ID   F1SMR1_PIG              Unreviewed;       678 AA.
AC   F1SMR1;
DT   03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT   14-DEC-2022, sequence version 4.
DT   27-MAR-2024, entry version 66.
DE   RecName: Full=Tetratricopeptide repeat protein 39B {ECO:0000256|ARBA:ARBA00015483};
GN   Name=TTC39B {ECO:0000313|Ensembl:ENSSSCP00000005575.4,
GN   ECO:0000313|VGNC:VGNC:94552};
OS   Sus scrofa (Pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX   NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00000005575.4, ECO:0000313|Proteomes:UP000008227};
RN   [1] {ECO:0000313|Ensembl:ENSSSCP00000005575.4, ECO:0000313|Proteomes:UP000008227}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000005575.4,
RC   ECO:0000313|Proteomes:UP000008227};
RG   Porcine genome sequencing project;
RL   Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSSSCP00000005575.4}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the TTC39 family.
CC       {ECO:0000256|ARBA:ARBA00006400}.
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DR   AlphaFoldDB; F1SMR1; -.
DR   STRING; 9823.ENSSSCP00000005575; -.
DR   PaxDb; 9823-ENSSSCP00000005575; -.
DR   Ensembl; ENSSSCT00000005717.5; ENSSSCP00000005575.4; ENSSSCG00000005186.5.
DR   VGNC; VGNC:94552; TTC39B.
DR   GeneTree; ENSGT00950000182917; -.
DR   HOGENOM; CLU_010086_3_0_1; -.
DR   InParanoid; F1SMR1; -.
DR   TreeFam; TF313761; -.
DR   Proteomes; UP000008227; Chromosome 1.
DR   Bgee; ENSSSCG00000005186; Expressed in metanephros cortex and 45 other cell types or tissues.
DR   ExpressionAtlas; F1SMR1; baseline and differential.
DR   GO; GO:0042632; P:cholesterol homeostasis; IBA:GO_Central.
DR   GO; GO:0006629; P:lipid metabolic process; IEA:UniProtKB-KW.
DR   GO; GO:0010887; P:negative regulation of cholesterol storage; IBA:GO_Central.
DR   GO; GO:0010874; P:regulation of cholesterol efflux; IBA:GO_Central.
DR   GO; GO:0090181; P:regulation of cholesterol metabolic process; IBA:GO_Central.
DR   Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR   InterPro; IPR019412; Iml2/TPR_39.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   InterPro; IPR019734; TPR_repeat.
DR   PANTHER; PTHR31859; TETRATRICOPEPTIDE REPEAT PROTEIN 39 FAMILY MEMBER; 1.
DR   PANTHER; PTHR31859:SF4; TETRATRICOPEPTIDE REPEAT PROTEIN 39B; 1.
DR   Pfam; PF10300; Iml2-TPR_39; 1.
DR   Pfam; PF13174; TPR_6; 1.
DR   SUPFAM; SSF48452; TPR-like; 1.
PE   3: Inferred from homology;
KW   Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008227};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT   REGION          1..41
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   678 AA;  76821 MW;  E39DF379452771F7 CRC64;
     MDALSVCRRP GQGACWPRPR PGGRTGPPLS SLADAGLRPE PRNRVGSELP VWLLGGGSLR
     RNMALVGNGT ELEADEDIFE DALETLSMAS RIDMATSSQH CSSFDTKQAS GQHRTSAVKR
     SPSTKVDLRS CLEECTVALN LFLSNRFTDA LELLRPWAKD SMYHALGYST IVVMQAVMTF
     EQQDIQNGIS AMKDALQTCQ KYRKKCTVVE SFSSLLSRGS LDQLTEEEMH AEICYAECLL
     QKAALTFVQD ENMINFIKGG LKIRTSYQIY KECLSILHVI QKNKGGQQFL NEFEGGVKLG
     IGAFNLMLSL LPARIIRLLE FIGFSGNREL GIQQLREGAL GKSMRSPLCC LTILAFHTYI
     SLILGTGEVN VVEAESLLEP YLQQFPNGSL MLFYHGRIEL LKGNVEEAQE IFRKCISVQE
     EWKQFHHLCY WELMWIFVFQ QNWMEAYYCS DLLCKESKWS KATYVFLKAA ILSMLPEDDV
     EATKEDVVTL FRQVDGLKQR IAGKSIPTEK FAVRKSRRYS PSLPAPVKLV LPALEMMYVW
     NGFPLVSKRK DLSENLLVTV EKAEAALQSE DSSDYSIDDE CLVKLLKGCC LKNLQRPLQA
     ELCFNHVIQS EKLLKYDHYL VPFTLFELAF LYKNQGEIDK AIKVLETARN NYKDYSLESR
     LHFRIQAALH LWRKSSSD
//