ID F1Z7K1_9SPHN Unreviewed; 650 AA.
AC F1Z7K1;
DT 31-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 31-MAY-2011, sequence version 1.
DT 27-MAR-2024, entry version 45.
DE SubName: Full=Signal peptide peptidase SppA, 67K type {ECO:0000313|EMBL:EGD59392.1};
GN ORFNames=Y88_1547 {ECO:0000313|EMBL:EGD59392.1};
OS Novosphingobium nitrogenifigens DSM 19370.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Sphingomonadales;
OC Sphingomonadaceae; Novosphingobium.
OX NCBI_TaxID=983920 {ECO:0000313|EMBL:EGD59392.1, ECO:0000313|Proteomes:UP000004728};
RN [1] {ECO:0000313|EMBL:EGD59392.1, ECO:0000313|Proteomes:UP000004728}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 19370 {ECO:0000313|EMBL:EGD59392.1,
RC ECO:0000313|Proteomes:UP000004728};
RX PubMed=22156397; DOI=10.1128/JB.06381-11;
RA Strabala T.J., Macdonald L., Liu V., Smit A.M.;
RT "Draft Genome Sequence of Novosphingobium nitrogenifigens Y88T.";
RL J. Bacteriol. 194:201-201(2012).
CC -!- SIMILARITY: Belongs to the peptidase S49 family.
CC {ECO:0000256|ARBA:ARBA00008683}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EGD59392.1}.
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DR EMBL; AEWJ01000033; EGD59392.1; -; Genomic_DNA.
DR RefSeq; WP_008067715.1; NZ_GL876927.1.
DR AlphaFoldDB; F1Z7K1; -.
DR STRING; 983920.Y88_1547; -.
DR eggNOG; COG0616; Bacteria.
DR HOGENOM; CLU_008856_1_1_5; -.
DR InParanoid; F1Z7K1; -.
DR OrthoDB; 9764363at2; -.
DR Proteomes; UP000004728; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:InterPro.
DR GO; GO:0008236; F:serine-type peptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0006465; P:signal peptide processing; IEA:InterPro.
DR CDD; cd07018; S49_SppA_67K_type; 1.
DR CDD; cd07023; S49_Sppa_N_C; 1.
DR Gene3D; 6.20.330.10; -; 1.
DR InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR InterPro; IPR004634; Pept_S49_pIV.
DR InterPro; IPR002142; Peptidase_S49.
DR InterPro; IPR047217; S49_SppA_67K_type_N.
DR InterPro; IPR047272; S49_SppA_C.
DR NCBIfam; TIGR00705; SppA_67K; 1.
DR PANTHER; PTHR33209; PROTEASE 4; 1.
DR PANTHER; PTHR33209:SF1; SERINE PROTEASE SPPA, CHLOROPLASTIC; 1.
DR Pfam; PF01343; Peptidase_S49; 2.
DR PIRSF; PIRSF001217; Protease_4_SppA; 1.
DR SUPFAM; SSF52096; ClpP/crotonase; 2.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000004728};
KW Serine protease {ECO:0000256|ARBA:ARBA00022825}.
FT DOMAIN 127..278
FT /note="Peptidase S49"
FT /evidence="ECO:0000259|Pfam:PF01343"
FT DOMAIN 377..526
FT /note="Peptidase S49"
FT /evidence="ECO:0000259|Pfam:PF01343"
FT ACT_SITE 193
FT /note="Proton donor/acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR001217-1"
FT ACT_SITE 394
FT /note="Nucleophile"
FT /evidence="ECO:0000256|PIRSR:PIRSR001217-1"
SQ SEQUENCE 650 AA; 67587 MW; 49F3C8A86D847E7A CRC64;
MKFARAVWKI LVAIKDGLVL LLLLLFFGTL SLALSSRPMP GRVKEGALAI TLDGPVVEEK
ARIAPSELLL DGDGAHRQYV AHDLVRAIEA AATDTRIRAV TLDLEGFGGA GQVTLSRLGE
ALDKVRGAGK PVLVRAVLYD DDALQLAAHA SEIWVDPLGG VMVRGPGGTL LFYHGLLDRL
KVKAHVFKVG TYKSAVEPYI RDSLSPEARE AETAVYTAVW HDWLAEVKKA RPRANLALVT
SDPVKWLAAS DGNAAEAAKA AGLVDRIGDK VAFGKRAAEI VGGDRDQGLG GYKATRLGAY
LADLPAQKGG KAIAVVNVEG AIVDGNAGPG VAGGDRIAAL IDRATASGDY AGMVLRVDSP
GGSVTGAERI RAAVERFKAS GLPVAVSMGN LAASGGYWVS TPADRIFAEP ATITGSIGIF
AVIPSFEDSL AKFGVTTDGL RTTPLSGQPS ILGGFSPEME AVLQTEIDAG YHRFVGLVSA
SRHKSYADVD RIAQGRVWDG GTARQIGLVD EFGNLDNALN WVAGKAGATK WHPTYLGEEA
GSLSGMIAQL LSSDDDGSTD SDGSAVYAGG GHDLAARVAT AQFVLAGRMA SDLDVLMGAR
GAQAYCLECA GLERGFAGQA IGGGAGPVST LLGAASGRPE WLLWAARFLR
//
