ID F2BYE9_9FIRM Unreviewed; 167 AA.
AC F2BYE9;
DT 31-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 31-MAY-2011, sequence version 1.
DT 24-JAN-2024, entry version 55.
DE RecName: Full=Transcriptional repressor NrdR {ECO:0000256|HAMAP-Rule:MF_00440};
GN Name=iro {ECO:0000313|EMBL:EGF12470.1};
GN Synonyms=nrdR {ECO:0000256|HAMAP-Rule:MF_00440};
GN ORFNames=HMPREF9083_1217 {ECO:0000313|EMBL:EGF12470.1};
OS Dialister micraerophilus DSM 19965.
OC Bacteria; Bacillota; Negativicutes; Veillonellales; Veillonellaceae;
OC Dialister.
OX NCBI_TaxID=888062 {ECO:0000313|EMBL:EGF12470.1, ECO:0000313|Proteomes:UP000003503};
RN [1] {ECO:0000313|EMBL:EGF12470.1, ECO:0000313|Proteomes:UP000003503}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 19965 {ECO:0000313|EMBL:EGF12470.1,
RC ECO:0000313|Proteomes:UP000003503};
RA Muzny D., Qin X., Deng J., Jiang H., Liu Y., Qu J., Song X.-Z., Zhang L.,
RA Thornton R., Coyle M., Francisco L., Jackson L., Javaid M., Korchina V.,
RA Kovar C., Mata R., Mathew T., Ngo R., Nguyen L., Nguyen N., Okwuonu G.,
RA Ongeri F., Pham C., Simmons D., Wilczek-Boney K., Hale W., Jakkamsetti A.,
RA Pham P., Ruth R., San Lucas F., Warren J., Zhang J., Zhao Z., Zhou C.,
RA Zhu D., Lee S., Bess C., Blankenburg K., Forbes L., Fu Q., Gubbala S.,
RA Hirani K., Jayaseelan J.C., Lara F., Munidasa M., Palculict T., Patil S.,
RA Pu L.-L., Saada N., Tang L., Weissenberger G., Zhu Y., Hemphill L.,
RA Shang Y., Youmans B., Ayvaz T., Ross M., Santibanez J., Aqrawi P.,
RA Gross S., Joshi V., Fowler G., Nazareth L., Reid J., Worley K.,
RA Petrosino J., Highlander S., Gibbs R.;
RL Submitted (FEB-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Negatively regulates transcription of bacterial
CC ribonucleotide reductase nrd genes and operons by binding to NrdR-
CC boxes. {ECO:0000256|HAMAP-Rule:MF_00440}.
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|HAMAP-Rule:MF_00440};
CC Note=Binds 1 zinc ion. {ECO:0000256|HAMAP-Rule:MF_00440};
CC -!- SIMILARITY: Belongs to the NrdR family. {ECO:0000256|HAMAP-
CC Rule:MF_00440}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EGF12470.1}.
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DR EMBL; AFBB01000025; EGF12470.1; -; Genomic_DNA.
DR RefSeq; WP_007556493.1; NZ_GL878519.1.
DR AlphaFoldDB; F2BYE9; -.
DR STRING; 888062.HMPREF9083_1217; -.
DR eggNOG; COG1327; Bacteria.
DR HOGENOM; CLU_108412_0_0_9; -.
DR Proteomes; UP000003503; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0045892; P:negative regulation of DNA-templated transcription; IEA:UniProtKB-UniRule.
DR HAMAP; MF_00440; NrdR; 1.
DR InterPro; IPR005144; ATP-cone_dom.
DR InterPro; IPR003796; RNR_NrdR-like.
DR NCBIfam; TIGR00244; transcriptional regulator NrdR; 1.
DR PANTHER; PTHR30455; TRANSCRIPTIONAL REPRESSOR NRDR; 1.
DR PANTHER; PTHR30455:SF2; TRANSCRIPTIONAL REPRESSOR NRDR; 1.
DR Pfam; PF03477; ATP-cone; 1.
DR PROSITE; PS51161; ATP_CONE; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW Rule:MF_00440};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW Rule:MF_00440}; Metal-binding {ECO:0000256|HAMAP-Rule:MF_00440};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW Rule:MF_00440}; Oxidoreductase {ECO:0000313|EMBL:EGF12470.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000003503};
KW Repressor {ECO:0000256|ARBA:ARBA00022491, ECO:0000256|HAMAP-Rule:MF_00440};
KW Transcription {ECO:0000256|ARBA:ARBA00023163, ECO:0000256|HAMAP-
KW Rule:MF_00440};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015, ECO:0000256|HAMAP-
KW Rule:MF_00440};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|HAMAP-Rule:MF_00440};
KW Zinc-finger {ECO:0000256|HAMAP-Rule:MF_00440}.
FT DOMAIN 49..139
FT /note="ATP-cone"
FT /evidence="ECO:0000259|PROSITE:PS51161"
FT ZN_FING 3..34
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00440"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 167 AA; 19881 MW; 6BD1F47E424C5022 CRC64;
MKCPFCKNKD TKVTDSRDTD DGTSIRRRRQ CLTCKKRFTT YESIESTPVR VIKKDGTREL
FDKNKIRNGL IRACEKRNIS TEQIEQVVEK IEIKVYNALK QEIYTETIGN WIMEELKELD
QVSYVRFASV YREFKDLESF MSELRMLMRK ESNENGLDKE VKENKKL
//
