ID F1SM67_PIG Unreviewed; 779 AA.
AC F1SM67;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 3.
DT 27-MAR-2024, entry version 85.
DE SubName: Full=Centromere/kinetochore protein zw10 homolog {ECO:0000313|EMBL:HDA54439.1};
DE SubName: Full=Zw10 kinetochore protein {ECO:0000313|Ensembl:ENSSSCP00000015975.3};
GN Name=ZW10 {ECO:0000313|Ensembl:ENSSSCP00000015975.3,
GN ECO:0000313|VGNC:VGNC:95340};
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00000015975.3, ECO:0000313|Proteomes:UP000008227};
RN [1] {ECO:0000313|Ensembl:ENSSSCP00000015975.3, ECO:0000313|Proteomes:UP000008227}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000015975.3,
RC ECO:0000313|Proteomes:UP000008227};
RG Porcine genome sequencing project;
RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:HDA54439.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=30723633; DOI=.7717/peerj.6374;
RA Gilbert D.G.;
RT "Genes of the pig, Sus scrofa, reconstructed with EvidentialGene.";
RL PeerJ 7:E6374-E6374(2019).
RN [3] {ECO:0000313|Ensembl:ENSSSCP00000015975.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Chromosome, centromere, kinetochore
CC {ECO:0000256|ARBA:ARBA00004629}.
CC -!- SIMILARITY: Belongs to the ZW10 family.
CC {ECO:0000256|ARBA:ARBA00006245}.
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DR EMBL; DQIR01098963; HDA54439.1; -; Transcribed_RNA.
DR RefSeq; XP_013834865.1; XM_013979411.1.
DR STRING; 9823.ENSSSCP00000015975; -.
DR PaxDb; 9823-ENSSSCP00000015975; -.
DR Ensembl; ENSSSCT00000016416.5; ENSSSCP00000015975.3; ENSSSCG00000015050.5.
DR VGNC; VGNC:95340; ZW10.
DR eggNOG; KOG2163; Eukaryota.
DR GeneTree; ENSGT00390000016427; -.
DR HOGENOM; CLU_012948_0_0_1; -.
DR OMA; TWPRMSE; -.
DR OrthoDB; 2786073at2759; -.
DR TreeFam; TF105966; -.
DR Reactome; R-SSC-141444; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal.
DR Reactome; R-SSC-2467813; Separation of Sister Chromatids.
DR Reactome; R-SSC-2500257; Resolution of Sister Chromatid Cohesion.
DR Reactome; R-SSC-5663220; RHO GTPases Activate Formins.
DR Reactome; R-SSC-6811434; COPI-dependent Golgi-to-ER retrograde traffic.
DR Reactome; R-SSC-68877; Mitotic Prometaphase.
DR Reactome; R-SSC-9648025; EML4 and NUDC in mitotic spindle formation.
DR Proteomes; UP000008227; Chromosome 9.
DR Bgee; ENSSSCG00000015050; Expressed in pituitary gland and 45 other cell types or tissues.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0070939; C:Dsl1/NZR complex; IEA:Ensembl.
DR GO; GO:0005828; C:kinetochore microtubule; IEA:Ensembl.
DR GO; GO:0005811; C:lipid droplet; IEA:Ensembl.
DR GO; GO:0005634; C:nucleus; IEA:Ensembl.
DR GO; GO:1990423; C:RZZ complex; IBA:GO_Central.
DR GO; GO:0000922; C:spindle pole; IEA:Ensembl.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0006888; P:endoplasmic reticulum to Golgi vesicle-mediated transport; IBA:GO_Central.
DR GO; GO:0000132; P:establishment of mitotic spindle orientation; IEA:Ensembl.
DR GO; GO:0007030; P:Golgi organization; IEA:Ensembl.
DR GO; GO:0007080; P:mitotic metaphase chromosome alignment; IEA:Ensembl.
DR GO; GO:0007094; P:mitotic spindle assembly checkpoint signaling; IBA:GO_Central.
DR GO; GO:0034501; P:protein localization to kinetochore; IEA:Ensembl.
DR GO; GO:0065003; P:protein-containing complex assembly; IEA:Ensembl.
DR GO; GO:0007096; P:regulation of exit from mitosis; IEA:Ensembl.
DR Gene3D; 1.10.357.150; -; 1.
DR InterPro; IPR046362; Zw10/DSL1_C_sf.
DR InterPro; IPR048343; ZW10_C.
DR InterPro; IPR048344; Zw10_middle.
DR InterPro; IPR009361; Zw10_N.
DR PANTHER; PTHR12205; CENTROMERE/KINETOCHORE PROTEIN ZW10; 1.
DR PANTHER; PTHR12205:SF0; CENTROMERE_KINETOCHORE PROTEIN ZW10 HOMOLOG; 1.
DR Pfam; PF20666; ZW10_C; 1.
DR Pfam; PF20665; Zw10_middle; 1.
DR Pfam; PF06248; Zw10_N; 1.
PE 1: Evidence at protein level;
KW Cell cycle {ECO:0000256|ARBA:ARBA00023306};
KW Cell division {ECO:0000256|ARBA:ARBA00022618};
KW Centromere {ECO:0000256|ARBA:ARBA00023328};
KW Chromosome {ECO:0000256|ARBA:ARBA00022454};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Kinetochore {ECO:0000256|ARBA:ARBA00022838};
KW Mitosis {ECO:0000256|ARBA:ARBA00022776};
KW Proteomics identification {ECO:0007829|PeptideAtlas:F1SM67};
KW Reference proteome {ECO:0000313|Proteomes:UP000008227}.
FT DOMAIN 27..119
FT /note="Centromere/kinetochore protein zw10 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF06248"
FT DOMAIN 177..415
FT /note="Centromere/kinetochore protein zw10 middle"
FT /evidence="ECO:0000259|Pfam:PF20665"
FT DOMAIN 472..602
FT /note="Centromere/kinetochore protein zw10 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF20666"
FT COILED 17..83
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 779 AA; 88592 MW; 87EBC73B49C72DDD CRC64;
MASFVTEVLA HSGRLEKEDL CTRISRLTQR VEEIKGEVCS MISKKYSEFL PSMQSAQDLV
TQVDKLSDDI DLLKSRIESE VRRDLHVSTA EFTDLKQQLE RDSVVLSLLK QLQEFSTAIE
EYNCALAEKK YVTAAQRLEE AQKCLKLLKS RKCFDLKILK SLSMELTIQK QNILYHLGEE
WQKLIVWKFP PSKDISNLES CLQTELHLCT EEPQKEEKTP MSPISSVLLA FSLLGELNTK
LKSFGQMLLK YILRPLASCP SLFAVIESQP NIIIIRFESV MTDLEHPSPS EVFAKIRLVL
EVVQKQLLDL PLDADLENEK TSKIILAEML GDMIWEDLSE CLIKNCLVYS IPTNSSKLQQ
YEEIIQSTEE FENALKEMRF LKGNTTDLLK YARNINSHFA NKKCQDVIVA ARNLMTSEIH
NTVKITPASK ISVPDLPSPD EDDKLQVQKV STTQYNEVVN LEPENALDQH SFSLPTCRIS
ESVKKLMELA YQTLVEATTS SDQCAVQLFY SVRNIFHLFH DVVPTYHKEN LQKLPQLAAI
HHNNCMYIAH HLLTLGHQFR LRLAPILCDG TATFVDLVPG FRRLGTECFL AQMRAQKGEL
LERLSSARNF SNMDDEENYS AASKAVRQVL HQLKRLGIVW QDVLPVNVYC KAMGTLLNTA
ISEMIGRITA LEDISTEDGD RLYSLCKTVM DEGPQVFAPL SEESRNRKYQ EEVPVYVPKW
MPFKELMIML QASLQEIGDR WADGKGPLAA AFSSSEVKAL IRALFQNTER RAAALAKIK
//
