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Database: UniProt
Entry: F1SPN9_PIG
LinkDB: F1SPN9_PIG
Original site: F1SPN9_PIG 
ID   F1SPN9_PIG              Unreviewed;       450 AA.
AC   F1SPN9;
DT   03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 3.
DT   08-MAY-2019, entry version 57.
DE   RecName: Full=Hyaluronidase {ECO:0000256|RuleBase:RU610713};
DE            EC=3.2.1.35 {ECO:0000256|RuleBase:RU610713};
DE   AltName: Full=Hyaluronoglucosaminidase {ECO:0000256|RuleBase:RU610713};
GN   Name=HYAL1 {ECO:0000313|Ensembl:ENSSSCP00000012158};
OS   Sus scrofa (Pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Suina; Suidae;
OC   Sus.
OX   NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00000012158, ECO:0000313|Proteomes:UP000008227};
RN   [1] {ECO:0000313|Ensembl:ENSSSCP00000012158, ECO:0000313|Proteomes:UP000008227}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000012158};
RG   Porcine genome sequencing project;
RL   Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSSSCP00000012158}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (MAY-2011) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Random hydrolysis of (1->4)-linkages between N-acetyl-
CC         beta-D-glucosamine and D-glucuronate residues in hyaluronate.;
CC         EC=3.2.1.35; Evidence={ECO:0000256|RuleBase:RU610713};
CC   -!- SIMILARITY: Belongs to the glycosyl hydrolase 56 family.
CC       {ECO:0000256|PIRNR:PIRNR038193, ECO:0000256|RuleBase:RU610713}.
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DR   EMBL; AEMK02000086; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   PRIDE; F1SPN9; -.
DR   Ensembl; ENSSSCT00000012484; ENSSSCP00000012158; ENSSSCG00000011404.
DR   eggNOG; ENOG410IECJ; Eukaryota.
DR   eggNOG; ENOG410XPZT; LUCA.
DR   GeneTree; ENSGT00950000182708; -.
DR   TreeFam; TF321598; -.
DR   Proteomes; UP000008227; Chromosome 13.
DR   Bgee; ENSSSCG00000011404; Expressed in 5 organ(s), highest expression level in heart.
DR   ExpressionAtlas; F1SPN9; baseline and differential.
DR   GO; GO:0031410; C:cytoplasmic vesicle; IEA:Ensembl.
DR   GO; GO:0005615; C:extracellular space; IEA:Ensembl.
DR   GO; GO:0036117; C:hyaluranon cable; IEA:Ensembl.
DR   GO; GO:0005764; C:lysosome; IEA:Ensembl.
DR   GO; GO:0050501; F:hyaluronan synthase activity; IEA:Ensembl.
DR   GO; GO:0004415; F:hyalurononglucosaminidase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0008134; F:transcription factor binding; IEA:Ensembl.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:UniProtKB-UniRule.
DR   GO; GO:0051216; P:cartilage development; IEA:Ensembl.
DR   GO; GO:0044344; P:cellular response to fibroblast growth factor stimulus; IEA:Ensembl.
DR   GO; GO:0071347; P:cellular response to interleukin-1; IEA:Ensembl.
DR   GO; GO:0071467; P:cellular response to pH; IEA:Ensembl.
DR   GO; GO:0036120; P:cellular response to platelet-derived growth factor stimulus; IEA:Ensembl.
DR   GO; GO:0071356; P:cellular response to tumor necrosis factor; IEA:Ensembl.
DR   GO; GO:0071493; P:cellular response to UV-B; IEA:Ensembl.
DR   GO; GO:0060272; P:embryonic skeletal joint morphogenesis; IEA:Ensembl.
DR   GO; GO:0030213; P:hyaluronan biosynthetic process; IEA:Ensembl.
DR   GO; GO:0030214; P:hyaluronan catabolic process; IEA:Ensembl.
DR   GO; GO:0006954; P:inflammatory response; IEA:Ensembl.
DR   GO; GO:0030308; P:negative regulation of cell growth; IEA:Ensembl.
DR   GO; GO:0045766; P:positive regulation of angiogenesis; IEA:Ensembl.
DR   GO; GO:0045785; P:positive regulation of cell adhesion; IEA:Ensembl.
DR   GO; GO:0030307; P:positive regulation of cell growth; IEA:Ensembl.
DR   GO; GO:0010634; P:positive regulation of epithelial cell migration; IEA:Ensembl.
DR   GO; GO:0050679; P:positive regulation of epithelial cell proliferation; IEA:Ensembl.
DR   GO; GO:1900087; P:positive regulation of G1/S transition of mitotic cell cycle; IEA:Ensembl.
DR   GO; GO:1900106; P:positive regulation of hyaluranon cable assembly; IEA:Ensembl.
DR   GO; GO:0046677; P:response to antibiotic; IEA:Ensembl.
DR   GO; GO:0000302; P:response to reactive oxygen species; IEA:Ensembl.
DR   GO; GO:0009615; P:response to virus; IEA:Ensembl.
DR   Gene3D; 3.20.20.70; -; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR017853; Glycoside_hydrolase_SF.
DR   InterPro; IPR018155; Hyaluronidase.
DR   PANTHER; PTHR11769; PTHR11769; 1.
DR   Pfam; PF01630; Glyco_hydro_56; 1.
DR   PIRSF; PIRSF038193; Hyaluronidase; 1.
DR   PRINTS; PR00846; GLHYDRLASE56.
DR   SUPFAM; SSF51445; SSF51445; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000008227};
KW   Disulfide bond {ECO:0000256|PIRSR:PIRSR038193-3};
KW   Glycosidase {ECO:0000256|RuleBase:RU610713};
KW   Hydrolase {ECO:0000256|RuleBase:RU610713};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008227};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     36       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        37    450       Hyaluronidase. {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5011534012.
FT   ACT_SITE    146    146       Proton donor. {ECO:0000256|PIRSR:
FT                                PIRSR038193-1}.
FT   CARBOHYD    365    365       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000256|PIRSR:PIRSR038193-2}.
FT   DISULFID     58    348       {ECO:0000256|PIRSR:PIRSR038193-3}.
FT   DISULFID    222    236       {ECO:0000256|PIRSR:PIRSR038193-3}.
FT   DISULFID    373    384       {ECO:0000256|PIRSR:PIRSR038193-3}.
FT   DISULFID    378    433       {ECO:0000256|PIRSR:PIRSR038193-3}.
FT   DISULFID    435    444       {ECO:0000256|PIRSR:PIRSR038193-3}.
SQ   SEQUENCE   450 AA;  50135 MW;  2731B11A28463CFE CRC64;
     MRPFSPEVSL DLPCAMAAHL LPICTLFLNL LSVAQGSRDP VVPNRPFTTI WNANTQWCLK
     RHGVDVDVSV FEVVVNPGQT FRGPNMTIFY SSQLGTYPYY TSAGEPVFGG LPQNASLDVH
     LNRTFKDILA AMPESNFSGL AVIDWEAWRP RWAFNWDAKD IYRQRSRALV QKQHPDWPAP
     WVEAAAQDQF QEAAQTWMAG TLKLGQTLRP HGLWGFYGFP DCYNYDFQSS NYTGQCPPGV
     SAQNDQLGWL WGQSRALYPS IYLPSALEGT NKTQLYVQHR VNEAFRVAAA AGDPNLPVLP
     YAQIFHDMTN RLLSREELEH SLGESAAQGA AGVVLWVSWE NTRTKESCQS IKEYVDTTLG
     PFILNVTSGA LLCSQAVCSG HGRCVRRPSH TEALPILNPS SFSIKPTPGG GPLTLQGALS
     LKDRVQMAEE FQCRCYPGWR GTWCEQQGTR
//
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