ID   F1SI59_PIG              Unreviewed;       355 AA.
AC   F1SI59;
DT   03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT   11-JUL-2012, sequence version 2.
DT   27-MAR-2024, entry version 76.
DE   SubName: Full=Adenosine deaminase like {ECO:0000313|Ensembl:ENSSSCP00000005076.2};
DE   SubName: Full=Adenosine deaminase-like protein isoform X1 {ECO:0000313|EMBL:HDA54867.1};
GN   Name=ADAL {ECO:0000313|Ensembl:ENSSSCP00000005076.2,
GN   ECO:0000313|VGNC:VGNC:85060};
OS   Sus scrofa (Pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX   NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00000005076.2, ECO:0000313|Proteomes:UP000008227};
RN   [1] {ECO:0000313|Ensembl:ENSSSCP00000005076.2, ECO:0000313|Proteomes:UP000008227}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000005076.2,
RC   ECO:0000313|Proteomes:UP000008227};
RG   Porcine genome sequencing project;
RL   Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:HDA54867.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=30723633; DOI=.7717/peerj.6374;
RA   Gilbert D.G.;
RT   "Genes of the pig, Sus scrofa, reconstructed with EvidentialGene.";
RL   PeerJ 7:E6374-E6374(2019).
RN   [3] {ECO:0000313|Ensembl:ENSSSCP00000005076.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H(+) + H2O + N(6)-methyl-AMP = IMP + methylamine;
CC         Xref=Rhea:RHEA:16001, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:58053, ChEBI:CHEBI:59338, ChEBI:CHEBI:144842;
CC         Evidence={ECO:0000256|ARBA:ARBA00036622};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:16002;
CC         Evidence={ECO:0000256|ARBA:ARBA00036622};
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|ARBA:ARBA00001947};
CC   -!- SUBUNIT: Monomer. {ECO:0000256|ARBA:ARBA00011245}.
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DR   EMBL; DQIR01099391; HDA54867.1; -; Transcribed_RNA.
DR   RefSeq; XP_005659746.1; XM_005659689.2.
DR   STRING; 9823.ENSSSCP00000005076; -.
DR   PaxDb; 9823-ENSSSCP00000005076; -.
DR   Ensembl; ENSSSCT00000005202.5; ENSSSCP00000005076.2; ENSSSCG00000004710.5.
DR   GeneID; 100155388; -.
DR   KEGG; ssc:100155388; -.
DR   CTD; 161823; -.
DR   VGNC; VGNC:85060; ADAL.
DR   eggNOG; KOG1097; Eukaryota.
DR   GeneTree; ENSGT00950000183113; -.
DR   HOGENOM; CLU_039228_3_0_1; -.
DR   OMA; RPQFKPY; -.
DR   OrthoDB; 20281at2759; -.
DR   TreeFam; TF314270; -.
DR   Reactome; R-SSC-2161541; Abacavir metabolism.
DR   Reactome; R-SSC-74217; Purine salvage.
DR   Proteomes; UP000008227; Chromosome 1.
DR   Bgee; ENSSSCG00000004710; Expressed in pituitary gland and 44 other cell types or tissues.
DR   GO; GO:0004000; F:adenosine deaminase activity; IBA:GO_Central.
DR   GO; GO:0006154; P:adenosine catabolic process; IBA:GO_Central.
DR   GO; GO:0046103; P:inosine biosynthetic process; IBA:GO_Central.
DR   CDD; cd00443; ADA_AMPD; 1.
DR   Gene3D; 3.20.20.140; Metal-dependent hydrolases; 1.
DR   InterPro; IPR001365; A_deaminase_dom.
DR   InterPro; IPR006330; Ado/ade_deaminase.
DR   InterPro; IPR032466; Metal_Hydrolase.
DR   PANTHER; PTHR11409; ADENOSINE DEAMINASE; 1.
DR   PANTHER; PTHR11409:SF42; ADENOSINE DEAMINASE-LIKE PROTEIN; 1.
DR   Pfam; PF00962; A_deaminase; 1.
DR   SUPFAM; SSF51556; Metallo-dependent hydrolases; 1.
PE   1: Evidence at protein level;
KW   Proteomics identification {ECO:0007829|PeptideAtlas:F1SI59};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008227}.
FT   DOMAIN          19..344
FT                   /note="Adenosine deaminase"
FT                   /evidence="ECO:0000259|Pfam:PF00962"
SQ   SEQUENCE   355 AA;  40008 MW;  304C52CA236AE4C9 CRC64;
     MMEAEEQQSW KTTFYSKLPK VELHAHLNGS ISSNTIKKLI TKKPGLKIHD QMTMIDKGKK
     RTLEECFQMF PIIHQLTTSP EDILMVTKDV IKEFADDGVK YLELRSTPRG ENATGMTKKT
     YVESVLEGIK QSKQENVDID VRYLISIDRR GGPSAAKENV KLAEEFFLST EGIVLGLDLS
     GDPTAGQAKD FLEPLLEAKK SGLKLALHLS EIPNQEKETQ VLLDLLPDRI GHGTFLSCSD
     GGSPDLVDFV RQHQIPLELC LTSNIKSQTV PSYDQHHFGF WYSLVHPAVI CTDDKGVFAT
     HLSQEYQLAA ETFNLTQSQV WDLSYESISY IFASDSTKSA LRKKWNQMKP KALHF
//