ID F1SMI8_PIG Unreviewed; 880 AA.
AC F1SMI8;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 4.
DT 24-JAN-2024, entry version 81.
DE RecName: Full=Complement component C6 {ECO:0000256|ARBA:ARBA00018265};
GN Name=C6 {ECO:0000313|Ensembl:ENSSSCP00000017868.4,
GN ECO:0000313|VGNC:VGNC:86050};
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00000017868.4, ECO:0000313|Proteomes:UP000008227};
RN [1] {ECO:0000313|Ensembl:ENSSSCP00000017868.4, ECO:0000313|Proteomes:UP000008227}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000017868.4,
RC ECO:0000313|Proteomes:UP000008227};
RG Porcine genome sequencing project;
RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSSCP00000017868.4}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
CC -!- FUNCTION: Constituent of the membrane attack complex (MAC) that plays a
CC key role in the innate and adaptive immune response by forming pores in
CC the plasma membrane of target cells. {ECO:0000256|ARBA:ARBA00002409}.
CC -!- SUBUNIT: Component of the membrane attack complex (MAC). MAC assembly
CC is initiated by proteolytic cleavage of C5 into C5a and C5b. C5b binds
CC sequentially C6, C7, C8 and 12-14 copies of the pore-forming subunit
CC C9. {ECO:0000256|ARBA:ARBA00025836}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the complement C6/C7/C8/C9 family.
CC {ECO:0000256|ARBA:ARBA00009214}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00302}.
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DR AlphaFoldDB; F1SMI8; -.
DR PeptideAtlas; F1SMI8; -.
DR Ensembl; ENSSSCT00000018364.5; ENSSSCP00000017868.4; ENSSSCG00000016861.5.
DR VGNC; VGNC:86050; C6.
DR eggNOG; ENOG502QPIM; Eukaryota.
DR GeneTree; ENSGT00940000156814; -.
DR HOGENOM; CLU_014082_0_0_1; -.
DR TreeFam; TF330498; -.
DR ChiTaRS; C6; pig.
DR Proteomes; UP000008227; Chromosome 16.
DR Bgee; ENSSSCG00000016861; Expressed in liver and 21 other cell types or tissues.
DR ExpressionAtlas; F1SMI8; baseline and differential.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005579; C:membrane attack complex; IEA:UniProtKB-KW.
DR GO; GO:0006958; P:complement activation, classical pathway; IEA:UniProtKB-KW.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR GO; GO:0031640; P:killing of cells of another organism; IEA:UniProtKB-KW.
DR CDD; cd00033; CCP; 2.
DR CDD; cd00112; LDLa; 1.
DR Gene3D; 3.30.60.30; -; 2.
DR Gene3D; 2.10.70.10; Complement Module, domain 1; 2.
DR Gene3D; 2.20.100.10; Thrombospondin type-1 (TSP1) repeat; 3.
DR InterPro; IPR048828; C6_KAZAL.
DR InterPro; IPR048831; C8A_B_C6_EGF-like.
DR InterPro; IPR003884; FacI_MAC.
DR InterPro; IPR002350; Kazal_dom.
DR InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR InterPro; IPR001862; MAC_perforin.
DR InterPro; IPR020864; MACPF.
DR InterPro; IPR035976; Sushi/SCR/CCP_sf.
DR InterPro; IPR000436; Sushi_SCR_CCP_dom.
DR InterPro; IPR000884; TSP1_rpt.
DR InterPro; IPR036383; TSP1_rpt_sf.
DR PANTHER; PTHR45742; COMPLEMENT COMPONENT C6; 1.
DR PANTHER; PTHR45742:SF4; COMPLEMENT COMPONENT C6; 1.
DR Pfam; PF21288; C6_KAZAL; 1.
DR Pfam; PF21195; C8A_B_C6_EGF-like; 1.
DR Pfam; PF01823; MACPF; 1.
DR Pfam; PF00084; Sushi; 2.
DR Pfam; PF00090; TSP_1; 2.
DR PRINTS; PR00764; COMPLEMENTC9.
DR SMART; SM00032; CCP; 2.
DR SMART; SM00057; FIMAC; 2.
DR SMART; SM00457; MACPF; 1.
DR SMART; SM00209; TSP1; 3.
DR SUPFAM; SSF57535; Complement control module/SCR domain; 2.
DR SUPFAM; SSF82895; TSP-1 type 1 repeat; 3.
DR PROSITE; PS51465; KAZAL_2; 1.
DR PROSITE; PS51412; MACPF_2; 1.
DR PROSITE; PS50923; SUSHI; 2.
DR PROSITE; PS50092; TSP1; 3.
PE 1: Evidence at protein level;
KW Complement pathway {ECO:0000256|ARBA:ARBA00022875};
KW Cytolysis {ECO:0000256|ARBA:ARBA00022852};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00302}; Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Immunity {ECO:0000256|ARBA:ARBA00022859};
KW Innate immunity {ECO:0000256|ARBA:ARBA00022588};
KW Membrane attack complex {ECO:0000256|ARBA:ARBA00023058};
KW Proteomics identification {ECO:0007829|PeptideAtlas:F1SMI8};
KW Reference proteome {ECO:0000313|Proteomes:UP000008227};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Sushi {ECO:0000256|ARBA:ARBA00022659, ECO:0000256|PROSITE-
KW ProRule:PRU00302}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..880
FT /note="Complement component C6"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5023895665"
FT DOMAIN 161..478
FT /note="MACPF"
FT /evidence="ECO:0000259|PROSITE:PS51412"
FT DOMAIN 587..646
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 647..708
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 730..784
FT /note="Kazal-like"
FT /evidence="ECO:0000259|PROSITE:PS51465"
FT REGION 543..573
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 617..644
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
SQ SEQUENCE 880 AA; 99193 MW; 62808FEE41EF94DC CRC64;
MDIWVVSMFW LFGLIDKSQA CFCDHYPWTQ WSSCSKTCNS GTQTRQRQIT INQYYLDNFC
DRLCTKQETR ECNWQTCPIN CLLGDYGPWS DCDPCVEKQF KVRSILHPNQ FGGQPCTEPL
MTFRPCIPSK LCKIEEVDCK NKFRCDSGRC IASKLECNGE NDSVCSRKYN PIPSVQLMGA
GFHILAGEPR GEVLGNSFTG GICKTVKSSK ASNPFRVPAN LENVQTKEDD FETDFYEDLI
PLENSKDQQA TGFGQEKSSF HVPIFYSSKK SQTSSHNSAF KQAIQASHKK DSSFIRIHKV
IKVLNFTMKT KDLHRIFDDF GTHYFTSGSL GGVYDLLYQF SNEELKNSGL TQEEAKNCIR
IETKKRYFIV TKTKVEHRCT TNRMSEKYEG SFLQGSEKSI SLVKGGRSEY AAALAWEKGS
SGPGEKTYSE WLESVKENPA VIDFEVRLLV RNIPCAVTRR NNLRRAFREY AAKFDPCQCA
PCPNNGRPVL SGTECLCVCQ SGTYGDNCER RAPDYKSNAV DGNWGCWSSW STCDATYKRS
RTRECNNPAP RQGGKPCEGR GGRRNTPCIG DDEDMKEIDL PEIESDSGCP QPVPPENGFI
RNEKTLYSVG EDVEIVCLTG FKTVGYQYFR CLPDRTWRRG DVECQRTDCL LPVVPEVLKL
SPFQRLYKIG DSIELSCPKG FVIAGPSRYT CSGDSWTPPI SSSLTCEQDF LTRLKGHCQP
GQKQLGSECV CLSPEEDCSH HSEDLCVLDT DSNHYFTSSA CKFLAEKCLN NQQLQFLHIG
SCQDGPQLEW GLERIKLSSS STKNESCGYD TCYSWEKCSA TTSKCICLLP FQCLKGGYQH
YCVKMGSSTT TRTMNICEVG AIRCALRKME ILYPGRCRSN
//