ID F1SKI9_PIG Unreviewed; 497 AA.
AC F1SKI9; A0A480PUV5;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2022, sequence version 3.
DT 27-MAR-2024, entry version 77.
DE SubName: Full=Prolyl 4-hydroxylase, transmembrane {ECO:0000313|Ensembl:ENSSSCP00000012121.4};
DE SubName: Full=Transmembrane prolyl 4-hydroxylase isoform a {ECO:0000313|EMBL:HDB14156.1};
GN Name=P4HTM {ECO:0000313|Ensembl:ENSSSCP00000012121.4,
GN ECO:0000313|VGNC:VGNC:91136};
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00000012121.4, ECO:0000313|Proteomes:UP000008227};
RN [1] {ECO:0000313|Ensembl:ENSSSCP00000012121.4, ECO:0000313|Proteomes:UP000008227}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000012121.4,
RC ECO:0000313|Proteomes:UP000008227};
RG Porcine genome sequencing project;
RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:HDB14156.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=30723633; DOI=.7717/peerj.6374;
RA Gilbert D.G.;
RT "Genes of the pig, Sus scrofa, reconstructed with EvidentialGene.";
RL PeerJ 7:E6374-E6374(2019).
RN [3] {ECO:0000313|Ensembl:ENSSSCP00000012121.4}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- COFACTOR:
CC Name=L-ascorbate; Xref=ChEBI:CHEBI:38290;
CC Evidence={ECO:0000256|ARBA:ARBA00001961};
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DR EMBL; DQIR01158679; HDB14156.1; -; Transcribed_RNA.
DR RefSeq; XP_003132246.1; XM_003132198.3.
DR STRING; 9823.ENSSSCP00000012121; -.
DR PaxDb; 9823-ENSSSCP00000012121; -.
DR Ensembl; ENSSSCT00000012446.5; ENSSSCP00000012121.4; ENSSSCG00000011368.5.
DR GeneID; 110255176; -.
DR KEGG; ssc:110255176; -.
DR CTD; 54681; -.
DR VGNC; VGNC:91136; P4HTM.
DR eggNOG; KOG1591; Eukaryota.
DR GeneTree; ENSGT00390000014570; -.
DR HOGENOM; CLU_035319_0_0_1; -.
DR OMA; MTQAQPC; -.
DR OrthoDB; 5471701at2759; -.
DR TreeFam; TF332923; -.
DR Proteomes; UP000008227; Chromosome 13.
DR Bgee; ENSSSCG00000011368; Expressed in forelimb bud and 39 other cell types or tissues.
DR Genevisible; F1SKI9; SS.
DR GO; GO:0005783; C:endoplasmic reticulum; IBA:GO_Central.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR GO; GO:0031418; F:L-ascorbic acid binding; IEA:InterPro.
DR GO; GO:0004656; F:procollagen-proline 4-dioxygenase activity; IBA:GO_Central.
DR GO; GO:0045646; P:regulation of erythrocyte differentiation; IEA:Ensembl.
DR CDD; cd00051; EFh; 1.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR Gene3D; 2.60.120.620; q2cbj1_9rhob like domain; 1.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR005123; Oxoglu/Fe-dep_dioxygenase.
DR InterPro; IPR045054; P4HA-like.
DR InterPro; IPR006620; Pro_4_hyd_alph.
DR InterPro; IPR044862; Pro_4_hyd_alph_FE2OG_OXY.
DR PANTHER; PTHR10869; PROLYL 4-HYDROXYLASE ALPHA SUBUNIT; 1.
DR PANTHER; PTHR10869:SF230; TRANSMEMBRANE PROLYL 4-HYDROXYLASE; 1.
DR Pfam; PF13640; 2OG-FeII_Oxy_3; 1.
DR Pfam; PF13499; EF-hand_7; 1.
DR SMART; SM00702; P4Hc; 1.
DR SUPFAM; SSF47473; EF-hand; 1.
DR PROSITE; PS00018; EF_HAND_1; 2.
DR PROSITE; PS51471; FE2OG_OXY; 1.
PE 1: Evidence at protein level;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Dioxygenase {ECO:0000256|ARBA:ARBA00022964};
KW Iron {ECO:0000256|ARBA:ARBA00023004}; Membrane {ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Proteomics identification {ECO:0007829|PeptideAtlas:F1SKI9};
KW Reference proteome {ECO:0000313|Proteomes:UP000008227};
KW Transmembrane {ECO:0000256|SAM:Phobius, ECO:0000313|EMBL:HDB14156.1};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 54..79
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 305..455
FT /note="Fe2OG dioxygenase"
FT /evidence="ECO:0000259|PROSITE:PS51471"
FT REGION 1..36
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 84..106
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 84..101
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 497 AA; 56038 MW; B4FA08B088AD6BB5 CRC64;
MAAAAAAAGP RREDSSPQWT PPPREPVGAA AGLGDCEDAP VRPLGKPRGI CSRAYFLVLM
VFVHLYLGNV LALLLFVHYS NGDESSDPGP QRRTQSPGPA PTLAPLTRLE GIKVGHERKV
QLVADRDHFI RTLSLKPLLF EVPGFLSDEE CRLIIHLAQM KGLQRSQILP TEEYEEAMGT
MQISQLDLFQ LLDQNHDGHL QLREVLAQTR LGNGRWMTPE NIQEMYSAIK ADPDGDGVLS
LQEFSDMDLR DFHKYMRSHK AESSELVRNS YHTWLYQGEG AHHVMRAIRQ RVLRLTRLSP
EIVELSEPLQ VVRYGEGGHY HAHVDSGPVY PETICSHTKL VANESVPFET SCRYMTVLFY
LNNVTGGGET VFPVADNRTY DEMSLIQDDI DLRDTRRHCD KGNLRVKPRQ GTAVFWYNYL
PDGQGWVGDV DDYSLHGGCL VTRGTKWIAN NWINVDPSRA RQALFQQEMA RLAREGGADS
QPEWALDRAY RNARVEL
//
