ID F1SQ09_PIG Unreviewed; 341 AA.
AC F1SQ09; A0A4X1SG78;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 03-MAY-2011, sequence version 1.
DT 27-MAR-2024, entry version 85.
DE RecName: Full=Lumican {ECO:0000256|ARBA:ARBA00013370};
GN Name=LUM {ECO:0000313|Ensembl:ENSSSCP00000000978.2,
GN ECO:0000313|VGNC:VGNC:89894};
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00000000978.2, ECO:0000313|Proteomes:UP000008227};
RN [1] {ECO:0000313|Ensembl:ENSSSCP00000000978.2, ECO:0000313|Proteomes:UP000008227}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000000978.2,
RC ECO:0000313|Proteomes:UP000008227};
RG Porcine genome sequencing project;
RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:HCZ83892.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=30723633; DOI=.7717/peerj.6374;
RA Gilbert D.G.;
RT "Genes of the pig, Sus scrofa, reconstructed with EvidentialGene.";
RL PeerJ 7:E6374-E6374(2019).
RN [3] {ECO:0000313|Ensembl:ENSSSCP00000000978.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBUNIT: Binds to laminin. {ECO:0000256|ARBA:ARBA00011719}.
CC -!- SIMILARITY: Belongs to the small leucine-rich proteoglycan (SLRP)
CC family. SLRP class II subfamily. {ECO:0000256|ARBA:ARBA00005818}.
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DR EMBL; DQIR01028417; HCZ83892.1; -; Transcribed_RNA.
DR EMBL; DQIR01215644; HDB71121.1; -; Transcribed_RNA.
DR EMBL; DQIR01231327; HDB86804.1; -; Transcribed_RNA.
DR EMBL; DQIR01248936; HDC04414.1; -; Transcribed_RNA.
DR EMBL; DQIR01267175; HDC22653.1; -; Transcribed_RNA.
DR RefSeq; NP_001230268.1; NM_001243339.1.
DR STRING; 9823.ENSSSCP00000000978; -.
DR PaxDb; 9823-ENSSSCP00000000978; -.
DR Ensembl; ENSSSCT00000001000.5; ENSSSCP00000000978.2; ENSSSCG00000000916.5.
DR Ensembl; ENSSSCT00005028877.1; ENSSSCP00005017629.1; ENSSSCG00005018295.1.
DR Ensembl; ENSSSCT00005028903.1; ENSSSCP00005017635.1; ENSSSCG00005018295.1.
DR GeneID; 100152607; -.
DR KEGG; ssc:100152607; -.
DR CTD; 4060; -.
DR VGNC; VGNC:89894; LUM.
DR eggNOG; KOG0619; Eukaryota.
DR GeneTree; ENSGT00940000158177; -.
DR HOGENOM; CLU_000288_186_4_1; -.
DR OMA; DCPINFP; -.
DR OrthoDB; 521898at2759; -.
DR TreeFam; TF334562; -.
DR Reactome; R-SSC-2022854; Keratan sulfate biosynthesis.
DR Reactome; R-SSC-2022857; Keratan sulfate degradation.
DR Reactome; R-SSC-216083; Integrin cell surface interactions.
DR Proteomes; UP000008227; Chromosome 5.
DR Bgee; ENSSSCG00000000916; Expressed in uterus and 40 other cell types or tissues.
DR Genevisible; F1SQ09; SS.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0005583; C:fibrillar collagen trimer; IEA:Ensembl.
DR GO; GO:0005518; F:collagen binding; IBA:GO_Central.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR GO; GO:0032914; P:positive regulation of transforming growth factor beta1 production; IEA:Ensembl.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 3.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR000372; LRRNT.
DR PANTHER; PTHR45712; AGAP008170-PA; 1.
DR PANTHER; PTHR45712:SF6; LUMICAN; 1.
DR Pfam; PF00560; LRR_1; 1.
DR Pfam; PF13855; LRR_8; 3.
DR Pfam; PF01462; LRRNT; 1.
DR PRINTS; PR00019; LEURICHRPT.
DR SMART; SM00364; LRR_BAC; 4.
DR SMART; SM00365; LRR_SD22; 4.
DR SMART; SM00369; LRR_TYP; 8.
DR SMART; SM00013; LRRNT; 1.
DR SUPFAM; SSF52058; L domain-like; 1.
DR PROSITE; PS51450; LRR; 4.
PE 1: Evidence at protein level;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00022974};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Proteoglycan {ECO:0000256|ARBA:ARBA00022974};
KW Proteomics identification {ECO:0007829|PeptideAtlas:F1SQ09};
KW Reference proteome {ECO:0000313|Proteomes:UP000008227};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP};
KW Sulfation {ECO:0000256|ARBA:ARBA00022641}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..341
FT /note="Lumican"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5041116850"
FT DOMAIN 39..73
FT /note="LRRNT"
FT /evidence="ECO:0000259|SMART:SM00013"
SQ SEQUENCE 341 AA; 38779 MW; 5A2E997E6E4DEE27 CRC64;
MHLGVFTLLL ATIGSASGHY YDDDDYYFPL SIYGRSSPNC APECNCPESY PTAMYCDELK
LKSVPMVPPG IKYLYLRNNQ IDHIDDKAFE NVTDLEWLIL DHNLLENSKI KGRVFSKLKQ
LKKLHINYNN LTESVGPLPK SLVDLQLTNN KISKLGSFDG LVNLTFIHLQ HNQLKEDAVS
AAFRGLKGLE YLDLSFNQMT KLPSGLPVSL LTLYLDNNKI SNIPDEYFKH FSGLQYLRLS
HNELADSGIP GNSFNLSSLL ELDLSYNKLK NIPTVNENLE NYYLEVNELE KFEVKSFCKI
LGPLSYSKIK HLRLDGNRIT QTSLPPDMYE CLRVANEITV N
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