ID F1SMS8_PIG Unreviewed; 518 AA.
AC F1SMS8;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 2.
DT 27-MAR-2024, entry version 80.
DE SubName: Full=Lectin, mannose binding 1 {ECO:0000313|Ensembl:ENSSSCP00000005280.3};
DE SubName: Full=Protein ERGIC-53 {ECO:0000313|EMBL:HDA74410.1};
GN Name=LMAN1 {ECO:0000313|Ensembl:ENSSSCP00000005280.3,
GN ECO:0000313|VGNC:VGNC:89748};
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00000005280.3, ECO:0000313|Proteomes:UP000008227};
RN [1] {ECO:0000313|Ensembl:ENSSSCP00000005280.3, ECO:0000313|Proteomes:UP000008227}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000005280.3,
RC ECO:0000313|Proteomes:UP000008227};
RG Porcine genome sequencing project;
RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:HDA74410.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=30723633; DOI=.7717/peerj.6374;
RA Gilbert D.G.;
RT "Genes of the pig, Sus scrofa, reconstructed with EvidentialGene.";
RL PeerJ 7:E6374-E6374(2019).
RN [3] {ECO:0000313|Ensembl:ENSSSCP00000005280.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; DQIR01118934; HDA74410.1; -; Transcribed_RNA.
DR EMBL; DQIR01199938; HDB55415.1; -; Transcribed_RNA.
DR STRING; 9823.ENSSSCP00000005280; -.
DR PaxDb; 9823-ENSSSCP00000005280; -.
DR Ensembl; ENSSSCT00000005415.5; ENSSSCP00000005280.3; ENSSSCG00000004908.5.
DR VGNC; VGNC:89748; LMAN1.
DR eggNOG; KOG3838; Eukaryota.
DR GeneTree; ENSGT00940000159146; -.
DR HOGENOM; CLU_041093_4_0_1; -.
DR OMA; WSAEFQF; -.
DR OrthoDB; 5355055at2759; -.
DR TreeFam; TF313311; -.
DR Reactome; R-SSC-204005; COPII-mediated vesicle transport.
DR Reactome; R-SSC-5694530; Cargo concentration in the ER.
DR Reactome; R-SSC-8980692; RHOA GTPase cycle.
DR Reactome; R-SSC-9013106; RHOC GTPase cycle.
DR Reactome; R-SSC-9013404; RAC2 GTPase cycle.
DR Reactome; R-SSC-9013405; RHOD GTPase cycle.
DR Reactome; R-SSC-9013408; RHOG GTPase cycle.
DR Reactome; R-SSC-9013423; RAC3 GTPase cycle.
DR Proteomes; UP000008227; Chromosome 1.
DR Bgee; ENSSSCG00000004908; Expressed in epididymis and 44 other cell types or tissues.
DR GO; GO:0030134; C:COPII-coated ER to Golgi transport vesicle; IBA:GO_Central.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IBA:GO_Central.
DR GO; GO:0005793; C:endoplasmic reticulum-Golgi intermediate compartment; IBA:GO_Central.
DR GO; GO:0000139; C:Golgi membrane; IBA:GO_Central.
DR GO; GO:0030017; C:sarcomere; IEA:Ensembl.
DR GO; GO:0005537; F:mannose binding; IBA:GO_Central.
DR GO; GO:0007029; P:endoplasmic reticulum organization; IEA:Ensembl.
DR GO; GO:0006888; P:endoplasmic reticulum to Golgi vesicle-mediated transport; IBA:GO_Central.
DR GO; GO:0007030; P:Golgi organization; IEA:Ensembl.
DR GO; GO:0010638; P:positive regulation of organelle organization; IEA:Ensembl.
DR CDD; cd06902; lectin_ERGIC-53_ERGL; 1.
DR Gene3D; 2.60.120.200; -; 1.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR005052; Lectin_leg.
DR PANTHER; PTHR12223:SF32; PROTEIN ERGIC-53; 1.
DR PANTHER; PTHR12223; VESICULAR MANNOSE-BINDING LECTIN; 1.
DR Pfam; PF03388; Lectin_leg-like; 1.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR PROSITE; PS51328; L_LECTIN_LIKE; 1.
PE 1: Evidence at protein level;
KW Coiled coil {ECO:0000256|SAM:Coils}; Membrane {ECO:0000256|SAM:Phobius};
KW Proteomics identification {ECO:0007829|PeptideAtlas:F1SMS8};
KW Reference proteome {ECO:0000313|Proteomes:UP000008227};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..30
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 31..518
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014571353"
FT TRANSMEM 487..506
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 52..275
FT /note="L-type lectin-like"
FT /evidence="ECO:0000259|PROSITE:PS51328"
FT COILED 287..314
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 518 AA; 58318 MW; ECF0C1F3426CE6AF CRC64;
MARSRQRGLQ TGARPLFCAL LLSLFRFVGG DGVGGDPAAA GSTGSSAAQP HRRFEYKYSF
KGPHLVQSDG TVPFWAYAGN AIPSSDQIRI APSLKSQRGS VWTKAKAAFE NWEVEVTFRV
TGRGRIGADG LAIWYTENQG LEGPVFGSAD MWNGVGIFFD SFDNDGKKNN PAIVIIGNNG
QIQYDHQNDG ANQALASCQR DFRNKPYPIR AKIIYYQKTL TVMIHNGFTP DKNDYEFCAK
VENMIIPAQG HFGISAATGG LADDHDVLSF LTFQLTEPGK EPPTPDKEIS EKEKEKYQEE
FEHFQQELDK KKEEFQKDHP DLQGHPADEI FESIGDRELR QIFEGQNRIH LEIKQLNRQL
DMILDEQRRY VSSLTEEISK RGAGIPGQHG QITQQELDTV VNTQHEILRQ VNEMKNSMSE
TVRLVSGIQH PGSAGGVYET TQHFNDIKEH LHIVKRDIDH LVQRNMPSNE KPKCPELPPF
PSCLSTVHFV IFVVVQTMLF IGYVMYRSQQ EAAAKKFF
//
