ID F1SKK3_PIG Unreviewed; 715 AA.
AC F1SKK3;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 4.
DT 27-MAR-2024, entry version 79.
DE SubName: Full=NCK interacting protein with SH3 domain {ECO:0000313|Ensembl:ENSSSCP00000012117.4};
GN Name=NCKIPSD {ECO:0000313|Ensembl:ENSSSCP00000012117.4,
GN ECO:0000313|VGNC:VGNC:90612};
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00000012117.4, ECO:0000313|Proteomes:UP000008227};
RN [1] {ECO:0000313|Ensembl:ENSSSCP00000012117.4, ECO:0000313|Proteomes:UP000008227}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000012117.4,
RC ECO:0000313|Proteomes:UP000008227};
RG Porcine genome sequencing project;
RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSSCP00000012117.4}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; F1SKK3; -.
DR SMR; F1SKK3; -.
DR STRING; 9823.ENSSSCP00000012117; -.
DR PeptideAtlas; F1SKK3; -.
DR Ensembl; ENSSSCT00000012442.5; ENSSSCP00000012117.4; ENSSSCG00000011364.5.
DR VGNC; VGNC:90612; NCKIPSD.
DR eggNOG; KOG4035; Eukaryota.
DR GeneTree; ENSGT00390000015725; -.
DR HOGENOM; CLU_012978_1_0_1; -.
DR InParanoid; F1SKK3; -.
DR TreeFam; TF324522; -.
DR Reactome; R-SSC-2029482; Regulation of actin dynamics for phagocytic cup formation.
DR Reactome; R-SSC-5663213; RHO GTPases Activate WASPs and WAVEs.
DR Proteomes; UP000008227; Chromosome 13.
DR Bgee; ENSSSCG00000011364; Expressed in prefrontal cortex and 43 other cell types or tissues.
DR ExpressionAtlas; F1SKK3; baseline and differential.
DR GO; GO:0071933; F:Arp2/3 complex binding; IBA:GO_Central.
DR GO; GO:0006897; P:endocytosis; IBA:GO_Central.
DR InterPro; IPR030125; SPIN90/Ldb17.
DR InterPro; IPR018556; SPIN90/Ldb17_LRD.
DR PANTHER; PTHR13357:SF1; NCK-INTERACTING PROTEIN WITH SH3 DOMAIN; 1.
DR PANTHER; PTHR13357; SH3 ADAPTER PROTEIN SPIN90 NCK INTERACTING PROTEIN WITH SH3 DOMAIN; 1.
DR Pfam; PF09431; SPIN90_LRD; 1.
PE 1: Evidence at protein level;
KW Proteomics identification {ECO:0007829|PeptideAtlas:F1SKK3};
KW Reference proteome {ECO:0000313|Proteomes:UP000008227}.
FT DOMAIN 541..675
FT /note="SPIN90/Ldb17 leucine-rich"
FT /evidence="ECO:0000259|Pfam:PF09431"
FT REGION 1..58
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 102..125
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 150..273
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 192..231
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 715 AA; 78016 MW; A0E978EDB42682EF CRC64;
MSRGKASAAR RSWPGVLNPQ TSPSLLPRPA PAQPGPSPCT ARCTRSARRS PTRWRSPRAR
PSWCWSAAAR TGGWRRGRAV ARRATCRPPT CAACRKLIHH RKETLSRRGP SAPSPAAMTS
STSDHHLDTA AARQPNGVCR AGFERQHSLP SSEYLGADGG LYQIPPQPRR AAPTTPPPPV
KRRDREALVA SGSGGCNTTP SGGSSVSSGS SVSSTSLDTY YTGSSSSELG PSCSPTPPPV
PRRSTHTTVS QAQPPPSKVP NPEPPAEEVA VDTASAPDEL EALGTLSLGT TEEKAAAETA
VPRTIGAELM ELVRRNTGLS HELCRVAIGV VVGHIQASVP ASSPVMEQVL LSLVEGKDLS
TALPSGQVCH DQQRLEVIFA DLARRKDDAQ QRSWALYEDE GVIRCYLEEL LHILTDADPE
VCKKMCKRNE FESVLALVAY YQMEHRVSLR LLLLKCFGAM CSLDAAIIST LVSSVLPVEL
ARDMQTDTQD HQKLCYSALI LAMIFSMGEA VPYAHYEHLG TPFAQFLLSI VEDGLPLDTT
EQLPDLCMNL LLALNLHLPA PDQNIIMAAL SKHANVKIFS EKLLLLLNRG DDPVRIFKHE
PQPPHSILKF LQDVFASPAT AAIFYHTDMM ALIDITVRHI ADLSPGDKLR MEYLSLMHAV
VRSTPYLQHR HRLPDLQATL RRILTEEEAS PQCQMDRMIV REMCKEFPVL GEAPS
//
