ID F1ZAH1_9SPHN Unreviewed; 776 AA.
AC F1ZAH1;
DT 31-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 31-MAY-2011, sequence version 1.
DT 24-JAN-2024, entry version 55.
DE SubName: Full=3-hydroxyacyl-CoA dehydrogenase {ECO:0000313|EMBL:EGD58421.1};
GN ORFNames=Y88_0476 {ECO:0000313|EMBL:EGD58421.1};
OS Novosphingobium nitrogenifigens DSM 19370.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Sphingomonadales;
OC Sphingomonadaceae; Novosphingobium.
OX NCBI_TaxID=983920 {ECO:0000313|EMBL:EGD58421.1, ECO:0000313|Proteomes:UP000004728};
RN [1] {ECO:0000313|EMBL:EGD58421.1, ECO:0000313|Proteomes:UP000004728}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 19370 {ECO:0000313|EMBL:EGD58421.1,
RC ECO:0000313|Proteomes:UP000004728};
RX PubMed=22156397; DOI=10.1128/JB.06381-11;
RA Strabala T.J., Macdonald L., Liu V., Smit A.M.;
RT "Draft Genome Sequence of Novosphingobium nitrogenifigens Y88T.";
RL J. Bacteriol. 194:201-201(2012).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + H(+) +
CC NADH; Xref=Rhea:RHEA:22432, ChEBI:CHEBI:15378, ChEBI:CHEBI:57318,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:90726; EC=1.1.1.35;
CC Evidence={ECO:0000256|ARBA:ARBA00023693};
CC -!- PATHWAY: Lipid metabolism; fatty acid beta-oxidation.
CC {ECO:0000256|ARBA:ARBA00005005}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EGD58421.1}.
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DR EMBL; AEWJ01000041; EGD58421.1; -; Genomic_DNA.
DR RefSeq; WP_008066815.1; NZ_GL876926.1.
DR AlphaFoldDB; F1ZAH1; -.
DR STRING; 983920.Y88_0476; -.
DR eggNOG; COG1024; Bacteria.
DR eggNOG; COG1250; Bacteria.
DR HOGENOM; CLU_010448_0_0_5; -.
DR InParanoid; F1ZAH1; -.
DR OrthoDB; 5389341at2; -.
DR UniPathway; UPA00659; -.
DR Proteomes; UP000004728; Unassembled WGS sequence.
DR GO; GO:0003857; F:3-hydroxyacyl-CoA dehydrogenase activity; IEA:UniProtKB-EC.
DR GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR GO; GO:0006635; P:fatty acid beta-oxidation; IEA:UniProtKB-UniPathway.
DR CDD; cd06558; crotonase-like; 1.
DR Gene3D; 1.10.1040.50; -; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR InterPro; IPR006108; 3HC_DH_C.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR InterPro; IPR001753; Enoyl-CoA_hydra/iso.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR48075; 3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN; 1.
DR PANTHER; PTHR48075:SF7; 3-HYDROXYACYL-COA DEHYDROGENASE-RELATED; 1.
DR Pfam; PF00725; 3HCDH; 2.
DR Pfam; PF02737; 3HCDH_N; 1.
DR Pfam; PF00378; ECH_1; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 2.
DR SUPFAM; SSF52096; ClpP/crotonase; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 4: Predicted;
KW Fatty acid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW Lipid degradation {ECO:0000256|ARBA:ARBA00022963};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW Reference proteome {ECO:0000313|Proteomes:UP000004728}.
FT DOMAIN 11..194
FT /note="3-hydroxyacyl-CoA dehydrogenase NAD binding"
FT /evidence="ECO:0000259|Pfam:PF02737"
FT DOMAIN 196..297
FT /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00725"
FT DOMAIN 350..394
FT /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00725"
SQ SEQUENCE 776 AA; 81486 MW; 127509897DDE75BE CRC64;
MSSIATEPVR KVCVIGAGVM GAGIAAQVAN AGVPVLLLDI VRDPADRNAV AAGALKRLQK
AEPAAFMSKR AAKLVEVGNI EDDLARVAEC DWVIEAIIER LDLKHALYEK LEAVRRPGTA
VTSNTSTIPL GHLVAGRSEG FARDFFITHF FNPPRYMRLL EVVAGPASDA ALVARISDFA
DRALGKTIVA CKDTPGFLAN RVGTFWLQSA VNAAFDLGLT VEEADAIAGK PMGVPKTGIF
GLVDLVGIDL MPHLKASLTS TLPADDPYHA IAIDHPLITR MIGEGLTGRK GKGGFYRINR
EAGKRREAID LASGEYRPQA KPASLPSAAQ KDLKALLALP GKAGAYAWAI LGATLTYAAS
LLPQAADDVV AIDAAMKLGY NWKYGPFELI DRIGGADFVA RLEADGKAVP EVLRIAAGRP
FYRIEAGKRQ YLGLDGAYHD LVRPDGVLLL EDIKLGAKPI IRNASAALWD IGDGVAALEF
TSKMNAIDGE ILKLIGQAVP LVASKFKALV VYNEGSAFSA GANLGLALFA INIAAWGEIE
KMVSGGQMAL KALKYAPFPV VAAPAGLALG GGCEIVLHAD AVQAHAESYI GLVECGVGLV
PGWGGCGEML ARWQAAKGLP KGPVPAVSKV FETISTATVS KSAAEAMDLG FLRPTDGITM
NRDRLLADAK ARALALAEGY QPPAPPTYRL PGAGGKAALE LAVAGFRARG MATPHDAVVA
GHLADVLTGG EADLVDTVAE GDLLALERKA FLALVRHPGT QNRIEHMLKT GKPLRN
//
