ID F1SUB1_PIG Unreviewed; 104 AA.
AC F1SUB1;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 03-MAY-2011, sequence version 1.
DT 27-MAR-2024, entry version 78.
DE RecName: Full=Pterin-4-alpha-carbinolamine dehydratase {ECO:0000256|ARBA:ARBA00040209};
DE EC=4.2.1.96 {ECO:0000256|ARBA:ARBA00013252};
DE AltName: Full=4-alpha-hydroxy-tetrahydropterin dehydratase {ECO:0000256|ARBA:ARBA00030497};
DE AltName: Full=Dimerization cofactor of hepatocyte nuclear factor 1-alpha {ECO:0000256|ARBA:ARBA00042969};
DE AltName: Full=Phenylalanine hydroxylase-stimulating protein {ECO:0000256|ARBA:ARBA00042558};
DE AltName: Full=Pterin carbinolamine dehydratase {ECO:0000256|ARBA:ARBA00031023};
GN Name=PCBD1 {ECO:0000313|Ensembl:ENSSSCP00000010955.1,
GN ECO:0000313|VGNC:VGNC:91208};
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00000010955.1, ECO:0000313|Proteomes:UP000008227};
RN [1] {ECO:0000313|Ensembl:ENSSSCP00000010955.1, ECO:0000313|Proteomes:UP000008227}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000010955.1,
RC ECO:0000313|Proteomes:UP000008227};
RG Porcine genome sequencing project;
RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSSCP00000010955.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin =
CC (6R)-L-erythro-6,7-dihydrobiopterin + H2O; Xref=Rhea:RHEA:11920,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15642, ChEBI:CHEBI:43120; EC=4.2.1.96;
CC Evidence={ECO:0000256|ARBA:ARBA00001554};
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the pterin-4-alpha-carbinolamine dehydratase
CC family. {ECO:0000256|ARBA:ARBA00006472}.
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DR RefSeq; NP_001177148.1; NM_001190219.1.
DR AlphaFoldDB; F1SUB1; -.
DR SMR; F1SUB1; -.
DR STRING; 9823.ENSSSCP00000010955; -.
DR PaxDb; 9823-ENSSSCP00000010955; -.
DR PeptideAtlas; F1SUB1; -.
DR Ensembl; ENSSSCT00000011247.4; ENSSSCP00000010955.1; ENSSSCG00000010275.4.
DR GeneID; 100155605; -.
DR KEGG; ssc:100155605; -.
DR CTD; 5092; -.
DR VGNC; VGNC:91208; PCBD1.
DR eggNOG; KOG4073; Eukaryota.
DR GeneTree; ENSGT00390000007221; -.
DR HOGENOM; CLU_081974_3_2_1; -.
DR InParanoid; F1SUB1; -.
DR OMA; LPHWTAV; -.
DR OrthoDB; 117067at2759; -.
DR TreeFam; TF300188; -.
DR Reactome; R-SSC-8964208; Phenylalanine metabolism.
DR Proteomes; UP000008227; Chromosome 14.
DR Bgee; ENSSSCG00000010275; Expressed in oocyte and 45 other cell types or tissues.
DR ExpressionAtlas; F1SUB1; baseline and differential.
DR Genevisible; F1SUB1; SS.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0008124; F:4-alpha-hydroxytetrahydrobiopterin dehydratase activity; IBA:GO_Central.
DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR GO; GO:0004505; F:phenylalanine 4-monooxygenase activity; IEA:Ensembl.
DR GO; GO:0006729; P:tetrahydrobiopterin biosynthetic process; IEA:UniProtKB-KW.
DR CDD; cd00914; PCD_DCoH_subfamily_b; 1.
DR Gene3D; 3.30.1360.20; Transcriptional coactivator/pterin dehydratase; 1.
DR HAMAP; MF_00434; Pterin_4_alpha; 1.
DR InterPro; IPR036428; PCD_sf.
DR InterPro; IPR001533; Pterin_deHydtase.
DR PANTHER; PTHR12599; PTERIN-4-ALPHA-CARBINOLAMINE DEHYDRATASE; 1.
DR PANTHER; PTHR12599:SF13; PTERIN-4-ALPHA-CARBINOLAMINE DEHYDRATASE; 1.
DR Pfam; PF01329; Pterin_4a; 1.
DR SUPFAM; SSF55248; PCD-like; 1.
PE 1: Evidence at protein level;
KW Acetylation {ECO:0000256|ARBA:ARBA00022990};
KW Activator {ECO:0000256|ARBA:ARBA00023159};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Lyase {ECO:0000256|ARBA:ARBA00023239};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Proteomics identification {ECO:0007829|PeptideAtlas:F1SUB1};
KW Reference proteome {ECO:0000313|Proteomes:UP000008227};
KW Tetrahydrobiopterin biosynthesis {ECO:0000256|ARBA:ARBA00023007};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
SQ SEQUENCE 104 AA; 12000 MW; 997DF8C2417FE5F5 CRC64;
MAGKAHRLSA EERDQLLPNL RAVGWNELEG RDAIFKQFHF KDFNRAFGFM TRVALQAEKL
DHHPEWFNVY NKVHITLSTH ECAGLSERDI NLASFIEQVA VSMT
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