ID   F1SPR2_PIG              Unreviewed;       785 AA.
AC   F1SPR2;
DT   03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT   11-DEC-2019, sequence version 4.
DT   27-MAR-2024, entry version 77.
DE   SubName: Full=Cadherin related family member 4 {ECO:0000313|Ensembl:ENSSSCP00000012144.4};
GN   Name=CDHR4 {ECO:0000313|Ensembl:ENSSSCP00000012144.4,
GN   ECO:0000313|VGNC:VGNC:86491};
OS   Sus scrofa (Pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX   NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00000012144.4, ECO:0000313|Proteomes:UP000008227};
RN   [1] {ECO:0000313|Ensembl:ENSSSCP00000012144.4, ECO:0000313|Proteomes:UP000008227}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000012144.4,
RC   ECO:0000313|Proteomes:UP000008227};
RG   Porcine genome sequencing project;
RL   Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSSSCP00000012144.4}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   AlphaFoldDB; F1SPR2; -.
DR   SMR; F1SPR2; -.
DR   STRING; 9823.ENSSSCP00000012144; -.
DR   PaxDb; 9823-ENSSSCP00000012144; -.
DR   Ensembl; ENSSSCT00000012469.5; ENSSSCP00000012144.4; ENSSSCG00000011391.5.
DR   VGNC; VGNC:86491; CDHR4.
DR   eggNOG; KOG1219; Eukaryota.
DR   GeneTree; ENSGT00940000162824; -.
DR   HOGENOM; CLU_382923_0_0_1; -.
DR   InParanoid; F1SPR2; -.
DR   TreeFam; TF341878; -.
DR   Proteomes; UP000008227; Chromosome 13.
DR   Bgee; ENSSSCG00000011391; Expressed in blood and 24 other cell types or tissues.
DR   GO; GO:0005886; C:plasma membrane; IEA:InterPro.
DR   GO; GO:0005509; F:calcium ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0007155; P:cell adhesion; IBA:GO_Central.
DR   GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR   CDD; cd11304; Cadherin_repeat; 4.
DR   Gene3D; 2.60.40.60; Cadherins; 4.
DR   InterPro; IPR002126; Cadherin-like_dom.
DR   InterPro; IPR015919; Cadherin-like_sf.
DR   InterPro; IPR020894; Cadherin_CS.
DR   PANTHER; PTHR24028; CADHERIN-87A; 1.
DR   PANTHER; PTHR24028:SF123; CADHERIN-RELATED FAMILY MEMBER 4; 1.
DR   Pfam; PF00028; Cadherin; 2.
DR   PRINTS; PR00205; CADHERIN.
DR   SMART; SM00112; CA; 2.
DR   SUPFAM; SSF49313; Cadherin-like; 4.
DR   PROSITE; PS00232; CADHERIN_1; 1.
DR   PROSITE; PS50268; CADHERIN_2; 2.
PE   4: Predicted;
KW   Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PROSITE-
KW   ProRule:PRU00043}; Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008227};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           23..785
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5023815453"
FT   TRANSMEM        684..704
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          336..442
FT                   /note="Cadherin"
FT                   /evidence="ECO:0000259|PROSITE:PS50268"
FT   DOMAIN          441..551
FT                   /note="Cadherin"
FT                   /evidence="ECO:0000259|PROSITE:PS50268"
SQ   SEQUENCE   785 AA;  86158 MW;  544E8218DEFF01A6 CRC64;
     MVLLRSLVLL LALVVSDHHC LPWFINVSES QGPGTILHSF SFNCSYTPTL ELLHVKPPTT
     FFNPPSLTRW QGIYVGKMTL SSMARLDALT VNHYELQLKF TCGKHVMEGP LFVDIQRDPG
     HIQCAGRFAS PAGEIIQVPE TVTPGALLYT LLLPGLEFQG AQMSITSAQD PPYFPGPFSI
     DGQGWLRSPS QGLRGQALKV FQLQILVTFG QGQSCHGMLT VKVLPVASSQ VSFLKQAQNI
     TIPENLIPGS KVVQLQAQGF DVRYEILSPV PCGLFSIGRV DGVVRTTTPL ELAQAPGAGV
     TRLQVKAFEW FQTWASAELD LWVYVHSVNR WPPRCLPALL VTEIPETTPV GTVLNTFTCT
     DPDSPGSTLD YQLLFHSPPG TASLHLQDRA LKVNATLDCD TPGTCFQHAA SILVLDNGQP
     LMTTEVPVLV TVTPVNEFSP ACVPRTFRVR EDAGPYTLLG SVVGTDMDYP HNSIEYYISG
     WSATFAVDRL SGEVRLLGPL DYELQKLYRL TVLLTDHSQD QDPTCNHSGS CTITIEVEDV
     NDHTPECEPP FQELTIHPHP GRSMEVTKVS CRVPQEPQRL AFSYSIVGGN SQSRFSLQGA
     ILVHSDLMLA APWPEQPRTY ELLIRVADAG PSIPHLSTTA TVIVHLVPWR GSTVATITHG
     TTVPSTMTPL LVTDTEAFWQ PEPWFVVVLT VTGTLLLLAL GWLISRLLQG LAQVLQTPSK
     PTQALMLNSI QEPEGSIEGF MEAPRMETPQ ALGSVMSLHF DGRAQDSRTG RDYLFNTHTG
     ARRWL
//