR   Gene3D; 2.60.40.10; -; 3.
DR   Gene3D; 3.90.260.10; -; 1.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR014756; Ig_E-set.
DR   InterPro; IPR038765; Papain_like_cys_pep_sf.
DR   InterPro; IPR002931; Transglutaminase-like.
DR   InterPro; IPR036985; Transglutaminase-like_sf.
DR   InterPro; IPR023608; Transglutaminase_animal.
DR   InterPro; IPR013808; Transglutaminase_AS.
DR   InterPro; IPR008958; Transglutaminase_C.
DR   InterPro; IPR036238; Transglutaminase_C_sf.
DR   InterPro; IPR001102; Transglutaminase_N.
DR   Pfam; PF00927; Transglut_C; 2.
DR   Pfam; PF01841; Transglut_core; 1.
DR   Pfam; PF00868; Transglut_N; 1.
DR   PIRSF; PIRSF000459; TGM_EBP42; 1.
DR   SMART; SM00460; TGc; 1.
DR   SUPFAM; SSF49309; SSF49309; 2.
DR   SUPFAM; SSF54001; SSF54001; 1.
DR   SUPFAM; SSF81296; SSF81296; 1.
DR   PROSITE; PS00547; TRANSGLUTAMINASES; 1.
PE   4: Predicted;
KW   Calcium {ECO:0000256|PIRSR:PIRSR000459-2};
KW   Complete proteome {ECO:0000313|Proteomes:UP000008227};
KW   Metal-binding {ECO:0000256|PIRSR:PIRSR000459-2};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008227}.
FT   DOMAIN      269    362       TGc. {ECO:0000259|SMART:SM00460}.
FT   ACT_SITE    277    277       {ECO:0000256|PIRSR:PIRSR000459-1}.
FT   ACT_SITE    336    336       {ECO:0000256|PIRSR:PIRSR000459-1}.
FT   ACT_SITE    359    359       {ECO:0000256|PIRSR:PIRSR000459-1}.
FT   METAL       399    399       Calcium. {ECO:0000256|PIRSR:PIRSR000459-
FT                                2}.
FT   METAL       401    401       Calcium. {ECO:0000256|PIRSR:PIRSR000459-
FT                                2}.
FT   METAL       447    447       Calcium. {ECO:0000256|PIRSR:PIRSR000459-
FT                                2}.
FT   METAL       452    452       Calcium. {ECO:0000256|PIRSR:PIRSR000459-
FT                                2}.
SQ   SEQUENCE   717 AA;  79924 MW;  2635C13F2C816312 CRC64;
     VAGLEVALID LQSSWNNVRH HTEEISSDRL LVRRGQAFII TLYFRNRAFQ PGLDNIIFVA
     DTGPLPDVAK GTRAVFSLAG HGGPSPWMAS LEATGAASME VSLCAPPMAA VGRYLLKVHI
     ESLQGPVTAY QLGEFILLFN PWCPEDAVYL DSEPQRQEYV VNDYGFIYQG NKNWIRPCPW
     NYGQFEENII DICLELLAKS LNFQIDPATD CALRGSPVYI SRVVCAMINS NDDNGVLNGN
     WSENYLDGIN PAEWTGSVAI LKQWHATGCQ PVRYGQCWVF AAVMCTVMRC LGIPTRVITN
     FDSGHDTDGN LIIDEYYDNT GRILENKKKD TVWNFHVWNE CWMARRDLPE GYGGWQVLDA
     TPQETSNGLY CCGPASVRAI KEGEVDLNYD TAFAFSMVNA DCMSWLVFRG KEQKLHQDTS
     SVGNFISTKG IQSNERDDIT ENYKYGEGSP QERQVFLKAL QKLKAGGSQG SLREDLQPSG
     SLPLRDSPRS LATPSLRPSD VVQVSLKFQL LDPPDMGRDI RFVLLALNMS LQFKDLRVNL
     SAQSLLHDGS PLPPFWQDTA FLTLAPEEAK THSCKIPYSQ YSQYLSTDKL IRISALGEEK
     NSPEKILVNK IITLAYPSIM INVLGAAIVN QPLSIQVIFS NPLSEPVADC VLTVEGSGLF
     RKQQRVLIGV LKPQHRASLT LETVPFKSGQ RQIQANLRSD KFKDIKGYKN IYVDLGL
//
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