ID   F1Z290_9STRE            Unreviewed;       173 AA.
AC   F1Z290;
DT   31-MAY-2011, integrated into UniProtKB/TrEMBL.
DT   31-MAY-2011, sequence version 1.
DT   24-JAN-2024, entry version 48.
DE   SubName: Full=3H domain protein {ECO:0000313|EMBL:EGE54209.1};
GN   ORFNames=SPB_0966 {ECO:0000313|EMBL:EGE54209.1};
OS   Streptococcus parauberis NCFD 2020.
OC   Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=873447 {ECO:0000313|EMBL:EGE54209.1, ECO:0000313|Proteomes:UP000003732};
RN   [1] {ECO:0000313|EMBL:EGE54209.1, ECO:0000313|Proteomes:UP000003732}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NCFD 2020 {ECO:0000313|EMBL:EGE54209.1,
RC   ECO:0000313|Proteomes:UP000003732};
RA   Stanhope M.J., Durkin A.S., Hostetler J., Kim M., Radune D., Singh I.,
RA   Town C.D.;
RL   Submitted (FEB-2011) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EGE54209.1}.
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DR   EMBL; AEUT02000001; EGE54209.1; -; Genomic_DNA.
DR   RefSeq; WP_003104515.1; NZ_AEUT02000001.1.
DR   AlphaFoldDB; F1Z290; -.
DR   GeneID; 66816751; -.
DR   eggNOG; COG1827; Bacteria.
DR   HOGENOM; CLU_108798_0_0_9; -.
DR   Proteomes; UP000003732; Unassembled WGS sequence.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0036094; F:small molecule binding; IEA:InterPro.
DR   Gene3D; 3.30.1340.20; 3H domain; 1.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   InterPro; IPR035922; 3H_dom_sf.
DR   InterPro; IPR004173; 3H_domain.
DR   InterPro; IPR013196; HTH_11.
DR   InterPro; IPR026043; NadR.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR40068; TRANSCRIPTION REPRESSOR NIAR-RELATED; 1.
DR   PANTHER; PTHR40068:SF1; TRANSCRIPTION REPRESSOR NIAR-RELATED; 1.
DR   Pfam; PF02829; 3H; 1.
DR   Pfam; PF08279; HTH_11; 1.
DR   PIRSF; PIRSF037847; NiaR; 1.
DR   SUPFAM; SSF75500; Putative transcriptional regulator TM1602, C-terminal domain; 1.
DR   SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
PE   4: Predicted;
KW   Metal-binding {ECO:0000256|PIRSR:PIRSR037847-1};
KW   Nickel {ECO:0000256|PIRSR:PIRSR037847-1}.
FT   DOMAIN          6..59
FT                   /note="Helix-turn-helix type 11"
FT                   /evidence="ECO:0000259|Pfam:PF08279"
FT   DOMAIN          73..169
FT                   /note="3H"
FT                   /evidence="ECO:0000259|Pfam:PF02829"
FT   BINDING         77
FT                   /ligand="Ni(2+)"
FT                   /ligand_id="ChEBI:CHEBI:49786"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR037847-1"
FT   BINDING         85
FT                   /ligand="Ni(2+)"
FT                   /ligand_id="ChEBI:CHEBI:49786"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR037847-1"
FT   BINDING         144
FT                   /ligand="Ni(2+)"
FT                   /ligand_id="ChEBI:CHEBI:49786"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR037847-1"
FT   BINDING         146
FT                   /ligand="Ni(2+)"
FT                   /ligand_id="ChEBI:CHEBI:49786"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR037847-1"
SQ   SEQUENCE   173 AA;  19466 MW;  84A76891C03B6360 CRC64;
     MKAKERRQQI LGMLEKSVTA LSASYLAEEF GVSRQIIVGD IAILRASQVD ILSTPRGYQM
     NQLLTNSNFT GRIVCQHSIE MTEDELDIII SHGGVVSTVE VEHPIYGMLV ASLNIKSKED
     IIDFIYKVNH EQAELLSSLT NGLHSHLISC PSQEQFEMIK KKLAHRNILY INK
//