ID F2CUW0_HORVV Unreviewed; 225 AA.
AC F2CUW0;
DT 31-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 31-MAY-2011, sequence version 1.
DT 27-MAR-2024, entry version 72.
DE RecName: Full=Calcineurin B-like protein {ECO:0000256|RuleBase:RU369080};
OS Hordeum vulgare subsp. vulgare (Domesticated barley).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Pooideae; Triticodae; Triticeae; Hordeinae; Hordeum.
OX NCBI_TaxID=112509 {ECO:0000313|EMBL:BAJ86631.1};
RN [1] {ECO:0000313|EMBL:BAJ86631.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Leaf {ECO:0000313|EMBL:BAJ86631.1};
RX PubMed=21415278; DOI=10.1104/pp.110.171579;
RA Matsumoto T., Tanaka T., Sakai H., Amano N., Kanamori H., Kurita K.,
RA Kikuta A., Kamiya K., Yamamoto M., Ikawa H., Fujii N., Hori K., Itoh T.,
RA Sato K.;
RT "Comprehensive sequence analysis of 24,783 barley full-length cDNAs derived
RT from 12 clone libraries.";
RL Plant Physiol. 156:20-28(2011).
RN [2] {ECO:0000313|Proteomes:UP000011116}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Morex {ECO:0000313|Proteomes:UP000011116};
RX PubMed=23075845; DOI=10.1038/nature11543;
RG The International Barley Genome Sequencing Consortium;
RA Mayer K.F., Waugh R., Brown J.W., Schulman A., Langridge P., Platzer M.,
RA Fincher G.B., Muehlbauer G.J., Sato K., Close T.J., Wise R.P., Stein N.;
RT "A physical, genetic and functional sequence assembly of the barley
RT genome.";
RL Nature 491:711-716(2012).
RN [3] {ECO:0000313|EnsemblPlants:HORVU.MOREX.r3.5HG0436600.1}
RP IDENTIFICATION.
RC STRAIN=subsp. vulgare
RC {ECO:0000313|EnsemblPlants:HORVU.MOREX.r3.5HG0436600.1};
RG EnsemblPlants;
RL Submitted (JAN-2022) to UniProtKB.
CC -!- FUNCTION: Acts as a calcium sensor. CBL proteins interact with CIPK
CC serine-threonine protein kinases. Binding of a CBL protein to the
CC regulatory NAF domain of a CIPK protein lead to the activation of the
CC kinase in a calcium-dependent manner. {ECO:0000256|RuleBase:RU369080}.
CC -!- SUBUNIT: Homodimer. Interacts with CIPK.
CC {ECO:0000256|RuleBase:RU369080}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU369080}.
CC -!- SIMILARITY: Belongs to the calcineurin regulatory subunit family.
CC {ECO:0000256|ARBA:ARBA00023774, ECO:0000256|RuleBase:RU369080}.
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DR EMBL; AK355412; BAJ86631.1; -; mRNA.
DR AlphaFoldDB; F2CUW0; -.
DR SMR; F2CUW0; -.
DR STRING; 112509.F2CUW0; -.
DR PaxDb; 4513-MLOC_16711-1; -.
DR EnsemblPlants; HORVU.MOREX.r3.5HG0436600.1; HORVU.MOREX.r3.5HG0436600.1; HORVU.MOREX.r3.5HG0436600.
DR Gramene; HORVU.MOREX.r2.5HG0361320.1; HORVU.MOREX.r2.5HG0361320.1; HORVU.MOREX.r2.5HG0361320.
DR Gramene; HORVU.MOREX.r2.5HG0361320.1.mrna1; HORVU.MOREX.r2.5HG0361320.1.mrna1; HORVU.MOREX.r2.5HG0361320.1.
DR Gramene; HORVU.MOREX.r3.5HG0436600.1; HORVU.MOREX.r3.5HG0436600.1; HORVU.MOREX.r3.5HG0436600.
DR eggNOG; KOG0034; Eukaryota.
DR HOGENOM; CLU_061288_21_0_1; -.
DR OMA; GAVMKMP; -.
DR OrthoDB; 90710at2759; -.
DR Proteomes; UP000011116; Chromosome 5H.
DR ExpressionAtlas; F2CUW0; baseline and differential.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0019900; F:kinase binding; IEA:UniProtKB-UniRule.
DR GO; GO:0019722; P:calcium-mediated signaling; IEA:UniProtKB-UniRule.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR InterPro; IPR045198; CNBL1-10.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR002048; EF_hand_dom.
DR PANTHER; PTHR23056; CALCINEURIN B; 1.
DR PANTHER; PTHR23056:SF116; CALCINEURIN B-LIKE PROTEIN 2; 1.
DR Pfam; PF13499; EF-hand_7; 1.
DR Pfam; PF13833; EF-hand_8; 1.
DR PRINTS; PR00450; RECOVERIN.
DR SMART; SM00054; EFh; 3.
DR SUPFAM; SSF47473; EF-hand; 1.
DR PROSITE; PS50222; EF_HAND_2; 3.
PE 2: Evidence at transcript level;
KW Calcium {ECO:0000256|RuleBase:RU369080};
KW Membrane {ECO:0000256|RuleBase:RU369080};
KW Metal-binding {ECO:0000256|RuleBase:RU369080};
KW Reference proteome {ECO:0000313|Proteomes:UP000011116};
KW Repeat {ECO:0000256|ARBA:ARBA00022737, ECO:0000256|RuleBase:RU369080}.
FT DOMAIN 81..116
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT DOMAIN 118..153
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT DOMAIN 162..197
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
SQ SEQUENCE 225 AA; 25883 MW; F51DFEB94B29A827 CRC64;
MVQCLDGVKH LLAVLFKCCD LELKQPRGLE DPQVLARETV FSVSEVEALY ELFKKISSAV
IDDGLINKEE FQLALFKTSK KESLFADRVF DLFDTKHNGI LGFEEFARAL SVFHPNASVE
EKIDFSFQLY DLKQQGFIER QEVKQMVVAT LAESGMNLSD EIIENIIDKT FEEADTKHDG
KIDREEWHNL VLRHPSLLKN MTLQYLKDIT TTFPSFVFHS QVDDT
//
